Is ionizing radiation a risk factor for anxiety in employees?

Mansıroğlu, Aslı Kurtar; Erer, Murat; Cosgun, Mehmet; Sıncer, İsa; Güneş, Yılmaz

doi:10.1590/1806-9282.66.12.1685

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…Radiation exposure-associated emotional disturbances are common and manifest as anxiety and depression, among other symptoms ( 44 , 45 ). Therefore, we examined emotion-related symptoms in the present study.…”

Section: Discussionmentioning

confidence: 99%

Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice

et al. 2022

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Radiological therapy/examination is the primary source of artificial radiation exposure in humans. While its application has contributed to major advances in disease diagnosis and treatment, ionizing radiation exposure is associated with ovarian damage. The use of natural products, either alone or as an adjunct, has become increasingly common for reducing the side effects of radiological therapy during disease treatment. Herein, we explored the protective effect of folic acid (FA), a widely used B vitamin, against radiation-induced ovarian injury and its mechanism of action. Female mice with normal ovarian function were randomly divided into control, FA, radiation, and radiation + FA groups. The intervention strategy included daily intragastric administration of FA (5 mg/kg) for 3 weeks prior to radiation exposure. Mice in the radiation and radiation + FA groups received a single dose of 5 Gy X-ray irradiation. Changes in the estrous cycle were then recorded, and ovarian tissues were collected. Pathophysiological changes as well as reproductive and endocrine-related indexes were determined via H&E staining, immunohistochemistry, Western blot, and ELISA. The reproductive performance and emotional symptoms of animals were also monitored. Our results indicated that FA intervention effectively alleviated ovarian damage, leading to more regular estrous cycles, lesser impairment of follicular morphology and endocrine status, as well as greater germ cell preservation. Reduced levels of oxidative stress, inflammation, and enhanced DNA repair were associated these changes. FA pre-administration improved the reproductive performance, leading to higher pregnancy rates and greater litter sizes. Further, the anxiety levels of animals were significantly reduced. Our results indicate that FA pre-administration significantly alleviates radiation-induced ovarian damage in rodents, highlighting its potential as a protective strategy against radiation exposure in the female population.

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Section: Discussionmentioning

confidence: 99%

Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice

et al. 2022

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“…We read with great interest the study by Asli Kurtar Mansiroglu et al 1 , in which they demonstrated that radiation is likely to be a risk factor for anxiety among hospital staff, although, in our opinion, the author should combine more clinical cases to confirm this view.…”

Section: Dear Editormentioning

confidence: 95%

“…

Dear Editor,We read with great interest the study by Asli Kurtar Mansiroglu et al 1 , in which they demonstrated that radiation is likely to be a risk factor for anxiety among hospital staff, although, in our opinion, the author should combine more clinical cases to confirm this view.First, although the two groups of research objects selected by the researchers come from the same working environment, there are still some differences, which will affect the accuracy of the research results; the author should choose a more similar working environment to reduce the interference of relevant influencing factors and research conclusions.Second, the author's conclusion is only to prove that radiation is one of the risk factors affecting employee anxiety. However, the further influencing mechanism is not determined.

…”

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confidence: 99%

Comment on “Is ionizing radiation a risk factor for anxiety in employees?”

Zhang

Xue

2021

Rev. Assoc. Med. Bras.

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Dear Editor,We read with great interest the study by Asli Kurtar Mansiroglu et al. 1 , in which they demonstrated that radiation is likely to be a risk factor for anxiety among hospital staff, although, in our opinion, the author should combine more clinical cases to confirm this view.First, although the two groups of research objects selected by the researchers come from the same working environment, there are still some differences, which will affect the accuracy of the research results; the author should choose a more similar working environment to reduce the interference of relevant influencing factors and research conclusions.Second, the author's conclusion is only to prove that radiation is one of the risk factors affecting employee anxiety. However, the further influencing mechanism is not determined.

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“…Although ionizing radiation (IR) is known to be harmful, the use of radiation is increasing in many as of industry and medicine ( 1 – 3 ). Because IR-induced cellular damage comprises a very diverse and complex sequence of molecular events, it is very difficult to protect and prevent ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Radioprotection of deinococcal exopolysaccharide BRD125 by regenerating hematopoietic stem cells

Park

Lee

et al. 2022

Front. Oncol.

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There is a substantial need for the development of biomaterials for protecting hematopoietic stem cells and enhancing hematopoiesis after radiation damage. Bacterial exopolysaccharide (EPS) has been shown to be very attractive to researchers as a radioprotectant owing to its high antioxidant, anti-cancer, and limited adverse effects. In the present study, we isolated EPS from a novel strain, Deinococcus radiodurans BRD125, which produces EPS in high abundance, and investigated its applicability as a radioprotective biomaterial. We found that EPS isolated from EPS-rich D. radiodurans BRD125 (DeinoPol-BRD125) had an excellent free-radical scavenging effect and reduced irradiation-induced apoptosis. In addition, bone-marrow and spleen-cell apoptosis in irradiated mice were significantly reduced by DeinoPol-BRD125 administration. DeinoPol-BRD125 enhanced the expression of hematopoiesis-related cytokines such as GM-CSF, G-GSF, M-CSF, and SCF, thereby enhancing hematopoietic stem cells protection and regeneration. Taken together, our findings are the first to report the immunological mechanism of a novel radioprotectant, DeinoPol-BRD125, which might constitute an ideal radioprotective and radiation mitigating agent as a supplement drug during radiotherapy.

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Is ionizing radiation a risk factor for anxiety in employees?

Cited by 5 publications

References 16 publications

Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice

Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice

Comment on “Is ionizing radiation a risk factor for anxiety in employees?”

Radioprotection of deinococcal exopolysaccharide BRD125 by regenerating hematopoietic stem cells

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