Is it possible to predict para-aortic lymph node metastasis in endometrial cancer?

Turan, Taner; Hızlı, Deniz; Sarıcı, Saim Furkan; Boran, Nurettin; Gündoğdu, Burcu; Karadağ, Burak; Tulunay, Gökhan; Köse, Mehmet

doi:10.1016/j.ejogrb.2011.04.031

Cited by 49 publications

(33 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Adnexal metastasis is associated with omental metastasis (31) and para-aortic lymph node metastasis (32). The risk of tumor recurrence in patients with adnexal involvement is 4.29-fold higher compared with patients without adnexal involvement, which is consistent with the results demonstrated by Hétu et al (33), who reported that patients with metastasis to the adnexa have a higher risk of recurrence.…”

Section: A B Csupporting

confidence: 82%

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Wang

Nan

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. The aim of the present study was to determine risk factors associated with recurrence and survival in patients with grade 3 endometrioid endometrial carcinoma (G3EEC). A retrospective analysis of 117 patients with G3EEC, who were admitted to the Obstetrics and Gynecology Hospital of Fudan University between January 2000 and December 2011, was performed. The χ 2 test or Fisher's exact test were used for the comparison of categorical variables. Kaplan-Meier method was used for estimating recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) rates. Univariate and multivariate Cox proportional hazards model were used to assess the prognostic significance of various patient characteristics. In 117 patients, 16 patients (13.7%) had tumor recurrence, of which 6 (37.5%) developed local-regional recurrence and 10 (62.5%) developed distant recurrence. Out of the 16 patients with tumor recurrence, 14 (87.5%) had a recurrence within 3 years of surgery. Statistically significant characteristics affecting RFS, DSS and OS rates were outer half myometrial invasion (MI ≥50%), advanced International Federation of Gynecology and Obstetrics stage, positive lymph node metastasis (PLNM), lymph vascular space invasion, adnexal involvement and characterization as a high-risk group, according to the Gynecologic Oncology Group 99 stratification algorithm. RFS was associated with the depth of cervical mucosa (stromal) involvement. Furthermore, in the multivariate Cox proportional hazards model, significant independent adverse factors for RFS and DSS included MI ≥50% and adnexal involvement. For OS, there were no statistically significant prognostic factors. In conclusion, MI ≥50% and adnexal involvement are independent prognostic factors for RFS and DSS in G3EEC patients.

show abstract

Section: A B Csupporting

confidence: 82%

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Wang

Nan

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

show abstract

“…We also found that the most common site of initial recurrence was distant, similar to Turan et al's study 20. We demonstrated that histologic grade and depth of myometrial invasion were independent predictors of overall survival and progression-free survival.…”

Section: Discussionsupporting

confidence: 89%

Treatment outcomes of endometrial cancer patients with paraaortic lymph node metastasis: a multi-institutional analysis

Onal

Yıldırım

Sarı

et al. 2019

Int J Gynecol Cancer

View full text Add to dashboard Cite

ObjectiveTo analyze the prognostic factors and treatment outcomes in endometrial cancer patients with paraaortic lymph node metastasis.MethodsData from four centers were collected retrospectively for 92 patients with endometrial cancer treated with combined radiotherapy and chemotherapy or adjuvant radiotherapy alone postoperatively, delivered by either the sandwich or sequential method. Prognostic factors affecting overall survival and progression-free survival were analyzed.ResultsThe 5-year overall survival and progression-free survival rates were 35 % and 33 %, respectively, after a median follow-up time of 33 months. The 5-year overall survival and progression-free survival rates were significantly higher in patients receiving radiotherapy and chemotherapy postoperatively compared with patients treated with adjuvant radiotherapy alone (P < 0.001 and P < 0.001, respectively). In a subgroup analysis of patients treated with adjuvant combined chemotherapy and radiotherapy, the 5-year overall survival and progression-free survival rates were significantly higher in patients receiving chemotherapy and radiotherapy via the sandwich method compared with patients treated with sequential chemotherapy and radiotherapy (P = 0.02 and P = 0.03, respectively). In the univariate analysis, in addition to treatment strategy, pathology, depth of myometrial invasion, and tumor grade were significant prognostic factors for both overall survival and progression-free survival. In the multivariate analysis, grade III disease, myometrial invasion greater than or equal to 50%, and adjuvant radiotherapy alone were negative predictors for both overall survival and progression-free survival.ConclusionWe demonstrated that adjuvant combined treatment including radiotherapyand chemotherapy significantly increases overall survival and progression-free survival rates compared with postoperative pelvic and paraaortic radiotherapy.

show abstract

“…However, previous studies have shown that LVSI could be determined by frozen section examination with high accuracy by a gynecologic pathologist. 19,21,22 In light of these findings, we suggest that LVSI could be considered with traditional low-risk clinicopathological features (endometrioid histology, grade myometrial invasion, and tumor size) during the frozen section examinations to predict lymph node metastasis. Even if obtaining reliable LVSI data from frozen section is difficult, tumor size alone might be used as a surrogate at the time of surgery to provide additional information to triage patients for full surgical staging.…”

Section: Discussionmentioning

confidence: 93%

“…Median number of removed lymph nodes was 26 (interquartile [IQ] range, 19). Median number of paraaortic and pelvic lymph nodes removed were 5 (IQ range, 5) and 22 (IQ range, 15), respectively.…”

Section: Resultsmentioning

confidence: 99%

Incidence of Lymph Node Metastasis in Surgically Staged FIGO IA G1/G2 Endometrial Cancer With a Tumor Size of More Than 2 cm

Boyraz

Salman

Gültekin

et al. 2017

International Journal of Gynecological Cancer

View full text Add to dashboard Cite

show abstract

Is it possible to predict para-aortic lymph node metastasis in endometrial cancer?

Cited by 49 publications

References 24 publications

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Treatment outcomes of endometrial cancer patients with paraaortic lymph node metastasis: a multi-institutional analysis

Incidence of Lymph Node Metastasis in Surgically Staged FIGO IA G1/G2 Endometrial Cancer With a Tumor Size of More Than 2 cm

Contact Info

Product

Resources

About