Patients with Helicobacter pylori infection have less severe gastroesophageal reflux disease: a study using endoscopy, 24-hour gastric and esophageal pH metry

Chourasia, Dipti; Misra, Asha; Tripathi, Shweta; Krishnani, Narendra; Ghoshal, Uday C

doi:10.1007/s12664-010-0078-0

Cited by 20 publications

(19 citation statements)

References 48 publications

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“…H. pylori seropositivity has been known to protect against gastroesophageal reflux in Asia, especially in the Far East 11-13. Furthermore, patients with H. pylori infection have less severe gastroesophageal reflux disease,14,15 however, H. pylori infection does not always influence gastroesophageal reflux disease, and the effect of eradication of H. pylori on reflux esophagitis is controversial 16-20. Given the regional differences in seroprevalence of H. pylori in Korea,21 multicenter, prospective studies on the risk factors of reflux esophagitis seem to be important.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Erosive Esophagitis Is Not Significantly Increased in a Healthy Korean Population - Could It Be Explained?: A Multi-center Prospective Study

Seo

Jeon

Chung

et al. 2013

J Neurogastroenterol Motil

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Background/AimsResearches on the potential risk factors for the development of erosive esophagitis have been conducted extensively, however, the results are conflicting. The aim of this multicenter study was to identify the prevalence rate and risk factors of erosive esophagitis and their interactions with residency status.MethodsA total of 4,023 eligible subjects at 8 tertiary health care centers were evaluated using questionnaires, laboratory tests and endoscopy. Univariate and multivariate analyses were conducted to identify independent risk factors for erosive esophagitis.ResultsThe prevalence rate of reflux esophagitis was 8.8%. Los Angeles grade A was common type of erosive esophagitis. Residence in a large urban areas was negatively associated with the development of erosive esophagitis (OR, 0.60; 95% CI, 0.40-0.90). The high body mass index (≥ 25 kg/m2) was more frequent in residents of small and medium-sized cities than those in big cities (38.8% and 26.9%, respectively; P < 0.001). Seronegativity of Helicobacter pylori was associated with increased erosive esophagitis (OR, 1.91; 95% CI, 1.48-2.46). Triglyceride ≥ 150 mg/dL (OR, 1.65; 95% CI, 1.08-2.07), fasting glucose level ≥ 126 mg/dL (OR, 1.73; 95% CI, 1.06-2.81), and hiatal hernia (OR, 3.11; 95% CI, 1.87-5.16) were also associated with erosive esophagitis.ConclusionsThe prevalence rate of erosive esophagitis and its risk factors in this study were similar to the result of 8.0% of nationwide study in 2006. Residency and obesity are more important independent risk factors than H. pylori infection status for development of erosive esophagitis in Korea. These results suggest that the prevalence rate of erosive esophagitis in Korea might not increase as in the Western countries.

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Section: Introductionmentioning

confidence: 99%

The Prevalence of Erosive Esophagitis Is Not Significantly Increased in a Healthy Korean Population - Could It Be Explained?: A Multi-center Prospective Study

Seo

Jeon

Chung

et al. 2013

J Neurogastroenterol Motil

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“…On the other hand, studies in a multiethnic population showed that people of Indian origin are at higher risk of GERD than ethnic Malay and Chinese [6]. The high prevalence of H. pylori infection, which is known to protect from severe GERD and its complications, might be one of the explanations for the lower frequency of complications of GERD in the Indian population [9,10]. The role of dietary and genetic factors is not clear.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and symptom profile of gastroesophageal reflux in the Indian population: Report of the Indian Society of Gastroenterology Task Force

Bhatia¹,

Reddy²,

Ghoshal³

et al. 2011

Indian J Gastroenterol

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“…Therefore, we can only make some speculations on the underlying conditions affecting different symptom patterns. First, the more severe degrees of esophagitis seem to be less correlated to H. pylori presence [19] ; this could be one explanation for a major heartburn in our patients without infection. However, we can only partially confirm this assumption because in order to properly reduce the chance of confounding bias in our analysis, we excluded patients with Los Angeles grade C-D, known to have fewer reflux symptoms [20] .…”

Section: Discussionmentioning

confidence: 74%

Typical and atypical symptoms of gastro esophageal reflux disease: DoesHelicobacter pyloriinfection matter?

Grossi

Ciccaglione

Marzio

2015

WJGPT

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AIM:To analyze whether the presence of Helicobacter pylori (H. pylori ) infection could affect the quality of symptoms in gastro-esophageal reflux disease (GERD) patients.METHODS: one hundred and forty-four consecutive patients referred to our Unit for suspected GERD were recruited for the study. All patients underwent esophageal pH-metric recording. For those with a positive test, C13 urea breath test was then performed to assess the H. pylori status. GERD patients were stratified according to the quality of their symptoms and classified as typical, if affected by heartburn and regurgitation, and atypical if complaining of chest pain, respiratory and ears, nose, and throat features. H. pylori -negative patients were also asked whether they had a previous diagnosis of H. pylori infection. If a positive response was given, on the basis of the time period after successful eradication, patients were considered as "eradicated" (E) if H. pylori eradication occurred more than six months earlier or "recently eradicated" if the therapy had been administered within the last six months. Patients without history of infection were identified as "negative" (N CONCLUSION: Atypical symptoms of GERD occur more frequently in H. pylori -positive patients than in H. pylori -negative subjects. In addition, atypical symptoms tend to decrease after H. pylori eradication.

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Patients with Helicobacter pylori infection have less severe gastroesophageal reflux disease: a study using endoscopy, 24-hour gastric and esophageal pH metry

Abstract: H. pylori infection is associated with less acidic stomach and less severe GERD. Low gastrin-17, higher age, hiatus hernia and absence of H. pylori were the best predictors for EE risk.

Cited by 20 publications

References 48 publications

The Prevalence of Erosive Esophagitis Is Not Significantly Increased in a Healthy Korean Population - Could It Be Explained?: A Multi-center Prospective Study

The Prevalence of Erosive Esophagitis Is Not Significantly Increased in a Healthy Korean Population - Could It Be Explained?: A Multi-center Prospective Study

Epidemiology and symptom profile of gastroesophageal reflux in the Indian population: Report of the Indian Society of Gastroenterology Task Force

Typical and atypical symptoms of gastro esophageal reflux disease: DoesHelicobacter pyloriinfection matter?

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