Is Diabetes Mellitus a Prognostic Factor for Survival in Patients with Small Cell Lung Cancer?

İnal, Ali; Kaplan, Muhammet Ali; Küçüköner, Mehmet; Urakçı, Zuhat; Karakuş, Abdullah; Nas, Necip; Güven, Mehmet; Işıkdoğan, Abdurrahman

doi:10.7314/apjcp.2012.13.4.1491

Cited by 7 publications

(5 citation statements)

References 28 publications

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“… 20 However, a retrospective study in Turkey reviewed 161 SCLC patients with a focus on diabetes and other prognostic variables reported that diabetes at the time of diagnosis of SCLC did not have prognostic importance for survival. 21 This results was disconcordant to our study, probably due to the relatively small sample size compared to ours. Physicians should increase awareness to recognize the associated comorbidities, including cardiovascular disease and diabetes, when providing patient care because the coexistence of comorbidities requires the integration of multiple disciplines and awareness of drug‐drug interactions during cancer treatment.…”

Section: Discussioncontrasting

confidence: 52%

Impact of Chronic Obstructive Pulmonary Disease on the Mortality of Patients with Small Cell Lung Cancer

Liao

Hung

Lee

et al. 2021

COPD

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Background Limited studies have focused on the impact of the coexistence of small cell lung cancer (SCLC) and chronic obstructive pulmonary disease (COPD). The study was to examine the impact of COPD on mortality in SCLC patients. Methods We analyzed SCLC patients from the Taiwan Cancer Registry Database between January 1, 1997, and December 31, 2015. The COPD population was composed of patients with a COPD diagnosis before the diagnosis of SCLC. The control group was composed of randomly selected SCLC patients without COPD who were propensity score matched with those with concomitant COPD according to age, sex, index date, cancer staging and comorbidities at a 1:1 ratio. Results Among 9425 SCLC patients in the database, eligible subjects were divided into the COPD group (n = 4235) and the non-COPD group (n = 2334). Compared to patients in the non-COPD group, the patients in the COPD group were older (71.4 versus 65.7 years, p<0.0001), had a lower percentage of stage IV disease (60.1% versus 68.3%, p<0.0001) and had more comorbidities. After matching, there were 1457 patients in each group. Older age, lower body mass index (BMI), and some comorbidities were associated with higher mortality, and comorbid COPD was associated with lower 1-year mortality in SCLC patients. Multivariate analysis identified older age, lower BMI, and concomitant congestive heart failure or diabetes as risk factors for OS. Conclusion A diagnosis of COPD was associated with reduced 1-year mortality in SCLC patients, but no significant difference after 1-year in this population.

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Section: Discussioncontrasting

confidence: 52%

Impact of Chronic Obstructive Pulmonary Disease on the Mortality of Patients with Small Cell Lung Cancer

Liao

Hung

Lee

et al. 2021

COPD

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“…Also, STAT3 plays a crucial role in chemotherapy [40]. The findings of a previous study suggested that DM at the time of diagnosis had no association with survival in patients with SCLC [41], although small cell lung cancer (SCLC) patients generally only survive for a short time anyway, and hence survival may not be affected by the presence of DM. In contrast, DM was found to be a negative prognostic factor for the treatment of advanced NSCLC [22], although at least half the patients in that study had stage IV disease, and thus also had a poor prognosis.…”

Section: Discussionmentioning

confidence: 87%

Prognostic Significance of Diabetes Mellitus in Locally Advanced Non-small Cell Lung Cancer

Imai¹

2017

kmj

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“…The findings of a previous study suggested that DM at the time of diagnosis had no association with survival in patients with SCLC [ 41 ], although small cell lung cancer (SCLC) patients generally only survive for a short time anyway, and hence survival may not be affected by the presence of DM. In contrast, DM was found to be a negative prognostic factor for the treatment of advanced NSCLC [ 22 ], although at least half the patients in that study had stage IV disease, and thus also had a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of diabetes mellitus in locally advanced non-small cell lung cancer

et al. 2015

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BackgroundTo investigate the prognostic significance of patient characteristics and clinical laboratory test results in locally advanced non-small cell lung cancer (NSCLC), and in particular the impact of diabetes mellitus (DM) on the survival of patients who underwent chemoradiotherapy.MethodsWe retrospectively reviewed 159 patients with locally advanced NSCLC with a focus on DM and other potential prognostic factors, using the log-rank test, and univariate and multivariate analyses to assess their association with survival.ResultFive significant prognostic factors were identified in univariate analysis: stage (p < 0.001), DM (p = 0.04), hemoglobin levels (p = 0.003), serum albumin (p <0.001) and lactate dehydrogenase (LDH) levels (p = 0.01). Furthermore, among the factors tested using Fisher's exact test and the Wilcoxon rank sum test, gender (p = 0.019) and plasma glucose level (p <0.001) were found to have prognostic significance. Multivariate analysis showed that stage, DM, serum albumin and LDH levels were independent prognostic factors for survival (p = 0.007, p = 0.024, p = 0.007 and p = 0.005, respectively).ConclusionsThe presence of DM at the time of diagnosis was identified as an independent and significant prognostic factor for predicting negative outcome in locally advanced NSCLC patients.

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Is Diabetes Mellitus a Prognostic Factor for Survival in Patients with Small Cell Lung Cancer?

Cited by 7 publications

References 28 publications

Impact of Chronic Obstructive Pulmonary Disease on the Mortality of Patients with Small Cell Lung Cancer

Impact of Chronic Obstructive Pulmonary Disease on the Mortality of Patients with Small Cell Lung Cancer

Prognostic Significance of Diabetes Mellitus in Locally Advanced Non-small Cell Lung Cancer

Prognostic significance of diabetes mellitus in locally advanced non-small cell lung cancer

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