Is elevated Red cell distribution width a prognostic predictor in adult patients with community acquired Pneumonia?

Braun, Eyal; Kheir, Jad; Mashiach, Tanya; Naffaa, Mohammad E.; Azzam, Zaher S.

doi:10.1186/1471-2334-14-129

Cited by 53 publications

(44 citation statements)

References 25 publications

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“…The adjusted OR rose from1.12 to 1.40. RDW was reported as a binary variable in 2 studies [28, 33], and we found that the increased RDW levels were associated with a higher risk of death (OR, 2.12; 95%CI, 1.82–2.46) with low heterogeneity ( I 2 = 0, P = 0.49). And 4 studies provided data on AUC from 0.63 to 0.76 of RDW in prediction mortality [23, 25, 31, 33].…”

Section: Resultsmentioning

confidence: 85%

“…In addition, because of the studies by Purtle et al and Bazick et al were conducted in the same hospitals and derived from the same study periods [2, 12] and the risk of data duplication was inevitable, thus the study by Purtle et al was excluded [12]. A similar situation also occurred in the studies by Braun et al [26, 28], and his early study was excluded [26]. There was no additional studies were obtained through reviewing the bibliographies of relevant reviews or systematic reviews and there was no discrepancy between two reviewers.…”

Section: Resultsmentioning

confidence: 99%

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Prognostic Value of Red Blood Cell Distribution Width in Non-Cardiovascular Critically or Acutely Patients: A Systematic Review

Luo

Jiang

et al. 2016

PLoS ONE

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BackgroundRDW (red cell distribution width) has been reported to been associated with the prognosis of patients with cardiovascular diseases. However, RDW is often overlooked by clinicians in treating patients with non-cardiovascular diseases, especially in an emergency. The objective of this systematic review is to explore the prognostic value of RDW in non-cardiovascular emergencies.MethodsPubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were systematically searched from their inception to December 31, 2015. We included studies examining the relationship between RDW and mortality rate by adjusting important covariables in non-cardiovascular emergencies. All included studies were divided into three groups. Group A: general critically ill patients; Group B: patients with infectious disease; Group C: other conditions. We extracted each study’ characteristics, outcomes, covariables, and other items independently.ResultsA total of 32 studies were eligible for inclusion in our meta-analysis. Six studies belonged to Group A, 9 studies belonged to Group B and 17 studies belonged to Group C. Among these included studies, RDW was assessed as a continuous variable (per 1% increase) in 16 studies, as a binary variable in 8 studies, and as a categorical variable in 8 studies. In addition, AUCs (area under the receiver operating characteristic curve) of RDW for predicting mortality were reported in 25 studies. All studies were published between 2011–2015. The qualities of included 32 studies were moderate or high.ConclusionThe present systematic review indicates that the increased RDW is significantly associated with a higher mortality rate in an non-cardiovascular emergency. The low cost and readily accessible of this laboratory variable may strengthen its usefulness in daily practice in the future.

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Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Prognostic Value of Red Blood Cell Distribution Width in Non-Cardiovascular Critically or Acutely Patients: A Systematic Review

Luo

Jiang

et al. 2016

PLoS ONE

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“…(8) In one study done by Eyal Braun et al in 2014, where 3815 patients of community acquired pneumonia were studied, they found 16.9% (32.69% in our study) mortality in patients with RDW <=15% and 21.7% (59.18% in our study) mortality in patients with RDW >15%. (9) In another study done by Nader A Mahmood et al in 2014 RDW ≥16% was independently associated with an APACHE II score of ≥15. This suggests that septic patients with an RDW ≥16% may have a higher severity of illness.…”

Section: Discussionmentioning

confidence: 92%

Role of Red Blood Cell Distribution Width as a Prognostic Marker in Patients With Severe Sepsis and Septic Shock

Punekar¹,

Jain²,

Yawalkar³

et al. 2016

jemds

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BACKGROUNDRed Cell Distribution Width (RDW) is widely available to clinicians, because it is routinely reported as part of complete blood count. Several studies have reported that RDW is closely related to outcome in critically ill patients. Severe sepsis and septic shock are increasing in incidence and contributing significantly to mortality. Prediction of outcome for patients with sepsis using easily available and reliable marker may facilitate more aggressive interventions made at appropriate time. We studied this correlation and whether changes in Red cell distribution width reflects acute changes in disease progression.

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“…Specifically, it is associated with high rate of morbidity and mortality in the case of patients with chronic heart failure [22, 23, 24]. Likewise, it is a marker of poor prognosis for patients with infectious diseases [25, 26]. However, there are relatively few reports focusing on RDW in the area of oncology.…”

Section: Discussionmentioning

confidence: 99%

Assessment of red blood cell distribution width as a prognostic marker in chronic lymphocytic leukemia

et al. 2016

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Red blood cell distribution width (RDW) is a quantitative measure of the variability in size of circulating erythrocytes. It was recently reported that RDW is a prognostic factor for infection diseases, cardiovascular and pulmonary diseases, as well as some neoplasms. Moreover, RDW is remarkably strong predictor of longevity, including all causes of death, for adults aged 45 years and older. To explain this occurrence it was proposed that persistent IGFs/mTOR signaling is one of the factors that play a role in affecting the RDW and mortality.The above observations induced us to analyze the prognostic role of RDW in chronic lymphocytic leukemia (CLL) being the most frequent type of adult leukemia in Western countries. The obtained results have shown that RDW may be considered as a potential CLL prognostic marker. Elevated RDW level at the moment of diagnosis was associated with advanced disease and presence of other poor prognostic factors. It is also connected with overall survival indicating shorter time in patients with elevated RDW. It is possible that the presently observed correlation between mortality and RDW of the CLL patients is affected by their metabolic (IGF-1/mTOR driven)- rather than chronological- aging. The patients with high level of RDW are expected to have an increased persistent level of IGF-1/mTOR signaling. Within the framework of personalized therapy, these CLL patients therefore would be expected to be more sensitive to the treatment with mTOR inhibitors.

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Is elevated Red cell distribution width a prognostic predictor in adult patients with community acquired Pneumonia?

Cited by 53 publications

References 25 publications

Prognostic Value of Red Blood Cell Distribution Width in Non-Cardiovascular Critically or Acutely Patients: A Systematic Review

Prognostic Value of Red Blood Cell Distribution Width in Non-Cardiovascular Critically or Acutely Patients: A Systematic Review

Role of Red Blood Cell Distribution Width as a Prognostic Marker in Patients With Severe Sepsis and Septic Shock

Assessment of red blood cell distribution width as a prognostic marker in chronic lymphocytic leukemia

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