Is Propranolol Effective in Primary Polydipsia?

Kishi, Yasuhiro; Kurosawa, Hisashi; Endo, Shunkichi

doi:10.2190/qpwl-14h7-hpgg-a29d

Cited by 14 publications

(6 citation statements)

References 12 publications

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“…. Treatment effects by angiotensin‐converting enzyme (ACE) inhibitors (captopril 31,32 and enalapril 33 ), beta‐blockers (propranolol 34–36 ), opioid antagonists (naloxone 37 ), demeclocycline* 38 , carbamazepine 39 , and lithium 40,41 have been reported but sample sizes of these studies are small and the assessments are inconsistent 42 . Furthermore, the risk of side effects occurring due to concomitant use is not clear, so there is no desirable pharmacotherapy 2D .…”

Section: Cq5‐5 Is There a Recommended Pharmacotherapy For Psychosis‐related Polydipsia And Water Intoxication?mentioning

confidence: 99%

Japanese Society of Neuropsychopharmacology: “Guideline for Pharmacological Therapy of Schizophrenia”

2021

Neuropsychopharm Rep

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Section: Cq5‐5 Is There a Recommended Pharmacotherapy For Psychosis‐related Polydipsia And Water Intoxication?mentioning

confidence: 99%

Japanese Society of Neuropsychopharmacology: “Guideline for Pharmacological Therapy of Schizophrenia”

2021

Neuropsychopharm Rep

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“…However, studies have been small and inconsistent. 8,9 Propranolol, 10 a beta adrenergic receptor blocker; irbesartan, 11 an angiotensin-II receptor blocker; demeclocycline, 12 a tetracycline that inhibits antidiuretic hormone action; and naltrexone, 9 a mu opioid antagonist, have been studied with inconclusive results and a variety of adverse effects 5,7,13 (Table 2 [8][9][10][11][12][13] ).…”

Section: The Authors' Observationsmentioning

confidence: 99%

An unquenchable thirst

Gallop¹

2021

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“…Blokada receptorów β-adrenergicznych w nerce skutkuje spadkiem wydzielania reniny, a pośred-nio również angiotensyny II. Wykazano, że β-blokery takie jak propranolol [49] czy pindolol [50] mogą skutecznie zmniejszać nasilenie polidypsji psychogennej i normalizować poziom sodu w osoczu. Podobne obserwacje poczyniono w odniesieniu do inhibitorów konwertazy angiotensyny.…”

Section: Leczenieunclassified

“…β-adrenergic receptor blockade in kidneys reduced the secretion of renin, and indirectly also angiotensin II. It has been shown that β-blockers such as propranolol [49] and pindolol [50] can effectively reduce the severity of psychogenic polydipsia and normalise the level of sodium in plasma. Similar observations have been made in relation to angiotensin convertase inhibitors.…”

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confidence: 99%

Hiponatremia in the practice of a psychiatrist. Part 2: psychogenic polydipsia

Gerhant

Słotwiński

Hołownia

et al. 2017

Current Problems of Psychiatry

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Objective. The study is the second part of the literature review on hyponatremia in patients with diagnosed mental disorders. This article focuses on psychogenic polydipsia as, along with the SIADH, one of the two most common causes of hyponatremia in the mentioned group of patients.Method: The literature review was based on searching the Medline, the Google Scholar and the Ebsco databases in Polish and English by entering the following phrases: psychogenic polydipsia, the psychosis -intermittent hyponatremia -polydipsia syndrome, water intoxication.Discussion: Psychogenic polydipsia occurs in up to 25% of patients treated for mental disorders. It most frequently concerns patients with schizophrenia. 30% of patients with psychogenic polydipsia suffer from hyponatremia with or without symptoms of water intoxication. In the etiology of psychogenic polydipsia, the influence of dopaminergic and noradrenergic neurotransmission has been considered, as well as angiotensin, which is claimed to have dipsogenic properties. In order to reduce the severity of the disorder, attempts have been made to administer the following groups of medications: β-blockers, opioid receptor antagonists, angiotensin convertase inhibitors and angiotensin receptor antagonists. Other methods include replacing classic antipsychotic drugs with clozapine. There are also reports of a reduced severity of polydipsia with hyponatremia after introducing risperidone and olanzapine. Preventing episodes of water intoxication in patients with psychogenic polydipsia requires the monitoring of their body weight and a suitable reduction of fluid intake by them.Results: Mentally ill patients, especially those with chronic schizophrenia, should be monitored for psychogenic polydipsia and the concomitant hyponatremia. Keywords: psychogenic polydipsia, hyponatremia, water intoxication StreszczenieCel. Praca jest drugą częścią przeglądu literatury na temat hiponatremii u pacjentów z rozpoznaniem zaburzeń psychicznych. W niniejszym artykule skoncentrujemy uwagę na polidypsji psychogennej jako jednej z dwóch, obok zespołu SIADH, najczęstszych przyczyn hiponatremii w tej grupie chorych.Metoda: Przeglądu literatury dokonaliśmy przeszukując bazy danych Medline, Google Scholar i Ebsco w języku polskim i angielskim, wpisując hasła: polidypsja psychogenna, zespół psychoza -hiponatremia przerywana -polidypsja, zatrucie wodne.Omówienie: Polidypsja psychogenna występuje nawet u 25% pacjentów leczonych z powodu zaburzeń psychicznych. Najczęściej dotyczy pacjentów chorych na schizofrenię. U 30 % pacjentów z polidypsją psychogenną występuje hiponatremia z objawami lub bez objawów zatrucia wodnego. W etiologii polidypsji psychogennej rozważano znaczenie neuroprzekaźnictwa dopaminergicznego, noradrenergicznego, jak również angiotensyny, której przypisuje się właściwości dipsogenne. W celu zmniejszenia jej nasilenia podejmowano próby stosowania takich grup leków jak: β-blokery, antagoniści receptorów opioidowych, inhibitory konwertazy angiotensyny czy antagoniści receptoró...

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Is Propranolol Effective in Primary Polydipsia?

Cited by 14 publications

References 12 publications

Japanese Society of Neuropsychopharmacology: “Guideline for Pharmacological Therapy of Schizophrenia”

Japanese Society of Neuropsychopharmacology: “Guideline for Pharmacological Therapy of Schizophrenia”

An unquenchable thirst

Hiponatremia in the practice of a psychiatrist. Part 2: psychogenic polydipsia

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