Is Obstructive Sleep Apnea Associated With Greater Thoracic Aortic Size?

Meuleman, Catherine; Boccara, Franck; Éderhy, Stéphane; Dufaitre, Ghislaine; Fleury, Bernard; Cohen, Ariel

doi:10.1016/j.jacc.2008.10.052

Cited by 3 publications

(2 citation statements)

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“…In an early cross-sectional study in 76 patients with OSA, Meuleman et al found that aortic root diameter ranged from 26.9 to 44.6 mm with a mean (±SD) of 35.3 ± 3.8 mm, and only 3 (3.9%) patients had aortic root dilation. 20 The investigators of the study concluded that the prevalence of aortic root enlargement was not increased in OSA 21 and reiterated in a published correspondence 22 on a research letter 23 that they did not find any correlation of aortic root diameter with AHI or time spent with oxygen desaturation less than 90%. 24 In the latter study in 150 consecutive patients who were referred for confirmation of OSA, thoracic aortic diameter measured with a chest CT was significantly greater in 110 patients with OSA than 40 patients without OSA ( n = 36.8 ± 3.6 mm vs. 31.5 ± 4.5 mm, P < 0.001).…”

Section: Discussionmentioning

confidence: 96%

“…Finally, our study participants had relatively smaller body mass index and lower prevalence of obesity than European and US patients with OSA. 23 The prevalence of obesity is increasing in China, but still relatively low. Indeed, according to the recent China nationwide blood pressure survey in 451,755 adults, mean body mass index was 23.8 kg/m² and 12.1% had a body mass index of ≥28 kg/m².…”

Section: Discussionmentioning

confidence: 99%

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Aortic Root Diameter in Hypertensive Patients With Various Stages of Obstructive Sleep Apnea

Wang

Kang

et al. 2021

American Journal of Hypertension

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Background Obstructive sleep apnea (OSA) is a risk factor of several cardiovascular diseases. We investigated the association between aortic root diameter and hypoxia-related parameters in hypertensive patients with OSA. Methods Our study included 242 hypertensive patients with OSA (52 mild, 71 moderate and 119 severe). All the patients underwent echocardiography for measuring aortic root diameter and polysomnography for measuring apnea-hyponea index (AHI), oxygen desaturation index and time spent with oxygen desaturation less than 90%. Results The study patients included 19.8% women and had a mean (±SD) age of 49.9±12.9 years, a mean aortic root diameter of 33.4±2.6 mm and a prevalence of echocardiographic aortic root dilation of 3.7%. Patients with mild, moderate and severe OSA had similar echocardiographic left ventricular structure. However, patients with severe OSA had a significantly (P<0.05) greater aortic root diameter (33.9±2.4 mm vs 32.4±2.2 and 33.4±2.9 mm, respectively) and higher prevalence of aortic root dilatation (5% vs 1% and 3%, respectively) than those with mild and moderate OSA. Aortic root diameter corrected by body height was significantly (P<0.001) associated with AHI, oxygen desaturation index and time spent with oxygen desaturation less than 90% (r=0.23 to 0.33). After adjustment for various confounding factors, the associations between aortic root diameter and polysomnography parameters remained statistically significant (P<0.05). Conclusions The severity of OSA was associated with the aortic root diameter. Patients with severe OSA had a greater aortic root diameter.

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