Is Laparoscopic Visualization Sufficient for the Diagnosis of Endometriosis?

Gratton, Sara-Michelle; Choudhry, Abdul Jamil; Chen, Innie

doi:10.1016/j.jogc.2019.02.186

Cited by 2 publications

(2 citation statements)

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“…Laparoscopy permits two diagnostic techniques: direct visualization of endometriosis and histological assessment via biopsy. Often, these are combined because biopsy is usually reliant on a visual diagnosis 23 .…”

Section: Diagnosing Endometriosis: Presence or Absencementioning

confidence: 99%

Strengths and limitations of diagnostic tools for endometriosis and relevance in diagnostic test accuracy research

Pascoal

Wessels

Aas-Eng

et al. 2022

Ultrasound in Obstet & Gyne

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Endometriosis is a chronic systemic disease that can cause pain, infertility and reduced quality of life. Diagnosing endometriosis remains challenging, which yields diagnostic delays for patients. Research on diagnostic test accuracy in endometriosis can be difficult due to verification bias, as not all patients with endometriosis undergo definitive diagnostic testing. The purpose of this State-of-the-Art Review is to provide a comprehensive update on the strengths and limitations of the diagnostic modalities used in endometriosis and discuss the relevance of diagnostic test accuracy research pertaining to each. We performed a comprehensive literature review of the following methods: clinical assessment including history and physical examination, biomarkers, diagnostic imaging, surgical diagnosis and histopathology. Our review suggests that, although non-invasive diagnostic methods, such as clinical assessment, ultrasound and magnetic resonance imaging, do not yet qualify formally as replacement tests for surgery in diagnosing all subtypes of endometriosis, they are likely to be appropriate for advanced stages of endometriosis. We also demonstrate in our review that all methods have strengths and limitations, leading to our conclusion that there should not be a single gold-standard diagnostic method for endometriosis, but rather, multiple accepted diagnostic methods appropriate for different circumstances.

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Section: Diagnosing Endometriosis: Presence or Absencementioning

confidence: 99%

Strengths and limitations of diagnostic tools for endometriosis and relevance in diagnostic test accuracy research

Pascoal

Wessels

Aas-Eng

et al. 2022

Ultrasound in Obstet & Gyne

View full text Add to dashboard Cite

show abstract

“…Endometriosis can now only be definitively diagnosed through histological evaluation of ectopic implants retrieved through invasive surgical or laparoscopic procedures [ 10 , 21 ], as the origin is unknown and there are discrepancies in its diagnosis and therapy [ 22 ]. The differential diagnosis of endometriosis may experience some issues if the final choice of the endometriotic implants is made only with the laparoscopic view [ 20 , 23 ]. The lesions may be mistaken for non-endometriotic lesions due to endometriosis’s variety of appearances [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs Dysregulation as Potential Biomarkers for Early Diagnosis of Endometriosis

et al. 2022

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Endometriosis is a benign chronic disease in women that is characterized by the presence of active foci of the endometrium or endometrial tissue occurring outside of the uterus. The disease causes disabling symptoms such as pelvic pain and infertility, which negatively affect a patient’s quality of life. In addition, endometriosis imposes an immense financial burden on the healthcare system. At present, laparoscopy is the gold standard for diagnosing the disease because other non-invasive diagnostic tests have less accuracy. In addition, other diagnostic tests have low accuracy. Therefore, there is an urgent need for the development of a highly sensitive, more specific, and non-invasive test for the early diagnosis of endometriosis. Numerous researchers have suggested miRNAs as potential biomarkers for endometriosis diagnosis due to their specificity and stability. However, the greatest prognostic force is the determination of several miRNAs, the expression of which varies in a given disease. Despite the identification of several miRNAs, the studies are investigatory in nature, and there is no consensus on them. In the present review, we first provide an introduction to the dysregulation of miRNAs in patients with endometriosis and the potential use of miRNAs as biomarkers in the detection of endometriosis. Then we will describe the role of the mir-200 family in endometriosis. Several studies have shown that the expression of the mir-200 family changes in endometriosis patients, suggesting that they could be used as a diagnostic biomarker and therapeutic target for endometriosis.

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Is Laparoscopic Visualization Sufficient for the Diagnosis of Endometriosis?

Cited by 2 publications

References 0 publications

Strengths and limitations of diagnostic tools for endometriosis and relevance in diagnostic test accuracy research

Strengths and limitations of diagnostic tools for endometriosis and relevance in diagnostic test accuracy research

MicroRNAs Dysregulation as Potential Biomarkers for Early Diagnosis of Endometriosis

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