Is monetary reward processing altered in drug-naïve youth with a behavioral addiction? Findings from internet gaming disorder

Yao, Yuan‐Wei; Liu, Lu; Worhunsky, Patrick D.; Lichenstein, Sarah; Ma, Shan-Shan; Zhu, Lei; Shi, Xinhui; Yang, Songshan; Zhang, Jintao; Yip, Sarah W.

doi:10.1016/j.nicl.2020.102202

Cited by 17 publications

(6 citation statements)

References 41 publications

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“…This may reflect that specifically the processing of Internet- or game-related stimuli is biased in IUD. In line with this explanation previous studies observed altered processing of internet related stimuli but not of general emotional or monetary reward related processing ( Starcke et al., 2018 ; Yao et al., 2020 ; Yu et al., 2021 ).…”

Section: Discussionsupporting

confidence: 71%

Opposing associations of Internet Use Disorder symptom domains with structural and functional organization of the striatum: A dimensional neuroimaging approach

Lei

et al. 2022

JBA

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BackgroundAccumulating evidence suggests brain structural and functional alterations in Internet Use Disorder (IUD). However, conclusions are strongly limited due to the retrospective case-control design of the studies, small samples, and the focus on general rather than symptom-specific approaches.MethodsWe here employed a dimensional multi-methodical MRI-neuroimaging design in a final sample of n = 203 subjects to examine associations between levels of IUD and its symptom-dimensions (loss of control/time management, craving/social problems) with brain structure, resting state and task-based (pain empathy, affective go/no-go) brain function.ResultsAlthough the present sample covered the entire range of IUD, including normal, problematic as well as pathological levels, general IUD symptom load was not associated with brain structural or functional alterations. However, the symptom-dimensions exhibited opposing associations with the intrinsic and structural organization of the brain, such that loss of control/time management exhibited negative associations with intrinsic striatal networks and hippocampal volume, while craving/social problems exhibited a positive association with intrinsic striatal networks and caudate volume.ConclusionsOur findings provided the first evidence for IUD symptom-domain specific associations with progressive alterations in the intrinsic structural and functional organization of the brain, particularly of striatal systems involved in reward, habitual and cognitive control processes.

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Section: Discussionsupporting

confidence: 71%

Opposing associations of Internet Use Disorder symptom domains with structural and functional organization of the striatum: A dimensional neuroimaging approach

Lei

et al. 2022

JBA

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“…In the corresponding HbR results, the horizontally symmetrical concentration pattern showing an increase in the IGD group and decrease in the CTRL group supports the results in the HbO response, indicating evidently weaker activation in the region. Based on previous research, we suggest that activation differences in the lateral OFC may reflect the low punishment sensitivity characteristic to individuals with addictive disorders including substance use disorder, pathological gambling, and IGD ( Fauth-Bühler & Mann, 2017 ; Jonker et al, 2014 ; Yao et al, 2020 ). Similar observations were made by Adinoff (2004) in participants with cocaine use disorder, suggesting that such results may imply difficulties in inhibitory control, while Volkow and Morales (2015) suggested that the disruption in addicted individuals’ lateral OFC may signify the inability to shift behaviors when no longer reinforced.…”

Section: Discussionmentioning

confidence: 82%

Prefrontal cortical activation in Internet Gaming Disorder Scale high scorers during actual real-time internet gaming: A preliminary study using fNIRS

Cho

Nah

Park

et al. 2022

JBA

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Background Observation of real-time neural characteristics during gameplay would provide distinct evidence for discriminating the currently controversial diagnosis of internet gaming disorder (IGD), and elucidate neural mechanisms that may be involved in addiction. We aimed to provide preliminary findings on possible neural features of IGD during real-time internet gaming using functional near-infrared spectroscopy (fNIRS). Methods Prefrontal cortical activations accompanying positive and negative in-game events were investigated. Positive events: (1) participant’s champion slays or assists in slaying an opponent without being slain. (2) the opposing team’s nexus is destroyed. Negative events: (1) participant’s champion is slain without slaying or assisting in slaying any opponent. (2) the team’s nexus is destroyed. Collected data were compared between the IGD group and control group, each with 15 participants. Results The IGD group scored significantly higher than the CTRL group on the craving scale. Following positive events, the IGD group displayed significantly stronger activation in the DLPFC. Following negative events, the IGD group displayed significantly weaker activation in the lateral OFC. Discussion and Conclusions Individuals scoring high on the IGD scale may crave for more internet gaming after encountering desired events during the game. Such observations are supported by the correlation between the craving scale and DLPFC activation. The IGD group may also show diminished punishment sensitivity to negative in-game experiences rendering them to continue playing the game. The present study provides preliminary evidence that IGD may demonstrate neural characteristics observed in other addictive disorders and suggests the use of fNIRS in behavioral addiction studies.

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“…This inconsistency may arise from a difference in samples: the previous study was based on participants with IGD. IGD can lead to functional and structural alterations of the brain that influence reward responsiveness, contributing to differences from the healthy population (107)(108)(109)(110). Since no studies have investigated the relationships between individual variables of BIS/BAS or impulsivity and components of PSU, the current study only provided preliminary insight into an issue certainly worth further study.…”

Section: Discussionmentioning

confidence: 99%

The roles of behavioral inhibition/activation systems and impulsivity in problematic smartphone use: A network analysis

Guo

Yang

et al. 2022

Front. Public Health

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BackgroundBehavioral inhibition/activation systems (BIS/BAS) and impulsivity are associated with problematic smartphone use (PSU). However, no studies to date have explored how the subdomains of BIS/BAS and the dimensions of impulsivity relate to the components of PSU in a joint framework. This study aimed to examine the relationships between the three constructs at a fine-grained level and identify the central nodes and bridge nodes of their relationships using network analysis.MethodsA regularized partial correlation network of PSU, BIS/BAS, and impulsivity communities was estimated to investigate the connections between variables and determine the expected influence and bridge expected influence for each variable based on data from 325 Chinese adults. PSU, BIS/BAS, and impulsivity were assessed using the Smartphone Application-Based Addiction Scale (SABAS), BIS/BAS scales, and Barratt Impulsiveness Scale-Version 11 (BIS-11), respectively.ResultsIn addition to connections within each community, network analysis revealed that there were connections between different communities, especially connections to PSU. I2 “motor impulsivity” was strongly associated with PSU2 “conflict” and PSU6 “relapse”; BASR “BAS-reward responsiveness” was strongly associated with PSU5 “withdrawal.” Nodes BASR “BAS-reward responsiveness” and PSU6 “relapse” were the most central variables, while nodes BASR “BAS-reward responsiveness” and I2 “motor impulsivity” were the strongest bridge variables.ConclusionThe connections between the subdomains of BIS/BAS and the components of PSU and between the dimensions of impulsivity and the components of PSU may be particularly important in the development and maintenance of PSU. The central variables identified here, along with the bridge variables, could be promising and effective targets for the prevention and intervention of PSU.

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Is monetary reward processing altered in drug-naïve youth with a behavioral addiction? Findings from internet gaming disorder

Cited by 17 publications

References 41 publications

Opposing associations of Internet Use Disorder symptom domains with structural and functional organization of the striatum: A dimensional neuroimaging approach

Opposing associations of Internet Use Disorder symptom domains with structural and functional organization of the striatum: A dimensional neuroimaging approach

Prefrontal cortical activation in Internet Gaming Disorder Scale high scorers during actual real-time internet gaming: A preliminary study using fNIRS

The roles of behavioral inhibition/activation systems and impulsivity in problematic smartphone use: A network analysis

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