Is it worth expending energy to convert biliverdin into bilirubin?

Nam, Joon; Lee, Yonghyun; Yang, Yunqing; Jeong, Seongkeun; Kim, Wooseong; Yoo, Jung‐Woo; Moon, Jeon Ok; Lee, Chang-Yong; Chung, Hae Young; Kim, Min Soo; Jon, Sangyong; Jung, Yunjin

doi:10.1016/j.freeradbiomed.2018.06.010

Cited by 23 publications

(14 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the degradation pathway of heme occurs in virtually all tissues, since heme-containing proteins are ubiquitously distributed and undergo physiological turnover. Notably, also the generation of bilirubin in peripheral tissues has been proposed to be protective (Sedlak et al, 2009;Takeda et al, 2015;Nam et al, 2018), and bilirubin derived from vascular cells could modulate tissue microenvironment playing both antioxidant and antiinflammatory roles (Siow et al, 1999;He et al, 2015). We pointed out this aspect in the different contexts analyzed in the present review.…”

Section: Introductionmentioning

confidence: 83%

“…Furthermore, BLVRA contributes to the antioxidant properties of the HMOX1/bilirubin system, as pointed out by Jansen and Daiber (2012). Importantly, Nam et al (2018) have recently discussed the physiological relevance of the conversion of biliverdin to bilirubin through an energy consuming reaction, highlighting that the reaction carried out by BLVRA dramatically increases the electrophilicity of bilirubin in comparison to biliverdin. This enables its binding to thiol reactive cysteines on Keap1, favoring Nrf2-dependent gene induction and thereby generating a positive feedback of cytoprotection.…”

Section: Biosynthesis Metabolism Bioavailability and Activitymentioning

confidence: 94%

See 1 more Smart Citation

Heme Oxygenase Dependent Bilirubin Generation in Vascular Cells: A Role in Preventing Endothelial Dysfunction in Local Tissue Microenvironment?

2020

View full text Add to dashboard Cite

Among antioxidants in the human body, bilirubin has been recognized over the past 20 years to afford protection against different chronic conditions, including inflammation and cardiovascular disease. Moderate increases in plasma concentration and cellular bilirubin generation from metabolism of heme via heme oxygenase (HMOX) in virtually all tissues can modulate endothelial and vascular function and exert antioxidant and antiinflammatory roles. This review aims to provide an up-to-date and critical overview of the molecular mechanisms by which bilirubin derived from plasma or from HMOX1 activation in vascular cells affects endothelial function. Understanding the molecular actions of bilirubin may critically improve the management not only of key cardiovascular diseases, but also provide insights into a broad spectrum of pathologies driven by endothelial dysfunction. In this context, therapeutic interventions aimed at mildly increasing serum bilirubin as well as bilirubin generated endogenously by endothelial HMOX1 should be considered.

show abstract

Section: Introductionmentioning

confidence: 83%

Section: Biosynthesis Metabolism Bioavailability and Activitymentioning

confidence: 94%

Heme Oxygenase Dependent Bilirubin Generation in Vascular Cells: A Role in Preventing Endothelial Dysfunction in Local Tissue Microenvironment?

2020

View full text Add to dashboard Cite

show abstract

“…BV, the greenish, water-soluble metabolite produced by the catalytic degradation of heme by HMOX [ 11 , 133 ], is probably the least studied product of this enzyme. Due to its rapid reduction to UCB by BLVR [ 134 , 135 ], BV is almost undetectable in serum and cells [ 90 , 136 , 137 ].…”

Section: The Yellow Players (Yp)mentioning

confidence: 99%

“…Unlike BV that has a double bond between the inner pyrrole rings, UCB contains a single bond. This UCB electrophilic characteristic accounts for its ability to react with thiol compounds characteristic of many transcription nuclear factors [ 133 ]. Thus, UCB may modulate key signalling pathways [ 107 , 112 , 113 ] ( Table 2 ).…”

Section: The Yellow Players (Yp)mentioning

confidence: 99%

The Role of Bilirubin and the Other “Yellow Players” in Neurodegenerative Diseases

et al. 2020

View full text Add to dashboard Cite

Bilirubin is a yellow endogenous derivate of the heme catabolism. Since the 1980s, it has been recognized as one of the most potent antioxidants in nature, able to counteract 10,000× higher intracellular concentrations of H2O2. In the recent years, not only bilirubin, but also its precursor biliverdin, and the enzymes involved in their productions (namely heme oxygenase and biliverdin reductase; altogether the “yellow players”—YPs) have been recognized playing a protective role in diseases characterized by a chronic prooxidant status. Based on that, there is an ongoing effort in inducing their activity as a therapeutic option. Nevertheless, the understanding of their specific contributions to pathological conditions of the central nervous system (CNS) and their role in these diseases are limited. In this review, we will focus on the most recent evidence linking the role of the YPs specifically to neurodegenerative and neurological conditions. Both the protective, as well as potentially worsening effects of the YP’s activity will be discussed.

show abstract

“…Bilirubin is a catabolic product of the heme metabolism that is formed by the degradation of heme component of hemoglobin and is released during the breakdown of red blood cells (Nam et al, 2018). Hyperbilirubinemia may occur as a result of both hepatocellular and cholestatic injury (Woreta & Alqahtani, 2014).…”

Section: Liver Toxicitymentioning

confidence: 99%

Effect of Introducing the Jordanian Common Rue (Ruta chalepensis L.) on Liver Enzymes and Lipid Peroxidation in Adult Male Sprague Dawley Rats Toxified With Paracetamol

Abdelrahim¹,

Takruri²,

Al‐Ismail³

2020

JAS

View full text Add to dashboard Cite

This study aimed to determine the effect of Ruta chalepensis L. plant on liver enzymes, liver weight and lipid peroxidation using rats toxified with paracetamol. An animal experiment was conducted using five groups of Sprague Dawley rats, 9 rats each. The groups were fed: Normal diet, high cholesterol diet, with or without the plant or the liver toxicant paracetamol (PCM). The experiment lasted six weeks; at the end of the sixth week; a single dose of 3 g paracetamol/kg body weight was given for rats of two groups, then blood and liver samples were collected. The hepatoprotective effect of the plant was evaluated using aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBL) levels as indicators. This study finds that the groups to which plant and PCM were given had significantly lower MDA levels in comparison with other groups that didn't receive plant before PCM toxification. Tested liver enzymes levels were significantly (P < 0.05) lowered by the introduction of plant to the diet. Introducing PCM without ingestion of plant in the diet significantly (P < 0.05) increased the rats absolute liver weight. It is concluded that the use of Ruta chalepensis L. plant significantly lowered hepatic toxicity as indicated by the liver enzymes levels. Also, the plant lowered the MDA level and liver weight. The ingestion of the plant can be significantly protective against hepatic injury.

show abstract

Is it worth expending energy to convert biliverdin into bilirubin?

Cited by 23 publications

References 33 publications

Heme Oxygenase Dependent Bilirubin Generation in Vascular Cells: A Role in Preventing Endothelial Dysfunction in Local Tissue Microenvironment?

Heme Oxygenase Dependent Bilirubin Generation in Vascular Cells: A Role in Preventing Endothelial Dysfunction in Local Tissue Microenvironment?

The Role of Bilirubin and the Other “Yellow Players” in Neurodegenerative Diseases

Effect of Introducing the Jordanian Common Rue (Ruta chalepensis L.) on Liver Enzymes and Lipid Peroxidation in Adult Male Sprague Dawley Rats Toxified With Paracetamol

Contact Info

Product

Resources

About