Is implantation of autologous chondrocytes superior to microfracture for articular-cartilage defects of the knee? A systematic review of 5-year follow-up data

Na, Yuyan; Shi, Yuting; Liu, Wanlin; Jia, Yanbo; Kong, Lingyue; Zhang, Ting; Han, Changxu; Ren, Yizhong

doi:10.1016/j.ijsu.2019.06.007

Cited by 60 publications

(39 citation statements)

References 42 publications

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“…The primary limitations associated with MSP and MSPþ techniques involve the size and type of defects that can be effectively treated, the potential sequelae to violation of the subchondral bone plate and dependency on bone marrow-derived cells for repair tissue formation, and the durability of the repair tissue and associated progression of pathology to early-onset knee OA. 5,69,75,[86][87][88][89] In addition, MSP has been associated with inferior results for subsequent revision cartilage repair or restoration techniques. [90][91][92] Autologous Chondrocyte Implantation and Matrix-Induced Autologous Chondrocyte Implantation…”

Section: Marrow Stimulation Proceduresmentioning

confidence: 99%

“…15,[93][94][95][96] These strategic advances have resulted in the ability to treat contained or semicontained defects up to 10 cm 2 and improve the durability and magnitude of functional outcomes compared with MSP. 49,88 MACI was developed in an attempt to address the technical difficulties, invasiveness, and relatively high-reoperation rates associated with ACI techniques that use a periosteal patch by seeding the cultured chondrocytes onto various collagen scaffolds. 75,[97][98][99][100][101] These MACI techniques have accomplished these goals to a large extent and are the preferred cell-based technique when available, feasible, and affordable.…”

Section: Marrow Stimulation Proceduresmentioning

confidence: 99%

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Clinical Application of the Basic Science of Articular Cartilage Pathology and Treatment

et al. 2020

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The joint is an organ with each tissue playing critical roles in health and disease. Intact articular cartilage is an exquisite tissue that withstands incredible biologic and biomechanical demands in allowing movement and function, which is why hyaline cartilage must be maintained within a very narrow range of biochemical composition and morphologic architecture to meet demands while maintaining health and integrity. Unfortunately, insult, injury, and/or aging can initiate a cascade of events that result in erosion, degradation, and loss of articular cartilage such that joint pain and dysfunction ensue. Importantly, articular cartilage pathology affects the health of the entire joint and therefore should not be considered or addressed in isolation. Treating articular cartilage lesions is challenging because left alone, the tissue is incapable of regeneration or highly functional and durable repair. Nonoperative treatments can alleviate symptoms associated with cartilage pathology but are not curative or lasting. Current surgical treatments range from stimulation of intrinsic repair to whole-surface and whole-joint restoration. Unfortunately, there is a relative paucity of prospective, randomized controlled, or well-designed cohort-based clinical trials with respect to cartilage repair and restoration surgeries, such that there is a gap in knowledge that must be addressed to determine optimal treatment strategies for this ubiquitous problem in orthopedic health care. This review article discusses the basic science rationale and principles that influence pathology, symptoms, treatment algorithms, and outcomes associated with articular cartilage defects in the knee.

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Section: Marrow Stimulation Proceduresmentioning

confidence: 99%

Section: Marrow Stimulation Proceduresmentioning

confidence: 99%

Clinical Application of the Basic Science of Articular Cartilage Pathology and Treatment

et al. 2020

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“…ACI was first described by Brittberg and colleagues in 1994 where patients' own cartilage tissues were harvested in one surgery to extract the chondrocytes, followed by cell culture expansion and injection into the defect site during a second surgery [231]. This treatment, along with the matrix induced autologous chondrocyte implantation (MACI) method [233], has shown positive clinical results for larger cartilage defects [234,235]. However, each method has its own limitations that have been previously discussed to great lengths [236][237][238][239][240].…”

Section: Stimulating Articular Cartilage Repairmentioning

confidence: 99%

Implementation of Endogenous and Exogenous Mesenchymal Progenitor Cells for Skeletal Tissue Regeneration and Repair

Desai

Jayasuriya

2020

Bioengineering

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Harnessing adult mesenchymal stem/progenitor cells to stimulate skeletal tissue repair is a strategy that is being actively investigated. While scientists continue to develop creative and thoughtful ways to utilize these cells for tissue repair, the vast majority of these methodologies can ultimately be categorized into two main approaches: (1) Facilitating the recruitment of endogenous host cells to the injury site; and (2) physically administering into the injury site cells themselves, exogenously, either by autologous or allogeneic implantation. The aim of this paper is to comprehensively review recent key literature on the use of these two approaches in stimulating healing and repair of different skeletal tissues. As expected, each of the two strategies have their own advantages and limitations (which we describe), especially when considering the diverse microenvironments of different skeletal tissues like bone, tendon/ligament, and cartilage/fibrocartilage. This paper also discusses stem/progenitor cells commonly used for repairing different skeletal tissues, and it lists ongoing clinical trials that have risen from the implementation of these cells and strategies. Lastly, we discuss our own thoughts on where the field is headed in the near future.

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“…An editorial review by Belk and McCarty [6] (2020) further stated that the comparison of MF with the historical ACI (P-ACI) may not be appropriate and it would be better if MF is compared with the newergeneration techniques of ACI. Na et al [31] (2019) did a systemic review of Level I and II studies comparing ACI with MF at mid-term. They reported that the newer generation ACI (C-ACI and MACI) had significantly better results than MF using KOOS, Tegner, and IKDC scores.…”

Section: Autologous Chondrocytes Implantation (Aci)mentioning

confidence: 99%

Recent advances and future trends in articular cartilage repair

Goyal¹

2020

JASSM

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Hyaline cartilage is an absolute necessity for a painless and a fully functional joint. A chondral or an osteochondral injury that doesn’t heal or doesn’t undergo a timely repair, eventually lead to arthritis. Many surgical options have been advocated and practiced in last three decades to treat the chondral and the osteochondral lesions. While some of the techniques are now available with the long term results, many techniques have evolved further to produce better results and lesser complications. Newer technologies have also been developed and they are looking promising. In 2020, it is timely to do a literature review of all the techniques suggested and practiced in last three decades and analyze their current status. It is also prudent to envisage, what can we expect in near future from the recent technologies on cartilage repair. The purpose of this paper is to update about the recent status of the established procedures and to review the future trends in cartilage repair.

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Is implantation of autologous chondrocytes superior to microfracture for articular-cartilage defects of the knee? A systematic review of 5-year follow-up data

Cited by 60 publications

References 42 publications

Clinical Application of the Basic Science of Articular Cartilage Pathology and Treatment

Clinical Application of the Basic Science of Articular Cartilage Pathology and Treatment

Implementation of Endogenous and Exogenous Mesenchymal Progenitor Cells for Skeletal Tissue Regeneration and Repair

Recent advances and future trends in articular cartilage repair

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