Is polycystic ovarian syndrome and insulin resistance associated with abnormal uterine bleeding in adolescents?

Abstract

Objectives:The aim of the study was to determine if adolescents with juvenile bleeding had polycystic ovarian syndrome (PCOS) and insulin resistance. Material and methods:The study was conducted in a group of 43 females aged 12-18 years, diagnosed with juvenile menorrhagia, and 37 healthy female adolescents aged 12-18 years. The study was conducted during the early follicular phase of the menstrual cycle. Menstrual cycle disturbances, acne and hirsutism were recorded. Ultrasound scan determining the condition of the ovaries was conducted. Laboratory tests of the glucose level, cholesterol, LDL and HDL cholesterol and triglycerides fraction, DHEAS, FSH, LH, insulin, SHGB, total testosterone, androstenedione, and free testosterone have been established. Results:The occurrence of regular menstrual cycles (30.23%, p = 0.006) was significantly lower in the juvenile bleeding group. Also, secondary amenorrhea was significantly more likely to be recognized in this group of females (p = 0.03). The concentration of FSH was considerably lower (p = 0.0002) in the group of adolescents with AUB. Conclusions:Adolescents with abnormal uterine bleeding (AUB) are often diagnosed with secondary amenorrhea, and PCOS. The group with a diagnosis of juvenile bleeding was also diagnosed with higher rates of insulin resistance.

A Traditional Chinese Medicine for the Treatment of Endometrial Hyperplasia via Regulating the HPO Axis in Rats

“…The area of damaged and ischemic necrotic tissue gradually expanded and the permeability of blood vessel wall boosted, eventually leading to tissue exfoliation [ 40 , 41 ]. Anovulatory DUB results from the prolonged estrogen and limited progestin expression, which can trigger endometrium growth dramatically and cause breakthrough-estrogen-bleeding in females [ 42 , 43 ]. Importantly, our findings demonstrated that pinopodes in EH rats gradually returned to functional morphology after SCS administration, showing that the drug had an inhibitory effect on EH and was more significant than the contrastive drug GXN.…”

Molecular mechanisms of a traditional Chinese medicine in the treatment of dysfunctional uterine bleeding

“…The area of the damaged and ischemic necrotic tissue gradually expanded, the permeability of the blood vessel wall boosted, and nally the tissue was exfoliated (Jarrell, 2018;Lichten, 2018). Anovulatory DUB due to the effects of prolonged E and no progestin' s counteracting effect, the endometrium continues to proliferate and even proliferate to varying degrees, eventually leading to breakthrough-estrogen-bleeding (Jones and Sung, 2020;Urbanska et al, 2019). What's worse, it is di cult to identify the location, depth, scope and timing of the degradation and fall.…”

A traditional Chinese Medicine Proves the Treatment of Endometrial Hyperplasia Via Regulating the HPO Axis in Rats

“…The area of the damaged and ischemic necrotic tissue gradually expanded and the permeability of the blood vessel wall boosted, eventually leading to tissue exfoliation (Jarrell, 2018;Lichten, 2018). Anovulatory DUB results from the prolonged E and limited progestin expression, which can trigger the endometrium growth dramatically and cause breakthrough-estrogen-bleeding in females (Jones and Sung, 2020;Urbanska et al, 2019). Importantly, our ndings demonstrate that the pinopodes of EH rats can gradually return to functional morphology after SCS administration, which proves that the drug has an inhibitory effect on endometrial hyperplasia and is much better than the contrastive drug GXN.…”