Is Mycobacterium tuberculosis carcinogenic to humans?

Roy, Deodutta; Ehtesham, Nasreen Z.; Hasnain, Seyed E.

doi:10.1096/fj.202001581rr

Cited by 7 publications

(4 citation statements)

References 178 publications

(498 reference statements)

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“…All complications may increase the risk of secondary lung cancer compared with the non-tuberculosis cohort in primary cancer. Some even believe that Mtb is an absolute lung carcinogen, Mtb acts as an initiator and promoter of tumor growth [ 103 ]. As a result, clinicians should consider this in patients with TB infection, because in patients with primary cancer, TB is more likely to cause secondary lung cancer [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

The relationship between previous pulmonary tuberculosis and risk of lung cancer in the future

Qin

Chen

et al. 2022

Infect Agents Cancer

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Various investigations have expanded the views that tuberculosis is an important risk factor for lung cancer occurrence. Lung cancer originates from chronic inflammation and infection. It is becoming clearer that Mycobacterium tuberculosis (M.tb) in tuberculosis patients meticulously schemes multiple mechanisms to induce tumor formation and is indispensable to participate in the occurrence of lung cancer. In addition, some additional factors such as age, sex and smoking, accelerate the development of lung cancer after Mycobacterium tuberculosis infection. The clarification of these insights is fostering new diagnoses and therapeutic approaches to prevention of the patients developing from tuberculosis into lung cancer.

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Section: Discussionmentioning

confidence: 99%

The relationship between previous pulmonary tuberculosis and risk of lung cancer in the future

Qin

Chen

et al. 2022

Infect Agents Cancer

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“…Epidemiological research has shown that patients with TB have an increased risk of being diagnosed with pulmonary cancers with almost a two-fold increase in the risk of lung cancer ( Shiels et al., 2011 ; Luczynski et al., 2022 ). Previous in vitro studies suggested that M.tb has the potential to promote cancerous processes and in the animal model, chronic tuberculosis infection could induce lung cancer in mice ( Roy et al., 2021 ). Several mechanisms may be involved in this process including increased production of inflammatory cytokines which can target anti-apoptotic intracellular signaling pathways in the tumor cells.…”

Section: Potential Roles Of Evs In the Promotion Of Tuberculosis Towa...mentioning

confidence: 99%

Significance of extracellular vesicles in orchestration of immune responses in Mycobacterium tuberculosis infection

Alipoor,

Elieh-Ali-Komi

2024

Front. Cell. Infect. Microbiol.

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Mycobacterium tuberculosis (M.tb), the causative agent of Tuberculosis, is an intracellular bacterium well known for its ability to subvert host energy and metabolic pathways to maintain its intracellular survival. For this purpose, the bacteria utilize various mechanisms of which extracellular vehicles (EVs) related mechanisms attracted more attention. EVs are nanosized particles that are released by almost all cell types containing active biomolecules from the cell of origin and can target bioactive pathways in the recipient cells upon uptake. It is hypothesized that M.tb dictates the processes of host EV biogenesis pathways, selectively incorporating its molecules into the host EV to direct immune responses in its favor. During infection with Mtb, both mycobacteria and host cells release EVs. The composition of these EVs varies over time, influenced by the physiological and nutritional state of the host environment. Additionally, different EV populations contribute differently to the pathogenesis of disease at various stages of illness participating in a complex interplay between host cells and pathogens. These interactions ultimately influence immune responses and disease outcomes. However, the precise mechanisms and roles of EVs in pathogenicity and disease outcomes remain to be fully elucidated. In this review, we explored the properties and function of EVs in the context of M.tb infection within the host microenvironment and discussed their capacity as a novel therapeutic strategy to combat tuberculosis.

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“…Given the association between M. tuberculosis and tuberculosis (TB), a substantial volume of literature has arisen regarding the molecular mechanisms underlying this disease, including its possible involvement in carcinogenesis. The Mycobacterium oncogenic hypothesis has garnered increasing attention in recent years [159][160][161]. These studies delve into the intuitive association between TB and lung cancer, drawing on numerous epidemiological investigations that suggest a possible link between M. tuberculosis infection and various malignant tumors, particularly lung cancer.…”

Section: Mycobacteria and Cancer: Focus On Breast Cancermentioning

confidence: 99%

Drinking Water Microbiota, Entero-Mammary Pathways and Breast Cancer: Focus on Nontuberculous Mycobacteria

Maranha,

Alarico,

Nunes-Costa

et al. 2024

Preprint

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The prospect of drinking water serving as a conduit for gut bacteria, artificially selected by disinfection strategies and lack of monitoring at the point of use, is concerning. Certain opportunistic pathogens, notably some nontuberculous mycobacteria (NTM), often exceed coliform bacteria levels in drinking water, posing safety risks. NTM and other microbiota resist chlorination and thrive in plumbing systems. When inhaled, opportunistic NTM can infect the lungs of immunocompromised or chronically ill patients, and the elderly, primarily postmenopausal women. When ingested with drinking water, NTM often survive stomach acidity, reach the intestines, migrate to other organs using immune cells as vehicles, potentially colonizing tumor tissue, including in breast cancer. The link between the microbiome and cancer is not new, yet the recognition of intratumoral microbiomes is a recent development. Breast cancer risk rises with age, and NTM infections emerged as a concern among breast cancer patients. In addition to studies hinting at a potential association between chronic NTM infections and lung cancer, NTM have also been detected in breast tumors at levels higher than normal adjacent tissue. Evaluating the risks of continued ingestion of contaminated drinking water is paramount, especially given the ability of various bacteria to migrate from the gut to breast tissue via entero-mammary pathways. This underscores a pressing need to revise water safety monitoring guidelines and delve into hormonal factors, which includes addressing the disproportionate impact of NTM infections and breast cancer on women and examining the potential health risks posed by the cryptic and unchecked microbiota from drinking water.

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Is Mycobacterium tuberculosis carcinogenic to humans?

Cited by 7 publications

References 178 publications

The relationship between previous pulmonary tuberculosis and risk of lung cancer in the future

The relationship between previous pulmonary tuberculosis and risk of lung cancer in the future

Significance of extracellular vesicles in orchestration of immune responses in Mycobacterium tuberculosis infection

Drinking Water Microbiota, Entero-Mammary Pathways and Breast Cancer: Focus on Nontuberculous Mycobacteria

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