Is photodynamic therapy a viable antiviral weapon against COVID-19 in dentistry?

Subramanian

et al. 2021

JPRI

Introduction: Solanum virginianum commonly known as wild eggplant or nightshade plant, is a prickly herb found in most of the parts of Asia and Australia of the world. It is used by the local people as folk medicines in treating throat infections and other inflammatory problems. Various phytoconstituents have been found, the major constituent is alkaloid. It has a vital role in various traditional as well as medicinal uses for curing internal and external physiological disorders. To determine the evaluation of anti proliferation potential of Solanum virginianum human hepatocellular carcinoma cell line. Materials and Methods: The effect of solanum virginianum hepG2 cell viability was measured by MTT assay. Briefly, the cells (1 × 104 cells per mL) were seeded in a 96 well microtiter plate (100 per well) with replications. Treatment was conducted for 24 hr with different concentrations (50, 100, 150, 200, 250, 300 μM) of solanum virginianum. Cell morphological changes were observed in phase contrast microscopy. Results: Cells were treated with solanum virginianum at higher concentration (50, 75, 100, 200, 300 and 400 μM) for 24 h, and cell viability was evaluated by MTT assay. Data are shown as means ± SD (n = 3). * compared with the control-blank group, p < 0.001. Conclusion: From the results, the extracts were cytotoxic to the hepG2 cells at (60μg/mL) concentration and incubation period. However more research is needed to understand the mechanisms of cytotoxicity of the plants.

Section: Resultsmentioning

confidence: 99%

“…Briefly, the cells (1 × 10 4 cells per mL) were seeded in a 96 well microtiter plate (100 per well) with replications. Treatment was conducted for 24 hr with different concentrations (50, Original Research Article 100, 150, 200, 250, 300 μM) of solanum virginianum. Cell morphological changes were observed in phase contrast microscopy.…”

mentioning

confidence: 99%

Evaluation of Anti Proliferative Potential of Solanum virginianum Human Hepatocellular Carcinoma Cell Line

Selvapriya

Subramanian

et al. 2021

JPRI

“…Mouthwash is expected to show profitable growth in the coming years because of the growing professional recognition of biofilm disorganization, and their increasing use by consumers linked to oral quality of life [21]. Our team has extensive knowledge and research experience that has translate into high quality publications [22][23][24][25][26][27][28][29][30][31][32][33][34]26,[35][36][37][38][39][40][41]. Although a lot of studies have been done on Titanium dioxide nanoparticles and its various activities like antiinflammatory [42], antioxidant and anti diabetic [43,44,45], there are not many studies in the area of checking anti inflammatory and antioxidant activity of titanium dioxide nanoparticles synthesised using Mucuna pruriens, thus the present study aims to assess the antioxidant activity and anti inflammatory activity of titanium dioxide nanoparticles synthesised using Mucuna pruriens.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antiinflammatory Activity of Titanium Dioxide Nanoparticles Synthesised Using Mucuna pruriens

Aditya

Rajeshkumar

et al. 2021

JPRI

Introduction: The genus Mucuna, belonging to the Fabaceae family, sub family Papilionaceae, includes approximately 150 species of annual and perennial legumes. Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide in large quantities for use in a wide range of applications.Various studies have been done in this topic like determining the efficacies of antibacterial and antioxidant activities of aqueous leaf extract of Psidium guajava mediated biosynthesis of titanium dioxide nanoparticles. Other studies have suggested that Obtaining biopeptides by enzymatic hydrolysis adds value to proteins of vegetative origin, such as Mucuna pruriens L. Thus it evaluated the effect of enzymatic digestion of protein derivatives obtained from M. pruriens L. Although a lot of studies have been done on Titanium dioxide nanoparticles and its various activities like anti-inflammatory, antioxidant and anti diabetic, there are not many studies in the area of checking anti inflammatory and antioxidant activity of titanium dioxide nanoparticles synthesised using Mucuna pruriens The aim of this study is to observe the antioxidant and anti inflammatory activity of Titanium dioxide nanoparticles synthesised using Mucuna pruriens. Materials and Methods: A titanium dioxide nanoparticle is synthesised using Mucuna pruriens, extract used to perform albumin denaturation assays and DPPH method, where % zone of inhibition increases as the concentration of nanoparticles increases. Results: The Mucuna pruriens medicated titanium dioxide nanoparticle has positive antioxidant and anti-inflammatory properties. Conclusion: The present study concluded that Mucuna pruriens mediated copper nanoparticle has good antioxidant and anti-inflammatory activity at its high concentration which is nearer to that of the standard drugs.

“…There is no previous report on free radical scavenging activity. Our team has extensive knowledge and research experience that has translate into high quality publications [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The present study aims to evaluate the free radical Scavenging activity of Pterocarpus santalinus ethanolic extract preparation.…”

Section: Introductionmentioning

confidence: 99%

Pterocarpus santalinus Ethanolic Extract Preparation and Its Free Radical Scavenging Activity

Sri

Rajeshkumar

et al. 2021

JPRI

Introduction: Pterocarpus santalinus commonly known as Red sanders, is a member of the Fabaceae family. It is endemic to India and is classified as internationally endangered, with illegal harvesting posing a significant concern. The plant is known for its distinctive wood, which has great colour, beauty, and technical features. The red wood produces santalin, a natural dye that is used to colour pharmaceuticals and foodstuffs. The decoction made from the heartwood is said to have a variety of therapeutic characteristics in traditional medicine. It's been used to induce vomiting as well as treat eye illnesses, mental disorders, and ulcers. Aim: This study aimed to find the free radical scavenging activity of Pterocarpus santalinus ethanolic extract preparation. Materials and Methods: DPPH and H202 Assay was used to test the antioxidant activity of plant extract. Pterocarpus santalinus were purchased commercially from an herbal health centre,in Chennai. The obtained powder Pterocarpus santalinus stored in an airtight container. 5 gram of powder is mixed with 50 ml of ethanol and kept in the orbital shaker for 72 hours, after it has boiled in a heating mantle at 62-70℃ for 5-10 min. The extract is filtered using whatman filter paper 1.The filter extract again contracted using heating mantle. Results: The extract shows very good antioxidant activity for the P.santalinus extract by using DPPH and H202 Assay. Conclusion: The free radical scavenging activity of Pterocarpus santalinus ethanolic extract preparation was effective.