Objective:To determine the incidence of immediate and delayed adverse drug reactions (ADRs), and to assess patient discomfort following administration of iodixanol during imaging examinations in routine clinical practice.Methods:A total of 20 185 patients across 95 clinical centres were enrolled in a prospective post-marketing surveillance registry with iodixanol. Patients were monitored for occurrence of ADRs immediately following iodixanol administration and for up to 7 days after administration.Results:The overall rate of ADRs was 1.52%, of which 0.58% was immediate and 0.97% was delayed onset. Two patients had non-fatal serious ADRs (0.01%). The ADRs were significantly more common in patients who underwent contrast-enhanced CT/coronary CT angiography vs others (p < 0.001), in those receiving pre-heated iodixanol vs non-heating (p < 0.001), in those aged 70 years or younger (p < 0.001), in those in whom a power injector was used for contrast delivery (p < 0.001) and in those with a history of an allergic reaction to contrast (p = 0.024). Multivariate analysis showed that female gender, intravenous route of contrast injection, body weight ≥80 kg, age less than 65 years, contrast flow rate ≥4 ml s−1 and prior reaction to iodinated contrast medium were all significant and independent contributors to ADRs. Pre-treatment contrast volume and history of cardiac disease, gout, hypertension, diabetes mellitus or asthma did not affect the rate of ADRs. Discomfort was generally mild, with 94.8% of patients reporting a composite score of 0–3.Conclusion:The safety of iodixanol in routine clinical practice was shown to be similar to the published safety profiles of other non-ionic iodinated contrast agents. Patient discomfort during administration was mild or absent in most patients.Advances in knowledge:The major strength of this study is that it included 20 185 patients enrolled in various types of imaging examinations. The safety profile of iodixanol was comparable to previously published work.

To study the effect of the dip angle of the inducer blade section in the meridian plane on the cavitation performance of the high-speed centrifugal pump, four schemes of the inducer have been considered only by changing the dip angle of the blade section in the meridian plane while keeping the other geometrical parameters unchanged. Based on the RNG k-ɛ turbulence model and Zwart-Gerber-Belamri cavitation model, three-dimensional numerical simulation of a high-speed centrifugal pump is carried out. The results show that the cavitation performance of high-speed centrifugal pump will be improved when the dip angle of the blade section in the meridian plane increases within a certain range, but the cavitation performance will deteriorate when the dip angle exceeds a certain extent. A moderate raise of the blade section dip angle will change the blade inlet angle and blade outlet angle of the shroud and hub of the inducer, improve the matching of the liquid flow angle with the blade inlet angle and restrain the cavitation at the blade leading edge. The change in the dip angle has a weak influence on the external performance of the high-speed centrifugal pump, indicating that there is almost no effect on the capacity of the inducer.

Gamma-Fe2.6Ni1.4 nanoparticles were prepared by the arc-discharge method as the precursor and its nitride counterpart of gamma'-Fe2.6Ni14N nanoparticles was synthesized directly through a thermal ammonolysis reaction at the temperature of 673 K for two hours. The resultant product was identified as a homogeneous ternary nitride with nearly spherical shape and average size of about 60.0 nm. The electromagnetic characteristics of gamma'-Fe2.6Ni1.4N derivant and gamma-Fe2.6Ni1.4 precursor have been studied in the frequency range of 2-18 GHz. Compared with the precursor, gamma'-Fe2.6Ni1.4N nanoparticles exhibits an enhanced electromagnetic absorption property resulted from the increased dielectric loss by nitriding process. The optimal reflection loss (RL) of gamma'-Fe2.6Ni1.4N nanoparticles/paraffin composite can reach -39.9 dB at 5.2 GHz in a thickness of 2.29 mm, and the frequency band corresponding RL < -10 dB is over 2.6-18 GHz in the thickness range of 0.78-4.20 mm.

a b s t r a c tRunning impellers have a great influence on the velocity distribution and the flow structure in an oxidation ditch (OD). In this paper, the dimensional analysis and computational fluid dynamics methods were used to study the influence of rotational speed of impellers on the average velocity of the flow in an OD. The time-averaged Navier-Stokes (N-S) equations with a three-dimensional (3D) renormalized group (RNG) k-ε turbulence model were solved by FLUENT6.3.26 for the velocity and pressure fields. By the dimensional analysis and simulation results, the relation between the rotational speed of impellers and the average velocity of the flow was obtained, which can provide a reference in the designing of ODs.

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