Is gamma band EEG synchronization reduced during auditory driving in schizophrenia patients with auditory verbal hallucinations?

Koenig, Thomas; Swam, Claudia van; Dierks, Thomas; Hubl, Daniela

doi:10.1016/j.schres.2012.07.016

Cited by 30 publications

(30 citation statements)

References 39 publications

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“…Reductions in PV have previously been reported in the MAM model in both the mPFC and ventral subiculum (Lodge et al, 2009). Importantly, these reductions were associated with alterations in task-induced gamma oscillations during the latent inhibition paradigm, similar to what has been reported in schizophrenia patients (Spencer et al, 2003; Symond et al, 2005; Bucci et al, 2007; Williams et al, 2009; Koenig et al, 2012). Consequently, PV is the most suitable target when assessing immunohistochemical changes in the MAM model.…”

Section: Discussionsupporting

confidence: 83%

Corresponding decrease in neuronal markers signals progressive parvalbumin neuron loss in MAM schizophrenia model

Gill

Grace

2014

Int. J. Neuropsychopharm.

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Alteration in normal hippocampal (HPC) function attributed to reduced parvalbumin (PV) expression has been consistently reported in schizophrenia patients and in animal models of schizophrenia. However, it is unclear whether there is an overall loss of interneurons as opposed to a reduction in activity-dependent PV content. Co-expression of PV and the constitutively-expressed substance P (SP)-receptor protein has been utilized in other models to ascertain the degree of cell survival, as opposed to reduction in activity-dependent PV content, in the HPC. The present study measured the co-expression of PV and SP-receptors in the dentate and dorsal and ventral CA3 subregions of the HPC in the methylazoymethanol acetate (MAM) rat neurodevelopmental model of schizophrenia. In addition, these changes were compared at the postnatal day 27 (PND27) and post-natal day 240 (PND240) time points. Brains from PND27 and PND240 MAM (n=8) and saline (SAL, n=8) treated offspring were immunohistochemically processed for the co-expression of PV and SP-receptors. The dorsal dentate, dorsal CA3 and ventral CA3 subregions of PND27 and PND>240 MAM rats demonstrated significant reductions in PV but not SP-receptor expression, signifying a loss of PV-content. In contrast, in the ventral dentate the co-expression of PV and SP-receptors was significantly reduced only in PND>240 MAM animals, suggesting a reduction in cell number. While MAM-induced reduction of PV content occurs in CA3 of dorsal and ventral HPC, the most substantial loss of interneuron number is localized to the ventral dentate of PND>240 animals. The disparate loss of PV in HPC subregions likely impacts intra-HPC network activity in MAM rats.

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Section: Discussionsupporting

confidence: 83%

Corresponding decrease in neuronal markers signals progressive parvalbumin neuron loss in MAM schizophrenia model

Gill

Grace

2014

Int. J. Neuropsychopharm.

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“…Using simultaneous EEG-fMRI, class D microstates have been suggested to be related to a right-lateralized frontoparietal network associated with attention reorientation (Britz et al, 2010). Koenig et al used measure of phase synchrony and demonstrated a left-lateralized phase synchrony −decrease in patients with AVH during 40 Hz auditory stimulation, in contrast to a phase synchrony −increase in healthy subjects or patients without AVH (Koenig et al, 2012, Griskova-Bulanova et al, 2016). …”

Section: Eeg-based Connectivity Analysesmentioning

confidence: 99%

Interaction of language, auditory and memory brain networks in auditory verbal hallucinations

Ćurčić‐Blake

Ford

Hubl

et al. 2017

Progress in Neurobiology

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181

155

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HighlightsThe language, auditory and memory/limbic networks are of particular relevance for auditory verbal hallucinations.An increased interaction among the auditory-language and striatal brain regions occurs while patients hallucinate.Fronto-temporal connections are often altered in AVH individuals, but there is no consensus regarding increase or decrease.Connections of the interhemispheric auditory pathway are stronger for first episode patients, but they are weaker in chronic patients.The majority of studies support hybrid AVH hypotheses in which all three networks and the striatal network are involved.

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“…Moreover, postmortem studies have shown that schizophrenia patients exhibit a substantial reduction of PV in GABAergic interneurons of the hippocampus (Benes et al, 2007; Konradi et al, 2011), but also of the PFC (Beasley et al, 2002; Kalus et al, 2002; Lewis et al, 2001). This PV loss is thought to disrupt inhibitory networks and contribute to the hyperactivity and loss of evoked gamma rhythms within the PFC and the hippocampus (Koenig et al, 2012; Lisman et al, 2008; Spencer et al, 2003; Volk and Lewis, 2010). Deficits in prefrontal cortical function likely contribute to cognitive impairments and working memory deficits (Gonzalez-Burgos et al, 2015), whereas aberrant hippocampal function is associated with positive symptom severity (Schobel et al, 2009).…”

Section: Dopamine System Dysregulation In a Neurodevelopmental Modmentioning

confidence: 99%

Adolescence as a period of vulnerability and intervention in schizophrenia: Insights from the MAM model

Gomes¹,

Rincón-Cortés²,

Grace³

2016

Neuroscience & Biobehavioral Reviews

108

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Adolescence is a time of extensive neuroanatomical, functional and chemical reorganization of the brain, which parallels substantial maturational changes in behavior and cognition. Environmental factors that impinge on the timing of these developmental factors, including stress and drug exposure, increase the risk for psychiatric disorders. Indeed, antecedents to affective and psychotic disorders, which have clinical and pathophysiological overlap, are commonly associated with risk factors during adolescence that predispose to these disorders. In the context of schizophrenia, psychosis typically begins in late adolescence/early adulthood, which has been replicated by animal models. Rats exposed during gestational day (GD) 17 to the mitotoxin methylazoxymethanol acetate (MAM) exhibit behavioral, pharmacological, and anatomical characteristics consistent with an animal model of schizophrenia. Here we provide an overview of adolescent changes within the dopamine system and the PFC and review recent findings regarding the effects of stress and cannabis exposure during the peripubertal period as risk factors for the emergence of schizophrenia-like deficits. Finally, we discuss peripubertal interventions appearing to circumvent the emergence of adult schizophrenia-like deficits.

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Is gamma band EEG synchronization reduced during auditory driving in schizophrenia patients with auditory verbal hallucinations?

Cited by 30 publications

References 39 publications

Corresponding decrease in neuronal markers signals progressive parvalbumin neuron loss in MAM schizophrenia model

Corresponding decrease in neuronal markers signals progressive parvalbumin neuron loss in MAM schizophrenia model

Interaction of language, auditory and memory brain networks in auditory verbal hallucinations

Adolescence as a period of vulnerability and intervention in schizophrenia: Insights from the MAM model

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