Is obesity an inflammatory disease?

Ramos, Eduardo J.B.; Xu, Yuan; Романова, И. В.; Middleton, Frank A.; Chen, Chung; Quinn, Robert H.; Inui, Akio; Das, Undurti N.; Meguid, Michael M.

doi:10.1067/msy.2003.267

Cited by 144 publications

(75 citation statements)

References 11 publications

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“…Rats had free access to diet and municipal tap water. 34,36,37,42,43 To induce obesity, rats were fed a high-energy diet (D12266, Research Diets, New Brunswick, NJ) for 16 weeks. 34 The highenergy diet consisted of 4.5 kcal/g (of which, 21% of the metabolizable energy content was protein, 31% fat, and 48% carbohydrate, consisting 50% sucrose).…”

Section: Rats Study Conditions Diet-induced Obesitymentioning

confidence: 99%

Sustained Weight Loss After Roux-en-Y Gastric Bypass Is Characterized by Down Regulation of Endocannabinoids and Mitochondrial Function

Guijarro

Osei‐Hyiaman²,

Harvey−White³

et al. 2008

Annals of Surgery

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Objective-To determine the physiologic importance of endocannabinoids and mitochondrial function in the long-term outcome using a rat model of Roux-en-Y gastric bypass (RYGB) surgery.Background-Sixteen million people are morbidly obese and RYGB surgery is the most effective treatment. Endocannabinoids are implicated in appetite stimulation and regulation of peripheral energy metabolism. We hypothesize that down-regulation of endocannabinoids and alterations in mitochondrial function and hormones favoring catabolism contribute to sustained RYGB-induced weight loss.

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Section: Rats Study Conditions Diet-induced Obesitymentioning

confidence: 99%

Sustained Weight Loss After Roux-en-Y Gastric Bypass Is Characterized by Down Regulation of Endocannabinoids and Mitochondrial Function

Guijarro

Osei‐Hyiaman²,

Harvey−White³

et al. 2008

Annals of Surgery

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“…33 In fact, adipocytes secrete several cytokines known to contribute to an obesity-associated inflammatory state. 34,35 This chronic inflammatory state may predispose to cancer etiopathogenesis, through adipokines roles that help to explain the molecular basis of obesity-associated PCa.…”

Section: Obesity and Pcamentioning

confidence: 99%

The link between obesity and prostate cancer: the leptin pathway and therapeutic perspectives

Ribeiro

Lopes

Medeiros

2005

Prostate Cancer Prostatic Dis

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Obesity-associated prostate cancer (PCa) remains controversial, although most studies rely on body mass index evaluation, which is an indirect measure of fatness. Studies using body fat measurement and disease stratification according to PCa stage found stronger associations between obesity and PCa. Leptin is a pleiotrophic hormone mainly synthesized by adipocytes that acts in peripheral organs such as the prostate. This article reviews obesity-associated leptin's pathophysiological role in PCa progression. PCa development results from some known risk factors. Currently, there is enough evidence suggesting that leptin is an additional factor involved in advanced PCa occurrence, and obesity association with high-grade disease. Life-long exposure to genetic and/or environmental susceptibility factors that predispose to obesity and higher leptin levels may increase the risk for advanced PCa.

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“…20 Generally, the more built up of adipose tissue is linked with increased in the production of pro-inflammatory molecules, likewise, decreased adiposity is related to a reduction in the level of pro-inflammatory as well as an increase in the concentration of anti-inflammatory molecules, thereby obesity is now presumed as a proinflammatory state. 16,23 The considerable association between obesity both with inflammation and cardiovascular disease, similarly, change in body composition seen in patients with RA heralds the study of obesity in patients with RA highly significant. Based on what is described regarding potential association between obesity and activation of pro-inflammatory pathways, one should conclude that obese RA patients have presumably a more severe and active disease.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of obesity in rheumatoid arthritis and its association with disease activity and latex positivity in a sample of patients in Erbil

Younis¹,

Al-Bustany²

2017

ZJMS

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Methods: One hundred twenty patients with rheumatoid arthritis who were regularly visiting Rizgary Teaching Hospital in Erbil were included in a cross-sectional study using specially designed mixed questionnaire. Body mass index and waist circumferences were measured, and their association with disease activity score 28 (DAS28) and clinical disease activity index (CDAI) were estimated. Furthermore, we evaluated their association with positive latex test. Results: There was increased frequency of obesity in rheumatoid arthritis patients, and there was a positive association between body mass index and waist circumference with disease activity measured by DAS28 and CDAI (P <0.001). There was no significant association between obesity and latex positivity which has been assessed separately for males and females (P = 0.898 and 0.086, respectively). Conclusion: Obesity is frequently found in rheumatoid arthritis patients. It is associated with higher disease activity, but not with the latex positivity in these patients.

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Is obesity an inflammatory disease?

Cited by 144 publications

References 11 publications

Sustained Weight Loss After Roux-en-Y Gastric Bypass Is Characterized by Down Regulation of Endocannabinoids and Mitochondrial Function

Sustained Weight Loss After Roux-en-Y Gastric Bypass Is Characterized by Down Regulation of Endocannabinoids and Mitochondrial Function

The link between obesity and prostate cancer: the leptin pathway and therapeutic perspectives

Prevalence of obesity in rheumatoid arthritis and its association with disease activity and latex positivity in a sample of patients in Erbil

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