Is Helicobacter pylori eradication associated with gastroesophageal reflux disease?

Influence of cure of Helicobacter pylori infection on gastric acidity and gastroesophageal reflux: study by 24-h pH monitoring in patients with gastric or duodenal ulcer

“…Since the time of Labenz's report, the onset of RE after H. pylori eradication has attracted attention and many additional studies were conducted in this regard. Despite the support for the assumption presented by Labenz et al, 1 given by some researchers, 9,15 many other reports up to the present have given a negative view of that assumption, and, at present, the negative view is predominant. Laine and Sugg 6 aggregated and analyzed the results of eight double-blind prospective studies, and reported that the incidence of RE after H. pylori eradication was 4% (24/ 621 patients) in the eradication-success group and 3% (14/544 patients) in the eradication-failure group, indicating no difference in the incidence of RE between the groups.…”

Development of reflux esophagitis following Helicobacter pylori eradication

“…According to their report, when duodenal ulcer patients with no associated reflux esophagitis underwent H. pylori eradication therapy and were followed for a mean period of 3 years, reflux esophagitis developed in 25.8% of the H. pylori-cured patients and in 12.9% of patients without H. pylori eradication therapy or unsuccessful H. pylori eradication therapy. Many related reports have since been published, with some 12,13 reporting an increase of reflux esophagitis after H. pylori eradication and others 14,15 refuting such an increase. Thus, there is a state of confusion, including the question of the incidence of reflux esophagitis.…”

Patients with Helicobacter pylori infection have less severe gastroesophageal reflux disease: a study using endoscopy, 24-hour gastric and esophageal pH metry

“…Several studies suggest a possible protective role of H. pylori in GERD [10][11][12][13][14][15][16]. Furthermore, eradication of H. pylori may result both in de novo occurrence and exacerbation of GERD [17].…”