Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?

Heijer, Martin den; Gerrits, W. B. J.; Haak, H. L.; Wijermans, P. W.; Bos, Gerard M.J.; Blom, Henk J.; Rosendaal, Frits R.

doi:10.1016/s0140-6736(95)90008-x

Cited by 337 publications

(157 citation statements)

References 13 publications

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“…Thus the prevalence was higher in males as compared to females. This is consistent with finding in other studies [5,6,8].…”

Section: Percentage Of Patientssupporting

confidence: 94%

“…Elevated homocysteine concentrations have been found in 40% of patients with vascular disease and 35% of patients with venous thromboembolism [5]. A study by Den Heijer M showed a prevalence of hyperhomocysteinemia as 10% [6].…”

Section: Discussionmentioning

confidence: 99%

“…In classic homocysteinuria, half the vascular complications are of venous origin [3]. Various studies have proven that hyperhomocysteinemia is a risk factor for venous thrombosis [4,5]. Prevalence of hyperhomocysteinemia in cases of deep vein thrombosis has been extensively studied in the western population, but there are very few studies showing its prevalence in Indian population.…”

Section: Introductionmentioning

confidence: 99%

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A Cross-Sectional Study to Detect the Prevalence of Hyperhomocysteinemia in Cases of Deep Vein Thrombosis

et al. 2010

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Hyperhomocysteinemia is a known risk factor for the development of deep vein thrombosis (DVT). Various studies have been conducted in the western countries to know the prevalence of hyperhomocysteinemia in patients with DVT and in general population. There is no documented literature of the prevalence of hyperhomocysteinemia in Indian population. Thus the aim of this study was to determine the prevalence of hyperhomocysteinemia in cases of DVT in our population. To evaluate the prevalence of hyperhomocysteinemia, a prospective cross sectional study done on a total of 70 patients admitted in KLES Dr Prabhakar Kore hospital, Belgaum, India. DVT was confirmed by Doppler examination. Serum homocysteine was measured and the data analysed. Statistical significance was calculated using chi square test. A total of 70 patients were studied of which 53 were males and 17 were females. The prevalence of hyperhomocysteinemia among the cases of DVT was 31.428%.The prevalence among males was 35.85% and among females was 17.64%.There was statistically significant association between hyperhomocysteinemia and presence of ischaemic heart disease with a p value of 0.005 on chi square analysis. The prevalence of hyperhomocysteinemia in cases of deep vein thrombosis in our population was 31.428%. There was a statistically significant association between hyperhomocysteinemia and ischaemic heart disease.

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“…Thus the prevalence was higher in males as compared to females. This is consistent with finding in other studies [5,6,8].…”

Section: Percentage Of Patientssupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Cross-Sectional Study to Detect the Prevalence of Hyperhomocysteinemia in Cases of Deep Vein Thrombosis

et al. 2010

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“…For example, in the study by Falcon et al (1994) and Fermo et al (1995), the patients were very young (mean age 33 years), whereas Bienvenue et al (1993) had a control group with mean age 33 years and while the patients' mean age was 40 years. Den Heijer et al (1995) included patients only with recurrent thrombosis. In these four studies, patients with thrombosis at different locations were included, whereas in the study by Amundsen et al (1995) only patients with deep venous thrombosis were included and the patients had a mean age higher than in the other studies.…”

Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinemia and the MTHFR C677T mutation in central retinal vein occlusion

Larsson

Hultberg

Hillarp³

2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Background: Hyperhomocysteinemia is a factor that predisposes to thrombosis, and the C677T mutation in methylene-tetrahydrofolate reductase (MTHFR) is known to give increased plasma homocysteine. We wanted to investigate if these factors were overrepresented in a group of patients with central retinal vein occlusion. Methods: 116 patients with a history of central retinal vein occlusion were examined for the presence of hyperhomocysteinemia and the MTHFR C677T mutation. Results: Compared to the control groups, there was no significant increase, neither in plasma homocysteine nor in the frequency of the MTHFR C677T mutation in the patients. Even when we looked selectively at the young patients, age less than 50 years, no difference could be detected. Conclusion: It seems that neither hyperhomocysteinemia nor the MTHFR C677T mutation is an important risk factor for the aetiology of central retinal vein occlusion.

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“…20 We extended our patient group with 60 patients with documented premature cardiovascular disease. 13 To equalise the male ± female ratio between the patient and control group, all 280 male controls from a second population-based control group 21 were included.…”

Section: Study Populationmentioning

confidence: 99%

A 31 bp VNTR in the cystathionine β-synthase (CBS) gene is associated with reduced CBS activity and elevated post-load homocysteine levels

Lievers¹,

Kluijtmans²,

Heil³

et al. 2001

Eur J Hum Genet

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Molecular defects in genes encoding enzymes involved in homocysteine metabolism may account for mild hyperhomocysteinaemia, an independent and graded risk factor for cardiovascular disease (CVD). Although heterozygosity for cystathionine b-synthase (CBS) deficiency has been excluded as a major genetic cause of mild hyperhomocysteinaemia in vascular disease, mutations in (non-)coding DNA sequences may lead to a mildly decreased CBS expression and, consequently, to elevated plasma homocysteine levels. We assessed the association between a 31 bp VNTR, that spans the exon 13-intron 13 boundary of the CBS gene, and fasting, post-methionine load and increase upon methionine load plasma homocysteine levels in 190 patients with arterial occlusive disease, and in 381 controls. The 31 bp VNTR consists of 16, 17, 18, 19 or 21 repeat units and shows a significant increase in plasma homocysteine concentrations with an increasing number of repeat elements, in particular after methionine loading. In 26 vascular disease patients the relationship between this 31 bp VNTR and CBS enzyme activity in cultured fibroblasts was studied. The CBS enzyme activity decreased with increasing number of repeat units of the 31 bp VNTR. RT ± PCR experiments showed evidence of alternative splicing at the exon 13-intron 13 splice junction site. The 31 bp VNTR in the CBS gene is associated with post-methionine load hyperhomocysteinaemia that may predispose individuals to an increased risk of cardiovascular diseases.

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Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?

Cited by 337 publications

References 13 publications

A Cross-Sectional Study to Detect the Prevalence of Hyperhomocysteinemia in Cases of Deep Vein Thrombosis

A Cross-Sectional Study to Detect the Prevalence of Hyperhomocysteinemia in Cases of Deep Vein Thrombosis

Hyperhomocysteinemia and the MTHFR C677T mutation in central retinal vein occlusion

A 31 bp VNTR in the cystathionine β-synthase (CBS) gene is associated with reduced CBS activity and elevated post-load homocysteine levels

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