Is needle biopsy of the liver necessary to diagnose HCC ? Reply

Cetta, Francesco; Zuckermann, Michele; Nisi, Angela

doi:10.1136/gut.48.3.440

Cited by 6 publications

(5 citation statements)

References 5 publications

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“…The adverse consequences of tumour seeding after percutaneous biopsy are well recognized; 20 per cent of patients have developed seeding along the biopsy track in some series151–154. There are only two reports of tumour seeding following ILT, making this an extremely rare complication of this procedure24.…”

Section: Clinical Outcomesmentioning

confidence: 99%

Rearrangement of a (Dithiolato)platinum(II) Complex Formed by Reaction of Cyclic Disulfide 7,8‐Dithiabicyclo[4.2.1]nona‐2,4‐diene with a Platinum(0) Complex: Oxidation of the Rearranged (Dithiolato)platinum(II) Complex

Ishii

Kashiura

Hayashi

et al. 2007

Chemistry A European J

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Reaction of the title bicyclic disulfide 16 with [(Ph3P)2Pt(eta2-C2H4)] (2) yielded the corresponding (dithiolato)platinum(II) complex 17 by oxidative addition. The initial product 17 isomerized at room temperature in a [1,5]-sulfur rearrangement to give another (dithiolato)platinum(II) complex 18 in high isolated yield. Oxidation reactions of 18 with dimethyldioxirane (DMD) provided (sulfenato-thiolato)platinum(II) 23, (sulfinato-thiolato)platinum(II) 24, (sulfenato-sulfinato)platinum(II) 25, and (disulfinato)platinum(II) 26 complexes, the structures of which were elucidated by NMR spectroscopy and X-ray crystallography. The oxidation process took place regioselectively in the first step and chemoselectively in the second. The selectivities are discussed.

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Section: Clinical Outcomesmentioning

confidence: 99%

Rearrangement of a (Dithiolato)platinum(II) Complex Formed by Reaction of Cyclic Disulfide 7,8‐Dithiabicyclo[4.2.1]nona‐2,4‐diene with a Platinum(0) Complex: Oxidation of the Rearranged (Dithiolato)platinum(II) Complex

Ishii

Kashiura

Hayashi

et al. 2007

Chemistry A European J

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“…Cependant, dans les pays développés où le dépistage du carcinome hépatocellulaire est précoce, des cas d'essaimage tumoral sur le trajet de ponction ont été rapportés [16][17][18][19]. Aussi, sommes-nous du même avis que Cetta et al [20] que la PBH est indiquée pour faire le diagnostic de carcinome hépatocellulaire uniquement dans les cas où l'alphafoetoprotéine, l'échographie et le scanner ne sont pas possibles.…”

Section: Complicationsunclassified

Ponction-biopsie hépatique en ambulatoire: indications, méthodes et complications. Évaluation prospective de 106 patients au centre hospitalier universitaire Yalgado-Ouédraogo de Ouagadougou

Sombié

Bougouma

Diallo

et al. 2009

J Afr Hepato Gastroenterol

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“…In unresectable malignant lesions, a precise cytohistologic typing is crucial for appropriate alternative therapy. The need for biopsy diagnosis in HCC is now a hotly debated topic [2,4,12]. The stand in some practices is that a needle biopsy may be indicated only if it is not possible to diagnose HCC by other means, namely, serum AFP concentration, spiral computed tomography (CT) and magnetic resonance imaging (MRI).…”

Section: Current Diagnostic Issuesmentioning

confidence: 99%

“…Needle track seeding by malignant cells is the main reason often cited by opponents of FNAB of the liver [2,62-64]. There is no reliable data to establish the risk; the figure of 0.006% is regarded as a gross underestimation by many authors [3,65,66].…”

Section: Current Diagnostic Issuesmentioning

confidence: 99%

Fine needle aspiration biopsy of the liver : Algorithmic approach and current issues in the diagnosis of hepatocellular carcinoma

Wee

2005

CytoJournal

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The role of fine needle aspiration biopsy (FNAB) in the evaluation of focal liver lesions has evolved. Guided FNAB is still useful to procure a tissue diagnosis if clinical, biochemical and radiologic findings are inconclusive. Major diagnostic issues include: (i) Distinction of benign hepatocellular nodular lesions from reactive hepatocytes, (ii) Distinction of well-differentiated hepatocellular carcinoma (WD-HCC) from benign hepatocellular nodular lesions, (iii) Distinction of poorly differentiated HCC from cholangiocarcinoma and metastatic carcinomas, (iv) Determination of histogenesis of malignant tumor, and (v) Determination of primary site of origin of malignant tumor. This review gives a general overview of hepatic FNAB; outlines an algorithmic approach to cytodiagnosis with emphasis on HCC, its variants and their mimics; and addresses current diagnostic issues. Close radiologic surveillance of high-risk cirrhotic patients has resulted in the increasing detection of smaller lesions with many subjected to biopsy for tissue characterization. The need for tissue confirmation in clinically obvious HCC is questioned due to risk of malignant seeding. When a biopsy is indicated, core needle biopsy is favored over FNAB. The inherent difficulty of distinguishing small/early HCC from benign hepatocellular nodular lesions has resulted in indeterminate reports. Changing concepts in the understanding of the biological behavior and morphologic evolution of HCC and its precursors; and the current lack of agreement on the morphologic criteria for distinguishing high-grade dysplastic lesions (with small cell change) from WD-HCC, have profound impact on nomenclature, cytohistologic interpretation and management. Optimization of hepatic FNAB to enhance the yield and accuracy of diagnoses requires close clinicopathologic correlation; combined cytohistologic approach; judicious use of ancillary tests; and skilled healthcare teams.

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Is needle biopsy of the liver necessary to diagnose HCC ? Reply

Cited by 6 publications

References 5 publications

Rearrangement of a (Dithiolato)platinum(II) Complex Formed by Reaction of Cyclic Disulfide 7,8‐Dithiabicyclo[4.2.1]nona‐2,4‐diene with a Platinum(0) Complex: Oxidation of the Rearranged (Dithiolato)platinum(II) Complex

Rearrangement of a (Dithiolato)platinum(II) Complex Formed by Reaction of Cyclic Disulfide 7,8‐Dithiabicyclo[4.2.1]nona‐2,4‐diene with a Platinum(0) Complex: Oxidation of the Rearranged (Dithiolato)platinum(II) Complex

Ponction-biopsie hépatique en ambulatoire: indications, méthodes et complications. Évaluation prospective de 106 patients au centre hospitalier universitaire Yalgado-Ouédraogo de Ouagadougou

Fine needle aspiration biopsy of the liver : Algorithmic approach and current issues in the diagnosis of hepatocellular carcinoma

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