Is Human Papilloma Virus Infection Linked to Periodontitis? A Narrative Review

Ortiz, Ana P.; Ramos-Cartagena, Jeslie M.; García-Camacho, Sandra I.; Andriankaja, Oelisoa M.; Pérez, Cynthia M.

doi:10.1007/s40496-019-0206-6

Cited by 9 publications

(24 citation statements)

References 42 publications

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“…The loss of cellular adhesion, in addition to the continuous deepening of the periodontal pocket, results in successive exposure of basal epithelial cell layers. As basal cells are the exclusive cellular targets for human papillomavirus (HPV) in the oral cavity, these exposed basal cells provide access points to HPV infections [ 168 ]. Further proliferation of these cells favors the persistence of the HPV infection by sustaining viral replication, thus making the infected periodontal pockets reservoirs of this virus [ 168 ].…”

Section: Changes In the Periodontal Microenvironment That Contribute To The Pathogenesis Of Osccmentioning

confidence: 99%

“…As basal cells are the exclusive cellular targets for human papillomavirus (HPV) in the oral cavity, these exposed basal cells provide access points to HPV infections [ 168 ]. Further proliferation of these cells favors the persistence of the HPV infection by sustaining viral replication, thus making the infected periodontal pockets reservoirs of this virus [ 168 ]. As a central risk factor for cancer development, around 70% of oropharyngeal cancers have been linked to HPV infections [ 169 ].…”

Section: Changes In the Periodontal Microenvironment That Contribute To The Pathogenesis Of Osccmentioning

confidence: 99%

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The Crossroads of Periodontitis and Oral Squamous Cell Carcinoma: Immune Implications and Tumor Promoting Capacities

Elebyary

Barbour

Fine

et al. 2021

Front. Oral. Health

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Periodontitis (PD) is increasingly considered to interact with and promote a number of inflammatory diseases, including cancer. In the case of oral squamous cell carcinoma (OSCC) the local inflammatory response associated with PD is capable of triggering altered cellular events that can promote cancer cell invasion and proliferation of existing primary oral carcinomas as well as supporting the seeding of metastatic tumor cells into the gingival tissue giving rise to secondary tumors. Both the immune and stromal components of the periodontium exhibit phenotypic alterations and functional differences during PD that result in a microenvironment that favors cancer progression. The inflammatory milieu in PD is ideal for cancer cell seeding, migration, proliferation and immune escape. Understanding the interactions governing this attenuated anti-tumor immune response is vital to unveil unexplored preventive or therapeutic possibilities. Here we review the many commonalities between the oral-inflammatory microenvironment in PD and oral-inflammatory responses that are associated with OSCC progression, and how these conditions can act to promote and sustain the hallmarks of cancer.

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Section: Changes In the Periodontal Microenvironment That Contribute To The Pathogenesis Of Osccmentioning

confidence: 99%

Section: Changes In the Periodontal Microenvironment That Contribute To The Pathogenesis Of Osccmentioning

confidence: 99%

The Crossroads of Periodontitis and Oral Squamous Cell Carcinoma: Immune Implications and Tumor Promoting Capacities

Elebyary

Barbour

Fine

et al. 2021

Front. Oral. Health

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“…A recent review article highlights the contradictory evidence regarding the association between periodontitis and oral HPV infection. These potentially conflictive findings are attributed to the diversity of methodologies to determine periodontitis and oral HPV infection and the consideration of periodontitis severity (Ortiz et al, 2019). The biological plausibility for this association includes the possibility of periodontal tissue as a potential reservoir for oral HPV infection and facilitation of HPV persistence by chronic inflammation of the tissue (Ortiz et al, 2019; Syrjänen, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…These potentially conflictive findings are attributed to the diversity of methodologies to determine periodontitis and oral HPV infection and the consideration of periodontitis severity (Ortiz et al, 2019). The biological plausibility for this association includes the possibility of periodontal tissue as a potential reservoir for oral HPV infection and facilitation of HPV persistence by chronic inflammation of the tissue (Ortiz et al, 2019; Syrjänen, 2018). A recent meta‐analysis evaluating the association between HPV and periodontitis found a strong association (odds ratio [OR] = 3.65, 95% confidence interval [CI] = 1.67–8.01) between any oral HPV infection and periodontitis, although an inconclusive positive association between periodontitis and oral high‐risk HPV infection (Ali et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…This chronic oral condition affects approximately 47% (~65 million) of adults in the United States (Eke et al, 2012). Nonetheless, epidemiologic studies are sparse and have yielded inconsistent results (Ortiz et al, 2018(Ortiz et al, , 2019Wiener et al, 2015). A recent review article highlights the contradictory evidence regarding the association between periodontitis and oral HPV infection.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of oral human papilloma virus detection methods among Hispanic adults

Castañeda‐Avila

Pérez

Vivaldi-Oliver

et al. 2021

Clinical & Exp Dental Res

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Objectives: Oral human papilloma virus (HPV) infection is associated with nearly three-quarters of all oropharyngeal cancers in the United States. Research also suggests its association with periodontal disease. There are limited studies evaluating differences in HPV detection methods; however, oral rinse is considered the most sensitive detection method. We compared HPV detection by self-collected oral rinse versus self-collected cytobrush and assessed whether the strength of association between periodontitis and HPV is modified by the collection method.Materials and Methods: Data from a cross-sectional study of Hispanic adults in Puerto Rico (n = 346) who provided oral rinse and cytobrush samples for oral HPV detection and were clinically evaluated for periodontitis. The agreement between the oral mouthwash and cytobrush methods was assessed using the Kappa (κ) statistic. Logistic regression models were used to determine if the association between HPV infection and other risk factors varied by oral sample collection method.Results: HPV prevalence was slightly higher using cytobrush than oral rinse (5.8% vs. 4.3%). The sensitivity of cytobrush to detect oral HPV was 64.7%, and the specificity was 97.4%. We observed a κ of 0.61 (95% confidence interval [CI]: 0.45-0.78), indicative of fair to good agreement between the two collection methods. The association between oral HPV infection and periodontitis severity was stronger when using the oral rinse collection method (odds ratio [OR] = 3.23, 95% CI:1.06-9.84); the association was not statistically significant for cytobrush (OR = 1.96, 95% CI: 0.68-5.65).Conclusions: These findings support the significance of choosing the most suitable collection method in oral HPV-related studies. Selecting the most appropriate collection method is an essential criterion in oral HPV-related studies.

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Association between virus infection and periodontitis: Evidence from the National Health and Nutrition Examination Survey 2009−2014

Fang,

Liu,

Mao

et al. 2024

Journal of Medical Virology

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Periodontitis is a cumulative inflammatory disease associated with multiple health conditions and various systemic diseases. As a common disease, virus infection along with its consequences has become a serious health burden. The study aims to evaluate the relationship between common viruses including hepatitis virus, human immunodeficiency virus (HIV), herpes simplex virus (HSV), human papillomavirus (HPV), and periodontitis. The data from the US National Health and Nutrition Examination Survey (NHANES) 2009−2014 was adopted and screened through, including 10 714 participants. Generalized linear regression was conducted to verify the relationships between the virus infections and periodontitis. Moreover, we also performed analyses in age and gender subgroups. The results suggested that the infection of HCV, HSV‐1, and HSV‐2 was significantly associated with the prevalence of periodontitis (odds ratio [OR] 1.46, 95% confidence interval [CI] 1.26−1.70; OR 1.09, 95% CI 1.05−1.13; OR 1.06, 95% CI 1.01 ‐ 1.11, respectively) and risk of developing moderate or severe periodontitis (OR 1.51, 95% CI 1.29−1.77; OR 1.08, 95% CI 1.04−1.12; OR 1.05, 95% CI 1.01−1.10, respectively) after adjusting all relevant co‐factors. Subgroup analyses revealed a steady association between periodontitis and hepatitis C virus (HCV) or HSV‐1 infection, while the relationship between HSV‐2 and HPV infection can also be found in some subgroups. The presence of HCV and HSV infection was found to be significantly associated with the prevalence of periodontitis, including moderate or severe cases. Moreover, the association of periodontitis and HPV infection can also be observed in people < 35 years.

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Is Human Papilloma Virus Infection Linked to Periodontitis? A Narrative Review

Cited by 9 publications

References 42 publications

The Crossroads of Periodontitis and Oral Squamous Cell Carcinoma: Immune Implications and Tumor Promoting Capacities

The Crossroads of Periodontitis and Oral Squamous Cell Carcinoma: Immune Implications and Tumor Promoting Capacities

Comparison of oral human papilloma virus detection methods among Hispanic adults

Association between virus infection and periodontitis: Evidence from the National Health and Nutrition Examination Survey 2009−2014

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