Serum prolactin levels in dermatological diseases: A case–control study

Elsherif, Nadia Abdalhafid; El-Sherif, Abdalla I; El-Dibany, Salwa A.

doi:10.1016/j.jdds.2015.03.002

Cited by 4 publications

(8 citation statements)

References 15 publications

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“…The positive relationship between mean prolactin concentration and the number of GI events is an interesting finding that should be explored in more detail. Studies in humans have also revealed a role of prolactin in the pathogenesis of certain skin pathologies [105, 106], with significantly higher serum prolactin in patients with psoriasis, vitiligo and alopecia areata, when compared to controls [107]. The phenomenon of hyperprolactinemia has previously been associated with reproductive dysfunction in African elephants living in North American zoos [108, 109] and these results suggest there may be other impacts on health, which should be explored further.…”

Section: Discussionmentioning

confidence: 99%

Relationships between housing and management factors and clinical health events in elephants in North American zoos

et al. 2019

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Elephants experience a number of health issues that can contribute to their well-being and survival. In managed populations, housing conditions and management practices can influence individual health, so potential risk factors associated with morbidity or mortality should be identified to ensure the best possible standards of care. The goal of this study was to determine if the number of clinical events experienced could be a useful welfare indicator in zoo elephants, and to determine factors associated with key pathologies. We used an epidemiological approach to investigate how intrinsic (species, sex, age) and extrinsic (housing, management) factors were associated with both the total number of clinical events, and each of the four most prevalent pathology types (gastrointestinal issues, skin lesions, lameness, foot lesions), over a 12-month period. The study included 220 (127 African; 93 Asian) elephants housed at 61 facilities across North America. More than 1100 clinical events were identified. Species and sex differences were apparent in the types of pathology encountered, and unsurprisingly, the number of clinical events was positively correlated with age. Factors relating to housing (percent time with indoor/outdoor choice, space experience inside, number of unique environments an elephant was housed in, percent time on soft substrate) and management (enrichment diversity, spread of feeding opportunities) were also related to the number of clinical events. However, relationships were often counter to our initial hypotheses, highlighting caution in assuming cause and effect from correlational analyses such as these. Other welfare indicators such as serum and fecal glucocorticoids and serum prolactin were also associated with health status, being higher or more variable in individuals with a greater number of events. This approach provides insight into housing and management factors related to the health of these species in zoos, and in some cases, may reflect management changes that have already been made to mitigate existing or anticipated health concerns.

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Section: Discussionmentioning

confidence: 99%

Relationships between housing and management factors and clinical health events in elephants in North American zoos

et al. 2019

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“…[ 9 10 ] Accordingly, both studies denied a possible role of prolactin in the pathogenesis of AA, something we could not state owing to the further studying of the prolactin receptor. On the contrary, two other studies documented a significantly elevated level of serum prolactin in AA patients compared to controls,[ 11 12 ] and that serum prolactin level was significantly correlated with disease severity. [ 11 ]…”

Section: Discussionmentioning

confidence: 93%

“…On the contrary, two other studies documented a significantly elevated level of serum prolactin in AA patients compared to controls,[ 11 12 ] and that serum prolactin level was significantly correlated with disease severity. [ 11 ]…”

Section: Discussionmentioning

confidence: 93%

“…The role played by prolactin in AA is not clear yet, as previous reports yielded controversial results,[ 9 10 11 12 ] and one study showed no change in its level following therapy. [ 12 ] Hence, the current study was conducted to measure the serum level of prolactin, as well as to detect the expression of its receptor in AA patients, in an attempt to verify their possible role in the pathogenesis of this disease.…”

Section: Introductionmentioning

confidence: 99%

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Do prolactin and its receptor play a role in alopecia areata?

et al. 2018

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“…PRL appears to have extra capacities in skin science and hair follicle development also. This notable chemical has been acknowledged in a few articles as an immunostimulatory factor in immune system issues like psoriasis and lupus erythematosus [3].…”

Section: Introductionmentioning

confidence: 99%