Is littoral cell angioma of the spleen as rare as previously believed in the pediatric population?

Matuszczak, Ewa; Reszeć, Joanna; Dębek, Wojciech; Hermanowicz, Adam; Chyczewski, L

doi:10.5603/fhc.2012.0067

Cited by 9 publications

(3 citation statements)

References 24 publications

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“…The splenic involvement is distinguished by anastomosing monotonous vascular channels resembling splenic sinuses, but lined by tall endothelial cells with variable degrees of haemophagocytosis . The Ki67 index tends to be very low (<1%), as repeatedly described in previous reports …”

Section: Discussionsupporting

confidence: 62%

Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies

et al. 2016

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The cohort of 25 patients is the largest series of LCAs published to date. By using antibodies against recently introduced endothelial markers, we have expanded the immunoprofile of LCA. We have further highlighted the clinical significance of LCA, as more than half of the patients in this study also harboured a coexisting visceral malignancy. Therefore, we conclude that the finding of splenic LCA mandates a thorough clinical evaluation for a concomitant malignancy.

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Section: Discussionsupporting

confidence: 62%

Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies

et al. 2016

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“…However, there are 3 reported cases of solitary splenic nodules of LCA that were treated with tumor resection alone. 7,11,12 Unfortunately, long-term follow-up of these patients is unknown, considering 1 patient was managed for an indefinite time period, 1 was managed for only 3 months (both were without evidence of disease recurrence on imaging), 7,11 and the third report did not discuss follow-up. 12 In our case, isolated tumor resection was impossible because of the extent of disease.…”

Section: Discussionmentioning

confidence: 99%

A Novel Presentation of Littoral Cell Angioma and Lymphatic Malformations in a Neonate

et al. 2018

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This case report describes a novel presentation of littoral cell angioma (LCA) and lymphatic malformations involving the omentum and mesentery. To our knowledge, these 2 entities have not been reported in the same patient. A 1-month term infant male presented with chylous ascites. During his workup, imaging detected splenic nodules. Biopsies revealed that the nodules were LCA and the chylous ascites was secondary to microscopic mesenteric and omental lymphatic malformations. Evaluation for a secondary malignancy, an underlying immunologic defect, and genetic causes were unrevealing. The presence of LCA and lymphatic malformations in the same patient suggests a genetic link between these 2 rare vascular disorders and may help elucidate the etiopathogenesis of these 2 poorly understood anomalies.

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“…LCA may occur at any age without any sex-based predilection [7,8]. Occasional cases in children have also been reported [9,10].…”

Section: Discussionmentioning

confidence: 99%

Littoral cell angioma: A case report

Özkök¹,

Taşlı²,

Keçeci³

et al. 2014

MMJ

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We report the case of a 43-year-old male with a littoral cell angioma. Clinical examination of the spleen revealed multiple cystic masses surrounded by normal splenic tissue. Histopathologic and immunohistochemical findings confirmed the diagnosis of a littoral cell angioma. The rarity in the literature of littoral cell angiomas is striking.Key words: Littoral cell angioma, Spleen, Vascular tumor ÖZET Bu yazıda splenektomi materyelinde littoral hücreli anjiom tanısı olan 43 yaşında bir erkek hasta sunulmuştur. Hastanın klinik incelemesinde dalakta çok sayıda kistik kitleden oluşan lezyon saptanmıştır. Histopatolojik ve immunohistokimyasal bulgular littoral hücreli anjiom tanısını desteklemiştir. Lezyon son derece nadir olması nedeni ile tartışmaya değer bulunmuştur.

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Is littoral cell angioma of the spleen as rare as previously believed in the pediatric population?

Cited by 9 publications

References 24 publications

Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies

Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies

A Novel Presentation of Littoral Cell Angioma and Lymphatic Malformations in a Neonate

Littoral cell angioma: A case report

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