Is polycystic ovarian morphology related to a poor oocyte quality after controlled ovarian hyperstimulation for intracytoplasmic sperm injection? Results from a prospective, comparative study

Sigala, Julien; Sifer, C.; Dewailly, Didier; Robin, Geoffroy; Bruyneel, Aude; Ramdane, Nassima; Lefebvre‐Khalil, V.; Mitchell, Valérie; Decanter, Christine

doi:10.1016/j.fertnstert.2014.09.040

Cited by 43 publications

(36 citation statements)

References 37 publications

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“…Despite the changing effects of androgens and PCO morphology among groups, the end point is similar in terms of biochemical, clinical, and ongoing pregnancy rates. A recently published study on the effect of PCO morphology on oocyte quality in intracytoplasmic sperm injection cycles compared with a control group showed neither positive nor negative effects and the MII oocyte number was found to be higher in the group with PCO morphology, whereas the ratio of MII oocyte was similar, the number of top quality embryos was comparable between groups but the implantation and clinical pregnancy rates were found significantly higher in the PCO morphology group ( 19 ) . The authors tried to assess the effect of PCO morphology alone on oocyte quality so their results were not consistent with ours because of the ignored effect of hyperandrogenemia, which was shown to have a favorable effect in our study.…”

Section: Discussionmentioning

confidence: 77%

Characteristics and outcomes of in vitro fertilization in different phenotypes of polycystic ovary syndrome

Selçuk

Özkaya

Eser

et al. 2016

tjod

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Objective:The aim of this study was to investigate whether polycystic ovary syndrome (PCOS) phenotype without polycystic ovaries (PCO) differs in terms of in vitro fertilization (IVF) outcomes compared with classic phenotypes.Materials and Methods:This retrospective controlled study included 262 patients who underwent IVF treatment with an indication of unexplained or tubal factor infertility (control group), ovulatory patients with PCO morphology (group 1), PCOS phenotype with oligoanovulation and hyperandrogenemia (group 2), PCOS phenotype with PCO morphology and oligoanovulation (group 3). Outcomes and baseline characteristics of IVF-embryo transfer treatments were compared among all groups.Results:PCOS phenotype without PCO morphology had similar IVF stimulation characteristics compared with classic phenotypes; however, a higher total gonadotropin dose was needed to achieve similar results compared with patients with PCO morphology with or without PCOS. Basal follicle-stimulating hormone level (beta coefficient=0.207, p=0.003), group (beta coefficient=-0.305, p<0.001) and age (beta coefficient=0.311, p<0.001) were significantly associated with the total gonadotropin dose. The number of good quality embryo on transfer day was significantly lower in patients with isolated PCO morphology and PCO morphology with oligoanovulation than in those with PCOS phenotype without PCO morphology.Conclusion:PCO morphology provides easier stimulation, whereas hyperandrogenemia provides better results as good quality embryos. However, the end point is similar in terms of biochemical, clinical, and ongoing pregnancy rates.

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Section: Discussionmentioning

confidence: 77%

Characteristics and outcomes of in vitro fertilization in different phenotypes of polycystic ovary syndrome

Selçuk

Özkaya

Eser

et al. 2016

tjod

View full text Add to dashboard Cite

show abstract

“…It has previously been asserted that patients with PCOS have poor‐quality embryos and experience lower implantation rates [1]. However, a more recent study has demonstrated that the percentage of embryos that are of high quality on day three of in vitro fertilization/ICSI was similar between patients with PCOS and an age‐matched control group [19]. Among patients with PCOS, increased oocyte yields could contribute to the availability of more fertilized oocytes and good‐quality embryos; this could be associated with an enhanced implantation rate.…”

Section: Discussionmentioning

confidence: 97%

Effects of previous ovarian drilling on cumulative ongoing pregnancy rates among patients with polycystic ovarian syndrome undergoing in vitro fertilization

Cai

Liu

Sun

et al. 2016

Intl J Gynecology & Obste

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“…Understandably as PCOS is believed to be associated with poor oocyte and subsequent embryo quality, [82][83][84] it is expected that fertility may be impaired in a woman with PCOS. However, this subfertility is compounded by an altered endometrial environment which may lead to the noted increased risk of miscarriage and adverse pregnancy outcome in women with PCOS.…”

Section: Neonatal Outcomesmentioning

confidence: 99%

Polycystic Ovary Syndrome, Obesity, and Pregnancy

2016

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to one in five reproductive-aged women. It is underpinned by insulin resistance and hyperandrogenism and is associated with metabolic, reproductive, and psychological features. Women with PCOS have higher rates of obesity and central adiposity compared with women without PCOS, and weight strongly influences prevalence and clinical severity of PCOS. Women with PCOS may have subfertility and women should be aware of factors affecting fertility, in particular the impact of obesity and age. Once pregnant, women with PCOS have significantly increased risk of pregnancy-related complications including gestational diabetes, hypertensive disorders, premature delivery, and delivery by cesarean section. The offspring of women with PCOS may have increased risk of congenital abnormalities and hospitalization in childhood. Clinicians should be aware of the increased risk and screen, prevent, and manage accordingly.

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Is polycystic ovarian morphology related to a poor oocyte quality after controlled ovarian hyperstimulation for intracytoplasmic sperm injection? Results from a prospective, comparative study

Cited by 43 publications

References 37 publications

Characteristics and outcomes of in vitro fertilization in different phenotypes of polycystic ovary syndrome

Characteristics and outcomes of in vitro fertilization in different phenotypes of polycystic ovary syndrome

Effects of previous ovarian drilling on cumulative ongoing pregnancy rates among patients with polycystic ovarian syndrome undergoing in vitro fertilization

Polycystic Ovary Syndrome, Obesity, and Pregnancy

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