2014
DOI: 10.1164/rccm.201409-1702ed
|View full text |Cite
|
Sign up to set email alerts
|

Is Pulmonary Hypertension a Metabolic Disease?

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
5
0

Year Published

2016
2016
2020
2020

Publication Types

Select...
5

Relationship

3
2

Authors

Journals

citations
Cited by 6 publications
(7 citation statements)
references
References 19 publications
2
5
0
Order By: Relevance
“…Nowadays, although PAH patients report clinical and hemodynamic improvement with sildenafil monotherapy the prognosis of the disease remains serious and search for the ways to improve treatment efficacy continues. PAH is increasingly recognized as a metabolic disease associated with OS [1] , [31] , [4] , which was confirmed in present study. Patients with PAH were characterized by increased HNE in blood, changes in the FAs composition with high levels of saturated and unsaturated (oleic, LA, DHA) acids in phospholipids as well as reduced HRV with sympathetic predominance.…”
Section: Discussionsupporting
confidence: 87%
“…Nowadays, although PAH patients report clinical and hemodynamic improvement with sildenafil monotherapy the prognosis of the disease remains serious and search for the ways to improve treatment efficacy continues. PAH is increasingly recognized as a metabolic disease associated with OS [1] , [31] , [4] , which was confirmed in present study. Patients with PAH were characterized by increased HNE in blood, changes in the FAs composition with high levels of saturated and unsaturated (oleic, LA, DHA) acids in phospholipids as well as reduced HRV with sympathetic predominance.…”
Section: Discussionsupporting
confidence: 87%
“…Collectively, these data suggest that glucose regulates Smurf-1 expression, which influences Smad activation in IPAH through proteasomal degradation. These findings validate the findings of previous reports indicating metabolic abnormalities in IPAH (37,39) …”
Section: Glucose Levels Regulate Smurf-1 Expression and P-smad 1/5/8 supporting
confidence: 92%
“…Collectively, this report suggests that altered BMP signaling in IPAH can result independent of BMPR2 mutation status. We put forth the notion that Smurf-1 expression is stimulated by glucose, which has been confirmed to be dysregulated in the lungs of patients with IPAH (35)(36)(37)(38)(39), and may trigger the degradation of BMP-regulated Smads and reduction in Smad activation. The role of glucose in the regulation of Gremlin-1 expression in IPAH is also discussed.…”
Section: Pulmonary Arterial Hypertension (Pah)mentioning
confidence: 98%
“…In recent years, metabolic dysregulation has emerged as an important pathway in IPAH. 4,5 Altered glucose homeostasis and dyslipidemia have been documented in PAH and associated with worse outcomes. [6][7][8][9][10] Metabolism has not been studied in CTEPH.…”
Section: Introductionmentioning
confidence: 99%