Is methicillin-resistant Staphylococcus aureus a common pathogen in ventilation-associated pneumonia?

Abstract

Ventilator-associated pneumonia is a life threatening device related infection in intensive care units. Methicillin-resistant Staphylococcus aureus is considered a common contagious pathogen causing pneumonia and sepsis. To assess the prevalence of S aureus in comparison to other pathogens, and their antibacterial sensitivity profile in ventilator-associated pneumonia. Data regarding ventilator-associated pneumonia of adults admitted to the intensive care unit, at the Jordan University of Science and Technology Hospital, between 2012 and 2018 were extracted from the computerized system. Microorganisms and their susceptibility profiles were identified according to the Clinical and Laboratory Standards Institute. There were 547 isolates, of which 35 (6.4%) were Gram positive, 59% were methicillin resistant. Gram-negative isolates were present in 507 (92.6%) isolates, of which 82% were multidrug resistant, and 1% were Candida species. Gram-negative bacterial infections were significantly associated with ventilation usage. S aureus was not the predominant pathogen.

The impact of COVID-19 pandemic on healthcare associated infections: A teaching hospital experience

“…This is consistent with other reported studies. [15,25] On the other hand, an international retrospective study showed that gram-positive bacteria were the most common isolated microorganisms from COVID-19 patients. Streptococcus pneumonia and S aureus stood at 16.2% each.…”

Effects of low-frequency ultrasound combined with anti-MRSA agents on the mouse model of pulmonary infection

“…As a primary contributor to nosocomial pneumonia and healthcare-associated (HCA) pneumonia, methicillin-resistant Staphylococcus aureus (MRSA) is linked with significant morbidity and mortality ( 1 , 2 ). MRSA is responsible for 10%–40% of cases of HCA pneumonia, hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP) ( 3 ). MRSA pneumonia is characterized by a pronounced inflammatory reaction in the lungs, resulting in airway neutrophil influx, loss of alveolar structure, severe pulmonary edema, hemorrhage, and intrapulmonary bacterial proliferation.…”