Is low level laser therapy or ozone therapy more effective for bone healing? Understanding the mechanisms of HIF-1α, RANKL and OPG

Alinca, Suzan Bayer; Sağlam, Ebru; Celik, Tugba Zengin; Hacısalihoğlu, Payam; Doğan, Mehmet Ali

doi:10.1080/10520295.2020.1743360

Cited by 7 publications

(6 citation statements)

References 44 publications

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“…Similar results have been reported for periodontal disease-induced bone destruction ( 92 , 93 ). Untreated periodontal pockets caused by the presence of anaerobic pathogens, vascular endothelial damage, edema and increased inflammatory cell infiltration, exhibit low oxygen levels ( 94 ).…”

Section: Biostimulation Of Dental and Periodontal Structuressupporting

confidence: 90%

Ozone therapy in dentistry: An overview of the biological mechanisms involved (Review)

Veneri,

Filippini,

Consolo

et al. 2024

Biomed Rep

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Section: Biostimulation Of Dental and Periodontal Structuressupporting

confidence: 90%

Ozone therapy in dentistry: An overview of the biological mechanisms involved (Review)

Veneri,

Filippini,

Consolo

et al. 2024

Biomed Rep

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“…Ele é produzido por um gerador de ozônio, dispositivo que capta o oxigênio e, através de uma onda elétrica, transforma a molécula de O2 em O3. Devido à grande instabilidade deste gás, ele é considerado um dos maiores agentes oxidantes do mundo e essa propriedade permite que o ozônio seja usado para diversos fins terapêuticos (Alinca et al, 2020). Somando ainda, este gás possui efeito analgésico, anti-inflamatório e aumenta a oxigenação tecidual, elevando a atividade funcional e o potencial de regeneração tecidual.…”

Section: Discussionunclassified

“…Embora a inflamação periodontal seja iniciada por componentes do biofilme subgengival, a produção e a liberação de agentes inflamatórios são gerados e controlados pelo hospedeiro. As respostas aos microrganismos são os principais responsáveis pela degradação periodontal (Alinca, Sağlam, Celik, Hacisalihoglu & Doğan, 2020).…”

Section: Introductionunclassified

Uso da ozonioterapia como tratamento adjuvante não cirúrgico para doenças periodontais: uma revisão integrativa da literatura

Matos

Castro

Gomes

2021

RSD

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O estudo ora conduzido tem como objetivo evidenciar os efeitos da terapia com ozônio como um tratamento integrativo e complementar não cirúrgico para doenças periodontais. Trata-se de uma revisão integrativa da literatura, na qual foram feitas buscas nas bases de dados Medline, Lilacs, EBSCOHost e Cochrane, utilizando os descritores “ozone”, “ozone therapy” e “periodontal disease” publicados entre 2011 e 2021, sendo eleitos 20 artigos para compor o estudo. O ozônio é um gás formado por três átomos de oxigênio e, devido à sua instabilidade, é considerado um dos maiores agentes oxidantes do mundo, o que permite que este gás seja usado para diversos fins terapêuticos. Esta substância possui importantes efeitos antimicrobianos contra bactérias gram-negativas, que desempenham um forte papel na etiologia das doenças periodontais. Somando-se, ainda, possui um amplo espectro de atividade, mas com baixa toxicidade e não causa resistência bacteriana. A ozonioterapia mostra-se como um eficiente tratamento integrativo e complementar à raspagem e alisamento radicular, que por vezes pode ser insuficiente no tratamento das doenças periodontais. Contudo, novos estudos devem ser realizados para avaliar e determinar os parâmetros clínicos do ozônio.

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“…33 In an animal study conducted on rats, LLLT had a more protective effect on bone destruction, when compared with ozone therapy. 34 With the aim of pain relief after orthodontic surgery, LLLT was effective, but ozone was not. 35 Considering these limited data, we decided to search any published comparative studies into ozone therapy versus LLLT.…”

Section: Introductionmentioning

confidence: 99%

A Comparison Between Low-Level Laser Therapy and Intra-articular Ozone Injection in Knee Osteoarthritis Treatment: A Randomized Clinical Trial

et al. 2021

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Introduction: Knee osteoarthritis (KOA) is a common degenerative joint disease, causing deformity, pain and a limited joint range of motion. Modification of the lifestyle and an exercise training program are the cornerstone of treatment. Alternative therapies such as laser or ozone are commonly used, but there is not any comparative study of low-level laser therapy (LLLT) versus ozone therapy. The aim of the study was to compare the efficacy and safety of the LLLT versus ozone in patients with KOA. Methods: In this single-blinded randomized clinical trial, 60 patients with KOA were assigned to LLLT or ozone groups (n=30). The First basic pain severity, the Western Ontario and McMaster Universities Arthritis Index (WOMAC) score and physical function were determined. Then in the LLLT group, the patients were provided with 12 sessions of LLLT. In the ozone group, 6 sessions of intra-articular injection of ozone were organized (in each session a mixture of 10 mL of bupivacaine 0.25% with 15 mL of ozone 30 μg/mL). In the middle and at the end of the intervention period, we reassessed the joint pain and physical function and the degree of improvement compared between the two groups. Results: In the middle and at the end of the treatment period in both groups, the joint pain decreased significantly. The same as pain, the self-administrated WOMAC score and the range of joint motion improved significantly in both groups. All of these variables exposed more improvement in the ozone group patients. Conclusion: The study showed that both LLLT and ozone are acceptable non-invasive methods in the non-surgical treatment of KOA. Compared to LLLT, the ozone was more effective. These methods must be considered in any patient who is not suitable for surgical interventions or does not experience enough improvement in symptoms following long periods of common exercise training programs.

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Is low level laser therapy or ozone therapy more effective for bone healing? Understanding the mechanisms of HIF-1α, RANKL and OPG

Cited by 7 publications

References 44 publications

Ozone therapy in dentistry: An overview of the biological mechanisms involved (Review)

Ozone therapy in dentistry: An overview of the biological mechanisms involved (Review)

Uso da ozonioterapia como tratamento adjuvante não cirúrgico para doenças periodontais: uma revisão integrativa da literatura

A Comparison Between Low-Level Laser Therapy and Intra-articular Ozone Injection in Knee Osteoarthritis Treatment: A Randomized Clinical Trial

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