Is prolactin involved in etiopathogenesis of psoriasis?

Görpelioğlu, Canan; Güngör, Emel; Allı, Nuran

doi:10.1111/j.1468-3083.2007.02559.x

Cited by 14 publications

(19 citation statements)

References 8 publications

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“…However, there was no variation of serum prolactin levels with reference to the PASI score. Gorpelioglu et al 11 also reported similar findings in their study of 39 psoriasis patients and 36 controls. However, they did not consider increased prolactin levels in their nine patients and five controls significant as these were below 100 ng/ml, the minimum limit for the diagnosis of prolactinoma.…”

supporting

confidence: 65%

Serum prolactin levels in patients with psoriasis

Khatri

Mahajan

Mehta

et al. 2017

Indian Journal of Medical Research

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supporting

confidence: 65%

Serum prolactin levels in patients with psoriasis

Khatri

Mahajan

Mehta

et al. 2017

Indian Journal of Medical Research

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“…Although many studies found increased serum PRL in patients with psoriasis (Giasuddin et al, 1998;Dilmé-Carreras et al, 2011), there is controversy, however, as to whether raised PRL levels are associated with disease activity. Gorpelioglu et al and Priestley et al did not find any association between serum PRL levels and psoriasis as well as its activity (Gorpelioglu et al, 2008;Priestley et al, 1984). In contrast, a number of investigators have found a significant association between serum PRL and disease activity (Giasuddin et al, 1998;Dilmé-Carreras et al, 2011;Sanch, 2000).…”

Section: Discussionmentioning

confidence: 86%

“…Psoriasis is a T-cell-mediated autoimmune skin disease characterized by hyperproliferation, abnormal differentiation of keratinocytes, presence of inflammatory cell infiltrate and alterations to the dermal capillaries (Gorpelioglu et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Serum prolactin levels in dermatological diseases: A case–control study

Elsherif

El-Sherif

El-Dibany

2015

Journal of Dermatology & Dermatologic Surgery

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Background: Recent lines of evidence suggest that prolactin (PRL) as a neurohormone may play a role in the activity of psoriasis and some other immune-mediated diseases. Our aim was to evaluate the correlation between serum PRL levels and severity of psoriasis, vitiligo and alopecia areata.Patients and methods: We performed a case-control study on 100 subjects: 75 patients; suffering from psoriasis, vitiligo and alopecia areata; 25 patients in each group and 25 age-and sex-matched healthy controls.Results: Serum prolactin levels were significantly high in all three dermatological diseases in comparison with the control group (P = 0.000). The mean ± SD of the serum prolactin levels was 21.8 ± 11.5 ng/ml, 16.9 ± 6.8 ng/ml, and 16.6 ± 8.0 ng/ml in patients with alopecia areata, psoriasis and vitiligo respectively. Moreover, the serum prolactin levels in patients with alopecia areata and psoriasis were significantly correlated with disease severity (P < 0.05), however no statistically significant correlation was noted between vitiligo severity and serum prolactin levels (P > 0.05).Conclusions: Prolactin may play a role in the pathogenesis of alopecia areata, psoriasis, and vitiligo; and may serve as a biological marker of disease activity in patients with psoriasis and alopecia areata. Ó 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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“…4 Previous studies have assessed the association of PRL levels with psoriasis as a hyperproliferative cutaneous disease of multifactorial etiology; however, the results seem contradictory. [5][6][7] Epidermal hyperproliferation that is observed in both psoriasis and atopic dermatitis and its underlying mechanisms are not completely understood by now. PRL levels in children with AD.…”

Section: Introductionmentioning

confidence: 99%

“…7 PRL levels have been reported to be higher in psoriasis patients in some studies 6,7 , while some other studies claimed no significant difference. 5,12 The mechanisms underlying the keratinocyte h y p e r p r o l i f e r a t i o n w h i c h i s o b s e r v e d i n inflammatory skin diseases such as atopic dermatitis and psoriasis are not fully understood yet, although especially growth factors and cytokines, such as TNF-α, IFN-γ and IL-1 are involved in the growth of keratinocytes. 13 According to the studies, PRL is involved in the psoriasis etiopathogenesis.…”

mentioning

confidence: 99%

Serum prolactin levels in atopic dermatitis and the relationship with disease severity

2017

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Background. Prolactin performs as a neuroendocrine modulator of skin epithelial cell proliferation and the skin immune system. Objective. The aim was to assess the serum prolactin levels in patients with atopic dermatitis and the relationship with disease severity. Methods. The study was performed on 46 patients with atopic dermatitis and 100 healthy controls aged between 0.5 years and 19.5 years. The diagnosis of atopic dermatitis was based on clinical findings and the severity of the disease was documented. Venous blood sampling was performed in order to measure prolactin levels. Results. Prolactin levels in atopic dermatitis were not different from controls and there was no relationship between the severity of atopic dermatitis and serum prolactin levels. Prolactin may not have a role in the pathogenesis of atopic dermatitis. Further studies with larger sample sizes and measurement of prolactin levels in the skin may help to understand the role of prolactin in the pathogenesis of atopic dermatitis.

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Is prolactin involved in etiopathogenesis of psoriasis?

Cited by 14 publications

References 8 publications

Serum prolactin levels in patients with psoriasis

Serum prolactin levels in patients with psoriasis

Serum prolactin levels in dermatological diseases: A case–control study

Serum prolactin levels in atopic dermatitis and the relationship with disease severity

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