Is primary dysmenorrhea a precursor of future endometriosis development?

Clemenza, Sara; Vannuccini, Silvia; Capezzuoli, Tommaso; Meleca, Chiara Immacolata; Pampaloni, Francesca

doi:10.1080/09513590.2021.1878134

Cited by 33 publications

(22 citation statements)

References 82 publications

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“…It is important to consider that CPP and dysmenorrhea usually start during adolescence, but treatments are often started several years later and are not always adequate to limit or reduce the progression of endometriosis. Early diagnosis and treatment are essential in order to decrease neoangiogenesis and neuroinflammation and thus the chronic inflammatory status, and preserve future fertility [ 34 ]. Pain symptoms usually reappear when estrogen-progestin or only progestin intake is discontinued.…”

Section: Discussionmentioning

confidence: 99%

Randomized study on the effectiveness of nomegestrol acetate plus 17β-estradiol oral contraceptive versus dienogest oral pill in women with suspected endometriosis‑associated chronic pelvic pain

et al. 2022

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Background To evaluate the effects of a combined oral contraceptive containing 1.5 mg 17b-estradiol (E2) and 2.5 mg nomegestrol acetate (NOMAC) or 2 mg/daily dienogest (DNG) oral progestin on endometriosis-associated chronic pelvic pain (CPP) and on the quality of life (QoL) and sexual function, by a randomized study design. Methods The E2/NOMAC group and DNG group included 99 and 98 women, respectively. The levels of CPP were measured by the visual analogic scale (VAS). The QoL scores were investigated by the Short Form-36 questionnaire (SF-36). Finally, sexual function was studied using the Female Sexual Function Index (FSFI), while sexual distress was studied by the Female Sexual Distress Scale (FSDS). The study had 3, 6 and 12-month follow-ups. Results The intra-group analysis showed an improvement of the VAS score from baseline to the 12-month follow-up in the women of both groups (p < 0.001). The inter-group comparison showed a similar improvement of CPP (p = 0.06). Women on DNG had better SF-36 somatic (p < 0.01) and FSFI scores (p < 0.006) than women on E2/NOMAC at the 6- and 12-month follow-ups. Conclusions The results support the efficacy of both hormonal treatments, even if DNG was more effective than E2/NOMAC in a limited intergroup comparison.

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Section: Discussionmentioning

confidence: 99%

Randomized study on the effectiveness of nomegestrol acetate plus 17β-estradiol oral contraceptive versus dienogest oral pill in women with suspected endometriosis‑associated chronic pelvic pain

et al. 2022

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“…Early diagnosis and treatment are essential in order to decrease neoangiogenesis and neuroin ammation and so the chronic in ammatory status, and preserve future fertility. 27 Pain symptoms usually reappear when estrogen-progestin or only progestin intake is discontinued. In fact, progestins and combined hormonal contraceptives do not eliminate endometriotic lesions but induce their quiescence.…”

Section: Discussionmentioning

confidence: 99%

Randomized Study on the Effectiveness of Nomegestrol Acetate Plus 17β-Estradiol Oral Contraceptive vs Dienogest Oral Pill in Women with Endometriosis‑Associated Chronic Pelvic Pain

Caruso

Cianci

Sareri

et al. 2022

Preprint

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Background: To evaluate the effects of a combined oral contraceptive containing 1.5mg 17b-estradiol (E2) and 2.5mg nomegestrol acetate (NOMAC) or 2 mg/daily dienogest (DNG) oral progestin on endometriosis-associated chronic pelvic pain (CPP) and on the quality of life (QoL) and sexual function, by a randomized study design.Methods: The E2/NOMAC group and DNG group included 99 and 98 women, respectively. The levels of CPP were measured by the visual analogic scale (VAS). The QoL scores were investigated by the Short Form-36 (SF-36). Finally, the sexual function was studied using the Female Sexual Function Index (FSFI), while the sexual distress by the Female Sexual Distress Scale (FSDS). The study had 3, 6 and 12-month follow-ups. Results: The intra-group analysis showed an improvement of the VAS score from baseline to the 12-month follow-up in women of both groups (p<0.001). The inter-group comparison showed a similar improvement of CPP (p=0.06). Women on DNG had better SF-36 somatic (p<0.01) and FSFI scores (p<0.006) than women on E2/NOMAC at 6- and 12-month follow-ups. Conclusions: The results support the efficacy of both hormonal treatments, even if DNG was more effective than E2/NOMAC in a limited intergroup comparison.The research protocol was approved by the institutional review board of the Ethics Committee of the University Hospital Polyclinic, Catania, Italy, registered n. 109/2017/PO

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“…Secondary dysmenorrhea refers to painful menses due to other pathological conditions, such as endometriosis, adenomyosis, uterine fibroids and pelvic inflammatory disease. 14,15 Endometriosis is the most common cause of secondary dysmenorrhea, the pain intensity is usually vary from mild to severe. 16,17 Despite the high prevalence, many women with dysmenorrhea do not report it and seek medical care, because it is accepted as a normal aspect of the menstrual cycle and therefore is tolerated.…”

Section: Dysmenorrheamentioning

confidence: 99%

“…18 The most widely accepted explanation for the pathogenesis of dysmenorrhea have been identified as a hyperproduction of uterine prostaglandins (PG), particularly PGF2a and PGE2 thus resulting in increased uterine tone and high amplitude contraction. 14,17 Higher circulating levels of PGF2a and PGE2 have been reported in women with dysmenorrhea compared with asymptomatic women during menstruation. 15 Peritoneal fluid of women with endometriosis consist more macrophage, the inflammatory environment of this disease points out an increased production of oestrogen, which in turn will stimulates more PG through the activation of both NFk Band Cyclooxygenase-2 (COX-2).…”

Section: Dysmenorrheamentioning

confidence: 99%

Gynaecologic History During Adolescence to Predict Endometriosis Earlier

Hartati¹,

Ocviyanti²,

Amin³

et al. 2022

Bioscmed

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Background. Endometriosis is a chronic gynecological disorder that generally affects women of reproductive age which is characterized by implantation of endometrial tissue, both glands and stroma outside the uterus. Research shows that the initial onset of endometriosis patients begins in adolescence. The high prevalence with atypical symptoms leads to long term delay in establishing the appropriate diagnosis. Further developments in the field of early endometriosis screening will greatly assist clinicians, especially general practitioners in areas with limited health facilities, in early detection of endometriosis. Methods. Using the electronic databases, comprehensive literature searches were conducted with the specific keywords. Full-text manuscripts published were reviewed for relevancy and importantly, reference lists were cross-checked for additional relevant studies. Results. Dysmenorrhea, chronic pelvic pain, dyspareunia, dysuria, dyschezia, and glycoprotein were found dominantly in all analyzed literature. The occurrence of endometriosis affects the functioning of women in multiple aspects of life. Endometriosis places a significant burden on teens and adult women, their families, and society as a whole. Conclusion. Combination of structured past history taking, and several biomarker level might be useful as a screening tool that easy to use and cost effective, as early diagnosis is expected to prevent further progression of endometriosis especially in adolescence.

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Is primary dysmenorrhea a precursor of future endometriosis development?

Cited by 33 publications

References 82 publications

Randomized study on the effectiveness of nomegestrol acetate plus 17β-estradiol oral contraceptive versus dienogest oral pill in women with suspected endometriosis‑associated chronic pelvic pain

Randomized study on the effectiveness of nomegestrol acetate plus 17β-estradiol oral contraceptive versus dienogest oral pill in women with suspected endometriosis‑associated chronic pelvic pain

Randomized Study on the Effectiveness of Nomegestrol Acetate Plus 17β-Estradiol Oral Contraceptive vs Dienogest Oral Pill in Women with Endometriosis‑Associated Chronic Pelvic Pain

Gynaecologic History During Adolescence to Predict Endometriosis Earlier

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