Is invasive lobular carcinoma different from invasive ductal carcinoma?

Mersin, Hakan; Yıldırım, Erol; Gülben, Kaptan; Berberoğlu, Uğur

doi:10.1053/ejso.2002.1423

Cited by 80 publications

(70 citation statements)

References 20 publications

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“…The impact of the LIC or DIC subtype on the risk of lymph node involvement remains debatable. 35 In a recent multiparameter analysis, Velanovich and Szymanski showed that LIC was not an independent predictor of lymph node involvement compared with DIC. 36 In the current series, the proportion of patients in whom the ASLN was the only involved lymph node was approximately the same for patients with DIC and patients with LIC (43 of 71 patients vs. 5 of 10 patients; difference not statistically significant).…”

Section: Accuracy Of Staging and Histologic Subtypementioning

confidence: 98%

Validation of axillary sentinel lymph node detection in the staging of early lobular invasive breast carcinoma

Classe

Loussouarn

Campion

et al. 2004

Cancer

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BACKGROUNDPrevious reports have shown that regional lymph node involvement in patients with early‐stage breast carcinoma can be evaluated by resection of axillary sentinel lymph nodes (ASLN). Axillary lymphadenectomy may be unnecessary in the absence of ASLN involvement. In the current study, the authors compared the results of ASLN resection in patients with lobular invasive carcinoma (LIC) with the results from patients with ductal invasive carcinoma (DIC) in terms of detection rates and false‐negative rates.METHODSFor ASLN detection, technetium 99m sulfur‐colloid and patent blue were injected around the tumor. Each patient underwent both ASLN resection and complete axillary lymphadenectomy. Detection rates and false‐negative rates were evaluated in patients with LIC and in patients with DIC.RESULTSTwo hundred forty‐three patients with invasive, early‐stage breast carcinoma were enrolled in the study (208 patients with DIC and 35 patients with LIC). The median patient age, pathologic tumor size, hormone receptor status, and rates of involved lymph nodes were equivalent for both groups. ASLN detection and false‐negative rates did not differ for patients with LIC and patients with DIC.CONCLUSIONSThe ASLN detection rate was not dependent on the pathologic type of invasive carcinoma. Pathologic examination of ASLN in patients with LIC and in patients with DIC predicted axillary lymph node status with the same predictive value in terms of lymph node metastasis. For patients with LIC, ASLN examination overestimated the rate of micrometastasis as diagnosed by immunohistochemical techniques. These results will require confirmation in larger studies. Cancer 2004;100:935–41. © 2004 American Cancer Society.

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Section: Accuracy Of Staging and Histologic Subtypementioning

confidence: 98%

Validation of axillary sentinel lymph node detection in the staging of early lobular invasive breast carcinoma

Classe

Loussouarn

Campion

et al. 2004

Cancer

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“…The treatment for stage-matched tumors is similar 18 but lobular carcinomas are often resistant to neoadjuvant therapy 21 . Although patients with ILCs are older, have low grade tumors and less lymphatic vascular invasion, they have no survival advantage compared with IDCs 16 . It is well documented that inactivating mutations and loss of heterozygosity of the CDH1 (E-cadherin gene), mapped to chromosome 16q22.1, are very frequent in ILC 2,24 , followed by the loss of protein expression 12,15 .…”

Section: Introductionmentioning

confidence: 99%

Novel Immunohistochemical Markers for the Differentiation of Lobular and Ductal Invasive Breast Carcinomas

Turashvili¹,

Bouchal²,

Ehrmann³

et al. 2007

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims. Invasive ductal and lobular carcinomas are the most common histological types of breast cancer. The loss of E-cadherin expression has been suggested to be the most reliable marker for invasive lobular carcinoma. The aim of our study was to identify the diagnostic usefulness of novel markers in the diff erentiation of these tumor types.Methods. We examined tissue microarrays (TMA) which were constructed from surgical specimens of 119 breast cancer patients. TMA consisted of 80 ductal carcinomas, 29 lobular carcinomas and special type cancers. TMA sections were stained using standard immunohistochemical methods. Monoclonal mouse antibodies against E-cadherin, cytokeratin 5/6 and 17, and polyclonal mouse antibodies against EMP1, DDR1, PRKCI and DVL1 were used.Results. E-cadherin was absent in 93.3 % of lobular tumors compared with only 15 % of ductal tumors (p < 0.0001). EMP1 and DVL1 were overexpressed in lobular tumors (93.1 % and 96.5 %, respectively), whereas PRKCI and DDR1 were positive in ductal cancers (90 % and 96.2 %, respectively). Reduced expression or absence of both cytokeratins 5/6 and 17 was found in both tumor tissues in comparison to normal terminal duct lobular units (p < 0.0001).Conclusions. Apart from the well-established marker, E-cadherin, proteins examined on TMA slides by immunohistochemistry (EMP1, DVL1, DDR1, PRKCI) may represent novel tissue markers helpful in the diff erentiation of ductal and lobular breast cancers. Further studies with larger sets of patients are desirable, to verify the complete immunohistochemical profi les of various histological types of breast cancer and determine the prognostic and predictive signifi cance of novel markers. BACKGROUND

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“…The incidence of oestrogen and progesterone receptors positivity in ILC varies from 43 to 96% and 42 to 82% respectively which is higher than IDC (Coradini et al 2002, Cocquyt et al 2003, Mersin et al 2003, Arpino et al 2004, Korhonen et al 2004, Molland et al 2004; Table 4). These data are consistent with the growing body of evidence that HRT use is associated with a greater increase in risk of ILC when compared with IDC (Li et al 2000a,b, 2003a,b,c, Chen et al 2002, Daling et al 2002, Newcomb et al 2002, Newcomer et al 2003.…”

Section: Biological and Clinical Features Of Invasive Lobular Cancermentioning

confidence: 99%

“…ILC occurs more frequently in older patients and is larger in size than IDC (Sastre-Garau et al 1996, Mersin et al 2003, Arpino et al 2004. The older age at diagnosis of patients with ILC may be due to a low proliferative rate or greater difficulties in detecting ILC.…”

Section: Biological and Clinical Features Of Invasive Lobular Cancermentioning

confidence: 99%

“…These diagnostic difficulties may also account for the higher incidence of ILCs reported in patients with initially metastatic breast carcinoma (Jimeno et al 2004). Despite the larger size of ILC, it has been observed that the rate of lymph nodal involvement is the same or even slightly lower when compared with IDC (Mersin et al 2003, Arpino et al 2004, Korhonen et al 2004.…”

Section: Biological and Clinical Features Of Invasive Lobular Cancermentioning

confidence: 99%

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Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: implications for diagnosis, surgical and medical treatment

Biglia¹,

Mariani²,

Sgrò³

et al. 2007

Endocr Relat Cancer

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A growing body of evidence support the association between the use of hormone replacement therapy (HRT) and a higher risk of both invasive lobular carcinoma (ILC) and invasive ductal-lobular mixed carcinoma (IDLC). Overall biological and clinical features of ILC entail a more cautious diagnostic and therapeutic approach as compared with invasive ductal carcinoma (IDC). ILCs are more frequently multifocal, multicentric and/or bilateral. Mammography and ultrasound show, therefore, significant limitations, while the higher sensitivity of magnetic resonance imaging in the detection of multifocal and/or multicentric lesions seems to improve the accuracy of preoperative staging of ILCs. Early diagnosis is even more challenging because the difficult in the localization and the sparse cellularity of lobular tumours may determine a false negative core biopsy. ILC is characterized by low proliferative activity, C-ErbB-2 negativity, bcl-2 positivity, p53 and VEGF negativity, oestrogen and progesterone positive receptors, low grade and low likelihood of lymphaticvascular invasion. However, this more favourable biological behaviour does not reflect into a better disease-free and overall survival as compared with IDC. Since lobular histology is associated with a higher risk of positive margins, mastectomy is often preferred to breast conservative surgery. Moreover, only few patients with ILC achieve a pathologic response to preoperative chemotherapy and, therefore, in most patients mastectomy can be regarded as the safer surgical treatment. The preoperative staging and the follow-up of patients with ILC are also complicated by the particular metastatic pattern of such histotype. In fact, metastases are more frequently distributed to the gastrointestinal tract, peritoneum/retroperitoneum and gynaecological organs than in IDC.

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Is invasive lobular carcinoma different from invasive ductal carcinoma?

Cited by 80 publications

References 20 publications

Validation of axillary sentinel lymph node detection in the staging of early lobular invasive breast carcinoma

Validation of axillary sentinel lymph node detection in the staging of early lobular invasive breast carcinoma

Novel Immunohistochemical Markers for the Differentiation of Lobular and Ductal Invasive Breast Carcinomas

Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: implications for diagnosis, surgical and medical treatment

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