Is Hepatitis C Virus Infection a Trigger of Porphyria Cutanea Tarda?

Herrero, Carmen; Vicente, A.; Bruguera, Miquel; Ercilla, M. G.; Barrera, J.M.; Vidal, J.; Terés, Josep; Mascaró, José M.; Rodés, Juan

doi:10.1007/978-4-431-68255-4_56

Cited by 43 publications

(67 citation statements)

References 3 publications

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“…68 As PCT may be the first indication of an HCV infection, it is important to be searched in all patients. 69 The hypotheses explaining the role of HCV in PCT encompass: (1) lower Urod activity secondary to hepatocyte injury; 64,70 (2) changes in the cytochrome P450 oxidase-dependent system; 70 and (3) increased auto-immune response in the liver.31 Auto-antibodies would occur due to a mechanism of molecular mimicking 71 and they act as inhibitors of the Urod catalytic activity. 72 There is also slight increase in the prevalence of hepatitis B.…”

Section: Triggerrring Factorsmentioning

confidence: 99%

Porfiria cutânea tardia

Vieira

Martins

2006

An. Bras. Dermatol.

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Section: Triggerrring Factorsmentioning

confidence: 99%

Porfiria cutânea tardia

Vieira

Martins

2006

An. Bras. Dermatol.

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“…Alcohol and metabolic disorder of iron were previously speculated to be involved in the etiology of PCT. In recent years, however, manystudies suggesting the relationship between HCVand PCT(more than 50%) have been reported especially in Southern Europe (10)(11)(12). In Japan, it was reported that approximately 70% of PCT patients were complicated by HCV infection ( 1 3).…”

Section: Gianotti Diseasementioning

confidence: 99%

Hepatitis Virus and Extrahepatic Manifestations. Skin, Mucosa, Muscle, and Hematopoietic Organs.

Sata

Nagao

2001

Intern. Med.

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“…In addition, patients present with chronic liver disease, moderate iron overload; in some countries, patients present with a high association with hepatotropic virus infections. High prevalence of hepatitis C virus (HCV) markers were recently reported in Southern European patients (76%-95%), [3][4][5][6][7][8][9] and patients from the United States (50%-75%). [10][11] In contrast, lower prevalence has been reported in Northern Europe (8%-18%) [12][13][14] and New Zealand (0%).…”

Section: Porphyria Cutanea Tarda (Pct) Is Caused By a Decreased Activmentioning

confidence: 99%

Hepatic uroporphyrinogen decarboxylase activity in porphyria cutanea tarda patients: The influence of virus C infection

et al. 1998

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Porphyria cutanea tarda (PCT) is caused by a decreased activity of the hepatic enzyme uroporphyrinogen decarboxylase (URO-D). This deficiency causes overproduction, hepatic deposition, and increased excretion of uroporphyrin. Iron overload and hepatic viral infections are considered aggravating factors of the disease. Two forms of PCT have been described, as follows: a familial one with an inherited decrease of URO-D activity in all tissues and a sporadic one with a decreased activity of URO-D restricted to the liver. To assess whether the hepatic URO-D returns to normal during a remission of the disease, this activity was measured in liver biopsy samples in 24 sporadic PCT patients. The hepatic and urinary porphyrin concentrations were also measured. Viral status and histopathological findings were analyzed to assess their involvement in PCT. Six patients treated by phlebotomy to reduce hepatic iron and who were considered to be in clinical remission, characterized by a disappearance of cutaneous lesions, showed higher hepatic URO-D activities and lower hepatic porphyrin concentrations than did patients with overt PCT. The medians of these variables, however, did not achieve normal values. The hepatic URO-D activity showed a significant inverse relationship with both hepatic porphyrins and urinary uroporphyrin excretion. Hepatic URO-D activity was not reduced by hepatitis C virus (HCV) infection and liver damage. We conclude that the achievement of remission in PCT largely depends on the transient normalization of hepatic URO-D activity. A small increase in hepatic coproporphyrin in nonporphyric patients could reflect hepatic injury/iron/alcohol-induced oxidative stress oxidizing the accumulated heme precursors rather than a direct effect on hepatic URO-D enzyme. (HEPATOLOGY 1998; 27:584-589.)

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Is Hepatitis C Virus Infection a Trigger of Porphyria Cutanea Tarda?

Cited by 43 publications

References 3 publications

Porfiria cutânea tardia

Porfiria cutânea tardia

Hepatitis Virus and Extrahepatic Manifestations. Skin, Mucosa, Muscle, and Hematopoietic Organs.

Hepatic uroporphyrinogen decarboxylase activity in porphyria cutanea tarda patients: The influence of virus C infection

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