Is it possible to predict hypothyroidism after thyroid lobectomy through thyrotropin, thyroglobulin, anti-thyroglobulin, and anti-microsomal antibody?

Cho, Jin Seong; Shin, Sun Hyoung; Song, Young-Ju; Kim, Hee Kyung; Park, Min Ho; Yoon, Jung Han; Jegal, Young Jong

doi:10.4174/jkss.2011.81.6.380

Cited by 23 publications

(35 citation statements)

References 16 publications

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“…For patients who had preoperative low normal TSH or nonthyroiditis and the first visit (6 weeks) had normal TSH result, thyroid function might be monitored every six months for the first year and on a yearly basis thereafter, since it is rarely developing hypothyroidism. However, patients with normal TSH level at the first post-operative visit but with numerous risk backgrounds such as preoperative high normal serum TSH, elevated thyroid antibodies titers, or thyroiditis in the resected thyroid, should have serum TSH monitoring follow-ups that include scheduled serial TSH draws at 3, 6, 12 months and on a year lybasis post-operatively to detect the possible late development of hypothyroidism 4,12,19 .…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Post-Hemithyroidectomy hypothyroidism

Awual

Hasan²,

Reza³

et al. 2020

Bangladesh J of Otorhinolaryngology

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Objective: To evaluate the incidence of post-hemithyroidectomy hypothyroidism and identify possible risk factors that indicates which patients require thyroid function monitoring after surgery. Methods: A prospective study of patients with benign, non-toxic thyroid disease undergoing hemithyroidectomy between January 2017 and July 2019 in the Department of Otolaryngology and Head-Neck Surgery, Sir Salimullah Medical College Mitford Hospital, Dhaka. All patients were in euthyroid state preoperatively.Thyroid specimens were examined for pathological diagnosis and thyroid function was evaluated again six weeks after surgery. Results: All had normal preoperative thyroid function. Six weeks after surgery, 10 (22.22%) of the cases developed hypothyroidism (6.66% overt or symptomatic hypothyroidism and 15.56% subclinical hypothyroidism). The mean preoperative TSH level was significantly higher in the hypothyroid group than in the euthyroid group (2.1±1.1 vs 1.3±0.7mIU/L, p<0.01).Seven of patients with preoperative thyroid stimulating hormone (TSH) level more than or equal to 2 mIU/L developed hypothyroidism in comparison to only 3 of those with preoperative TSH <2 mIU/L (odds ratio 11.3). Conclusion: Ten (22.22%) patients in the present study developed hypothyroidism after hemithyroidectomy. Preoperative TSH more than or equal 2 mIU/L, elevation of thyroid antibodies and thyroiditiswarrant post-operative close TSH monitoring. Awareness of such risk factors for post-operative hypothyroidism would improve patients care and reduce complications. Bangladesh J Otorhinolaryngol; October 2020; 26(2): 95-101

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Section: Resultsmentioning

confidence: 99%

Evaluation of Post-Hemithyroidectomy hypothyroidism

Awual

Hasan²,

Reza³

et al. 2020

Bangladesh J of Otorhinolaryngology

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“…The incidence of postoperative hypothyroidism following 15 thyroidectomy ranges from 21.1% to 64.2% in the literature.…”

Section: Discussionmentioning

confidence: 99%

A Prospective Study About the Surgical Management of Thyroid Carcinoma

Dubey

Churendra

2019

PIJR

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INTRODUCTION : Thyroid cancer is one of the most common endocrine cancer and has the highest mortality among endocrine neoplasms. In India, its incidence is between 0.8–2 per 1,00,000 population. Early diagnosis and treatment remain the cornerstone of management to decrease the mortality rates. lack of prospective randomized trials, the management of these cancers generates tremendous controversy. study was planned to assess & evaluate the management of various thyroid carcinomas. METHODS: A total of 40 patients were selected which were pathologically / histologically proven cases of Thyroid carcinoma in this Prospective study design in 2.5 years. Detailed Clinical Examination was done & Prior to surgery all the patients went through investigations. Subjects included both the genders , all age groups including pediatric and geriatric age group and all classes of socio economic strata. RESULTS: No of female patients were 30 and male patients 10.Male :female ratio in this study was 1:3.FNAC / Biopsy / Cytology detected papillary carcinoma in 26 patients (65%) ,follicular neoplasm in 11 patients (27.5%) ,2 (5%) patients of anaplastic and one (2.5%) of medullary carcinoma. 86.6% of the patients had a firm gland & hard gland and rest presented with a soft gland on palpation.Total Thyroidectomy with cervical block dissection was performed in 32 (80%) cases .Rest of the 20 % were dealt with Sub total Thyroidectomy with cervical block dissection. CONCLUSION: Most of the cancers present as a slow growing goiter for few months to few years duration.Most of the cancers are of papillary carcinoma type , FNAC detects the majority of the cancers and is an important diagnostic test.Thyroid cancers have a good prognosis as most of the patients present as Stage I disease & most of the patients require total thyroidectomy with or without lymph node dissection followed by radio iodine ablation as treatment.Thyroid cancer,irrespective of the extent of disease,has good prognosis

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“…Hypothyroidism following thyroid lobectomy has been highlighted in several studies that show different prevalence rates and risk factors. 1 , 3 – 6 , 9 Vaiman et al., 2008 3 reported that out of 1 051 hemithyroidectomy cases, 28% developed permanent postoperative hypothyroidism and 46% developed temporary hypothyroidism, all of which required postsurgical thyroxine. A hypothyroidism prevalence rate of 47% following hemithyroidectomy has also been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Thyroid lobectomy has become common practice for some thyroid diseases, 1 and is indicated in cases of a single thyroid nodule, single toxic adenoma and, rarely, unilateral goitre. 2 The nodule in the vast majority of cases is benign or has suspicious or indeterminate characteristics on fine-needle aspiration cytology.…”

Section: Introductionmentioning

confidence: 99%

“… 3 For example, risk factors including age, high serum thyrotropin (thyroid stimulating hormone [TSH]) levels, lower free thyroxine (T4) levels, and the preoperative presence of thyroid antibodies have been suggested. 1 , 4 – 8 A few studies, however, do not support the involvement of some of these risk factors. 6 , 9 Published investigations into the postoperative effect of isthmus preservation during thyroid lobectomy remain scarce.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of hypothyroidism among patients with isthmus-preserved thyroid lobectomy

Salih

2018

J Int Med Res

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ObjectiveTo investigate the prevalence of hypothyroidism following thyroid lobectomy with isthmus preservation.MethodsThis retrospective, case series study included patients who had undergone thyroid lobectomy with preserved isthmus that was reversed onto the contralateral lobe. Neck ultrasound was performed in all patients and the patients were followed for 2 years.ResultsOut of 170 patients enrolled into the study, three were excluded due to preoperative hypothyroidism and one due to isthmusectomy; of the remaining 166 included in the final analyses, 139 patients (83.7%) were female, 27 (16.3%) were male, and patient age ranged between 17 and 77 years. The indication for intervention was thyroid swelling in 141 patients (84.9%). Final diagnoses following histopathological examination comprised benign lesion in 145 cases (87.3%), malignancy (follicular carcinoma and papillary thyroid carcinoma) in 12 cases (7.2%) and thyroiditis in nine cases (5.4%). During the 2-year post-surgery follow-up, 165 patients (99.4%) were euthyroid and one patient (0.6%) developed hypothyroidism.ConclusionPostoperative hypothyroidism following thyroid lobectomy appears to be very rare when the isthmus is preserved and reversed onto the contralateral lobe.

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Is it possible to predict hypothyroidism after thyroid lobectomy through thyrotropin, thyroglobulin, anti-thyroglobulin, and anti-microsomal antibody?

Cited by 23 publications

References 16 publications

Evaluation of Post-Hemithyroidectomy hypothyroidism

Evaluation of Post-Hemithyroidectomy hypothyroidism

A Prospective Study About the Surgical Management of Thyroid Carcinoma

Prevalence of hypothyroidism among patients with isthmus-preserved thyroid lobectomy

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