Is it Possible to Diagnose Pituitary-Dependent Cushing's Disease?

Howlett, Trevor A.; Rees, Lesley

doi:10.1177/000456328502200602

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Differential Diagnosis Of Acth-dependent Cushing’s Syndrome1

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Cited by 19 publications

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“…In up to 70% of cases, occult ectopic tumours may express and co-secrete one or more additional peptides such as calcitonin, somatostatin, gastrin, pancreatic polypeptide, vasoactive intestinal peptide, glucagon, human chorionic gonadotropin-β, α-fetoprotein, α-subunit, neuron-specific enolase, growth hormone releasing hormone, CRH and/or carcinoembryonic antigen [64, 65]. Thus, measurement of these specific peptides may sometimes be useful.…”

Section: Differential Diagnosis Of Acth-dependent Cushing’s Syndromementioning

confidence: 99%

The Diagnosis and Differential Diagnosis of Cushing’s Syndrome<footref rid="foot01"><sup>1</sup></footref>

Newell‐Price

Jørgensen²,

Grossman³

1999

Horm Res Paediatr

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Cushing’s syndrome is defined as the symptoms and signs of glucocorticoid excess, but the precise diagnosis may be difficult to establish and harder to localise. The clinicial, biochemical and imaging features of the syndrome are discussed in the light of our own extensive experience and the published literature. We describe the optimal diagnostic routines currently recommended in major centres, and analyse the sensitivities and specialities of the various tests employed. Only by means of establishing a precise diagnosis can the disorder be successfully treated.

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Section: Differential Diagnosis Of Acth-dependent Cushing’s Syndromementioning

confidence: 99%