Is grand multiparity a risk factor for the development of postmenopausal osteoporosis?

Peker, Nuri; Tosun, Özge Çeliker

doi:10.2147/cia.s155793

Cited by 14 publications

(8 citation statements)

References 12 publications

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“…Demir and colleagues also showed that postmenopausal osteoporosis is associated with duration of menopause rather than age at menopause [32], and bone loss is accelerated mainly due to rapid estrogen deprivation. In parallel with some studies [33,34], we could not detect significant relation between multiparity and osteoporosis. At the same time, Peker et al showed a significant association between femoral osteoporosis and multiparity but not in lumbar osteoporosis [33].…”

Section: Discussionsupporting

confidence: 83%

“…In parallel with some studies [33,34], we could not detect significant relation between multiparity and osteoporosis. At the same time, Peker et al showed a significant association between femoral osteoporosis and multiparity but not in lumbar osteoporosis [33]. Some other studies revealed a negative effect of multiparity on bone density [32,35].…”

Section: Discussionsupporting

confidence: 83%

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Prevalence of osteoporosis among the elderly population of Iran

et al. 2021

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In a large population-based study of Iran, the age-standardized prevalence of osteoporosis was 24.6% in men and 62.7% in women aged ≥ 60 years. Osteoporosis was negatively associated with body mass index in both sexes, and with diabetes in men and hypertriglyceridemia in women.Purpose Population aging has made osteoporosis and osteoporotic fractures an important health problem, especially in developing countries. This study aimed to explore the prevalence of osteoporosis and associated factors among the elderly population of the south-west of Iran. Methods Baseline data of the second stage of the Bushehr Elderly Health program was used. Spinal, total hip, or femoral neck osteoporosis was described as a BMD that lies 2.5 standard deviations or more, below the average values of a young healthy adult in the lumbar spine, total hip, or femoral neck, respectively. Osteoporosis at either site was defined as total osteoporosis. Agestandardized prevalence of osteoporosis was estimated. We used the modified Poisson regression with a robust variance estimator to identify the factors related to osteoporosis, adjusting for potential confounders. Results Overall, 2425 individuals (1166 men) aged over 60 years were included. In all, total osteoporosis was detected in 1006 (41.5%) of the participants. Using the reference value derived from Caucasian women aged 20-29 years, the age-standardized prevalence of total osteoporosis was 24.6 (95% CI: 21.9-27.3) in men, and 62.7 (95% CI: 60.0-65.4) in women. In men, osteoporosis was positively associated with age, smoking, history of fracture, and history of renal/liver diseases and negatively associated with body mass index (BMI) and diabetes. BMI, hypertriglyceridemia, and education were negatively correlated with osteoporosis in women, while years after menopause and history of fracture increased the likelihood of osteoporosis, significantly. Conclusion Results support the high prevalence of osteoporosis and osteopenia in the elderly population. Considering the importance of severe complications, especially fractures, comprehensive interventions should be expanded.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 83%

Prevalence of osteoporosis among the elderly population of Iran

et al. 2021

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“…However, a similar tendency of younger women having better screening practice than older women in Karachi was previously observed in a study carried out in 2018, which concluded that the most frequent age of diagnosis for breast cancer was in the 40s [24]. No significant association was detected between multiple pregnancies and better DEXA practice either, even though the frequency of osteoporosis in a study was found to be significantly higher in women with five to nine pregnancies compared with women having <5 pregnancies [25]. However, the link between parity and BMD and duration of breastfeeding and BMD remains largely unclear, as some reports have shown that bone loss associated with these factors is recovered after weaning [26].…”

Section: Discussionsupporting

confidence: 58%

Dual Energy X-ray Absorptiometry Scanning and Bone Health: The Pressing Need to Raise Awareness Amongst Pakistani Women

Anwar

Iftekhar

Taher

et al. 2019

Cureus

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The use of dual-energy x-ray absorptiometry (DEXA) scanning is instrumental in better management of osteoporosis. This study aimed to assess the level of knowledge about DEXA scanning and bone health in the women of Karachi, as well as to analyze their practices concerning the scan and increase their knowledge and awareness regarding the same. Methodology The sample size for this cross-sectional study was 384. Data were collected using a self-devised and validated questionnaire, consisting of four sections: social demographics, general knowledge about DEXA scanning, practices regarding DEXA, and knowledge about bone health. The data were analyzed using Statistical Package for the Social Sciences (SPSS) version 23 and associations between multiple variables calculated, using independent sample t-test and Pearson's chi-squared test. Results Only one-third of our sample population had heard about DEXA scanning and amongst them, nobody had complete knowledge about it. The mean score of general knowledge of DEXA (5.3±2.0) was higher than that of knowledge about the conditions in which DEXA scanning is recommended (2.7±2.1). The knowledge score showed a significant correlation with education (p=0.007) and employment (p=0.001). Only 7.6% of the sample population had taken a DEXA scan and knowledge and employment status were found to have significant associations with practices (p value=0.000 and 0.001, respectively). Conclusions The awareness levels regarding DEXA scans and bone health should be evaluated amongst similar and other groups of people and effective measures be put into application to educate the public and to guide them towards better prevention and management of osteoporosis.

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“…In a hospital-based cross sectional study from India, parity was negatively correlated with the BMD of neck of the femur, trochanter, lumbar spine, and forearm [6]. In a study from Turkey, low BMD was associated with high parity in postmenopausal women [7]. Similar research demonstrated that low BMD of the spine and hip in postmenopausal women with parity greater than six [8].…”

Section: Discussionmentioning

confidence: 78%

The inverse association between parity and bone health is independent of lifestyle in postmenopausal Chinese women

Yang

et al. 2020

Endocr J

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This study aimed to investigate the association between parity and bone mineral density in postmenopausal Chinese women, as well as the interference of physical activity and sedentary time on this association. A total of 1,712 participants were enrolled in this study. Participants were separated into three groups according to the number of parities: group 1, 1-2; group 2, 3-4; group 3, ≥5. Physical activity level was assessed according to the International Physical Activity Questionnaire. Calcaneus bone mineral density (BMD) and bone quality were assessed by qualitative ultrasound. As a result, logistic regression showed that compared to that in group 1, the risk of fracture in group 3 was increased significantly (p < 0.001). A greater number of parities was associated with a lower BMD, broadband ultrasonic attenuation (BUA), quantitative ultrasound index (QUI), speed of sound (SOS), and T-score among the three groups after adjustment for age (All p for trend < 0.05). The number of parities was an independent factor negatively correlated with BMD, BUA, QUI, SOS and T-score (All p < 0.05). BMD, BUA, QUI, SOS, and T-score were significantly increased in the physically a participants independent of parity (all p < 0.05), and decreased in the sedentary participants independent of parity (p < 0.05, except BUA). A great number of parities was negatively associated with bone health. Physical activity was positively correlated and sedentary time was negatively correlated with bone health independent of parity.

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Is grand multiparity a risk factor for the development of postmenopausal osteoporosis?

Cited by 14 publications

References 12 publications

Prevalence of osteoporosis among the elderly population of Iran

Prevalence of osteoporosis among the elderly population of Iran

Dual Energy X-ray Absorptiometry Scanning and Bone Health: The Pressing Need to Raise Awareness Amongst Pakistani Women

The inverse association between parity and bone health is independent of lifestyle in postmenopausal Chinese women

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