Is Hepatitis B Virus a Player in Pancreatic Cancer?

Dumitraşcu, Traian; Pineau, Pascal

doi:10.21614/chirurgia.113.3.344

Cited by 4 publications

(1 citation statement)

References 64 publications

(118 reference statements)

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“…The transport of the virus from hepatic parenchyma to the pancreatic anatomical region is mainly attributed to the commonly shared ductal and vasculature system, with HBV being transferred to pancreatic parenchyma, which leads to a chronic inflammatory state that promotes pancreatic carcinogenesis. Another hypothesis is the common embryonic origin of hepatocytes and pancreatic cells, as well as the molecular background of HBV infection, which induces various genetic and epigenetic aberrations [ 60 , 62 , 63 ]. Unfortunately, there are no studies focusing on HBV-associated PAC and the immune microenvironment.…”

Section: Hepatitis B Virus (Hbv)mentioning

confidence: 99%

Immune Microenvironment and Immunotherapeutic Management in Virus-Associated Digestive System Tumors

Sarantis

Trifylli

Koustas

et al. 2022

IJMS

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The development of cancer is a multifactorial phenomenon, while it constitutes a major global health problem. Viruses are an important factor that is involved in tumorigenesis and is associated with 12.1% of all cancer cases. Major examples of oncogenic viruses which are closely associated with the digestive system are HBV, HCV, EBV, HPV, JCV, and CMV. EBV, HPV, JCV, and CMV directly cause oncogenesis by expressing oncogenic proteins that are encoded in their genome. In contrast, HBV and HCV are correlated indirectly with carcinogenesis by causing chronic inflammation in the infected organs. In addition, the tumor microenvironment contains various immune cells, endothelial cells, and fibroblasts, as well as several growth factors, cytokines, and other tumor-secreted molecules that play a key role in tumor growth, progression, and migration, while they are closely interrelated with the virus. The presence of T-regulatory and B-regulatory cells in the tumor microenvironment plays an important role in the anti-tumor immune reaction. The tumor immune microenvironments differ in each type of cancer and depend on viral infection. The alterations in the immune microenvironment caused by viruses are also reflected in the effectiveness of immunotherapy. The present review aims at shedding light on the association between viruses and digestive system malignancies, the characteristics of the tumor immune microenvironment that develop, and the possible treatments that can be administered.

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Section: Hepatitis B Virus (Hbv)mentioning

confidence: 99%

Immune Microenvironment and Immunotherapeutic Management in Virus-Associated Digestive System Tumors

Sarantis

Trifylli

Koustas

et al. 2022

IJMS

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Research Progress of Tumor Microenvironment in the Pathogenesis of Pancreatic Cancer

段¹

2022

ACM

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HBV Infection Status Does Not Influence the Initial Metastatic Pattern and the Prognosis of Breast Cancer Patients with de novo and Relapsed Metastatic Disease

Tao¹,

Lei²,

Shao³

et al. 2022

JIR

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Purpose This study aimed to evaluate the influence of hepatitis B virus (HBV) infection status on the initial metastatic pattern and prognosis in metastatic breast cancer (MBC). Methods MBC patients admitted to Chongqing University Cancer Hospital between January 2011 and December 2019 were enrolled. The association of HBV infection status with clinicopathological features was analyzed. The impact of HBV infection status on initial metastatic pattern and survival was evaluated. Results A total of 1124 patients with MBC, including 310 with de novo (cohort A) and 814 with relapsed metastatic disease (cohort B), were eligible for this study. Seropositive HBsAg was identified in 28 (9.0%) and 68 (8.4%) patients in cohort A and B, respectively. The clinicopathological features are similar between HBsAg-positive and HBsAg-negative patients. There was no significant association of HBV infection status with the rate of metastasis at each site in de novo and relapsed MBC. HBsAg-positive patients tended to have longer metastasis-free survival (MFS) and/or overall survival (OS) time, but it was not the independent prognostic factor. Conclusion In conclusion, HBV infection status does not influence the initial metastatic pattern and the prognosis of MBC patients.

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Is Hepatitis B Virus a Player in Pancreatic Cancer?

Cited by 4 publications

References 64 publications

Immune Microenvironment and Immunotherapeutic Management in Virus-Associated Digestive System Tumors

Immune Microenvironment and Immunotherapeutic Management in Virus-Associated Digestive System Tumors

Research Progress of Tumor Microenvironment in the Pathogenesis of Pancreatic Cancer

HBV Infection Status Does Not Influence the Initial Metastatic Pattern and the Prognosis of Breast Cancer Patients with de novo and Relapsed Metastatic Disease

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