Is residual renal function and better phosphate control in peritoneal dialysis an answer for the lower prevalence of valve calcification compared to hemodialysis patients?

Rroji, Merita; Seferi, Saimir; Cafka, Majlinda; Petrela, Elizana; Likaj, Erjola; Barbullushi, Myftar; Thereska, Nestor; Spasovski, Goce

doi:10.1007/s11255-013-0438-7

Cited by 32 publications

(30 citation statements)

References 43 publications

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“…A previous study confirmed that residual renal function (RRF) is one of the key determinants of P control in PD patients. In the present study, we found that the PD group had higher RRF, which led to lower P and Ca×P product levels compared to HD patients [19]. This finding may be explained by the lower salivary P level in PD group than that in the HD group.…”

Section: Discussionsupporting

confidence: 46%

Differences in Dental Calculus Indices and Salivary Calcium and Phosphate Levels in Children With Chronic Kidney Disease Undergoing Hemodialysis and Peritoneal Dialysis Therapy

Kirana

Sutadi

Budiardjo

2018

Asian J Pharm Clin Res

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Objective: The objective of this study is to analyze the differences in dental calculus indices and calcium and phosphate levels in children with chronic kidney disease undergoing hemodialysis (HD) and peritoneal dialysis (PD) therapy. Methods:In this cross-sectional study, 15 children undergoing HD therapy and 15 undergoing PD therapy were subjected to intraoral examination for dental calculus indices. Whole unstimulated saliva samples of all subjects were collected and subjected to calcium and phosphate analysis. Statistical analyses were conducted using the Mann-Whitney and independent t-tests. Results:The dental calculus indices were significantly lower and salivary calcium level was significantly higher in the PD group than those in the HD group (p<0.05). The salivary phosphate level was lower in the PD group (p≥0.05) but without significance. Conclusion:The PD group had lower dental calculus indices and higher salivary calcium level. The higher salivary phosphate levels in the HD group may have contribute to the higher dental calculus indices, probably because phosphate plays an important role in dental calculus formation.

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Section: Discussionsupporting

confidence: 46%

Differences in Dental Calculus Indices and Salivary Calcium and Phosphate Levels in Children With Chronic Kidney Disease Undergoing Hemodialysis and Peritoneal Dialysis Therapy

Kirana

Sutadi

Budiardjo

2018

Asian J Pharm Clin Res

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“…An American cross-sectional study found more frequent CAC in pediatric patients on hemodialysis (9/21 patients) than on peritoneal dialysis (2/17 patients) [11]. An Albanian cross-sectional study found more frequent cardiac valve calcification in adult patients on hemodialysis (24/34 patients) than on peritoneal dialysis (10/30 patients) [12]. A Korean cross-sectional study did not find a significant difference in CAC score between patients on hemodialysis (n = 31, median score 30) and those on peritoneal dialysis (n = 15, median score 16) [13].…”

Section: Discussionmentioning

confidence: 99%

“…However, there have never been randomized studies on this subject, as randomization to dialysis modality is generally refused by patients [9]. Moreover, patients on peritoneal dialysis are typically younger and healthier due to the prerequisites of treatment at home [10], which has hampered previous observational research that did not attempt to statistically adjust for this [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Coronary Artery Calcification in Hemodialysis and Peritoneal Dialysis

et al. 2018

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Background: Vascular calcification is seen in most patients on dialysis and is strongly associated with cardiovascular mortality. Vascular calcification is promoted by phosphate, which generally reaches higher levels in hemodialysis than in peritoneal dialysis. However, whether vascular calcification develops less in peritoneal dialysis than in hemodialysis is currently unknown. Therefore, we compared coronary artery calcification (CAC), its progression, and calcification biomarkers between patients on hemodialysis and peritoneal dialysis. Methods: We measured CAC in 134 patients who had been treated exclusively with hemodialysis (n = 94) or peritoneal dialysis (n = 40) and were transplantation candidates. In 57 of them (34 on hemodialysis and 23 on peritoneal dialysis), we also measured CAC progression annually up to 3 years and the inactive species of desphospho-uncarboxylated matrix Gla protein (dp-ucMGP), fetuin-A, osteoprotegerin. We compared CAC cross-sectionally with Tobit regression. CAC progression was compared in 2 ways: with linear mixed models as the difference in square root transformed volume score per year (ΔCAC SQRV) and with Tobit mixed models. We adjusted for potential confounders. Results: In the cross-sectional cohort, CAC volume scores were 92 mm³ in hemodialysis and 492 mm³ in peritoneal dialysis (adjusted difference 436 mm³; 95% CI –47 to 919; p = 0.08). In the longitudinal cohort, peritoneal dialysis was associated with significantly more CAC progression defined as ΔCAC SQRV (adjusted difference 1.20; 95% CI 0.09 to 2.31; p = 0.03), but not with Tobit mixed models (adjusted difference in CAC score increase per year 106 mm³; 95% CI –140 to 352; p = 0.40). Peritoneal dialysis was associated with higher osteoprotegerin (adjusted p = 0.02) but not with dp-ucMGP or fetuin-A. Conclusions: Peritoneal dialysis is not associated with less CAC or CAC progression than hemodialysis, and perhaps with even more progression. This indicates that vascular calcification does not develop less in peritoneal dialysis than in hemodialysis.

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“…Recently, similar results are presented Rroji and associates. 23 Furthermore, it is worth mentioning that there was no significant difference of values serum calcium and intact parathyroid hormone in the patients with and without CVCs at the end of the monitoring period.…”

Section: Discussionmentioning

confidence: 82%

Valvular calcification and left ventricular modifying in peritoneal dialysis patients

Rebić¹,

Rašić²,

Hamzić-Mehmedbašić³

et al. 2015

Renal Failure

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Background: Cardiac valve calcification (CVC) and left ventricular (LV) alterations are frequent complication in end-stage renal disease (ESRD). We determined the prevalence of CVC and LV hypertrophy (LVH) in ESRD patients before renal replacement therapy and 12 months after peritoneal dialysis (PD). Methods: A prospective longitudinal of 50 incident PD patients was studied. Demographic and clinical data were recorded and blood assayed at baseline and after 1-year of follow-up. CVC and LVH were evaluated by M-mode two-dimensional echocardiography. Results: CVC of the mitral and aortic valves and of both valves were noted in 30, 18 and 10% of patients, respectively. After 12 months of PD regimen, 20% patients had aortic, 24% mitral and 8% had calcification of both valves. After one year of PD, LVH was 62 and 36% in patients with and without CVC, respectively (p50.05). Endothelin-1 is an independent predictor of CVC at the baseline, while nitric oxide is inversely an independent predictor at the end of follow-up. Conclusions: CVC is associated with LVH in PD patients. These findings identified a potential role for monitored markers to be incorporated into therapeutic strategies aimed at detection and treatment of cardiovascular complications and prevention strategies.

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Is residual renal function and better phosphate control in peritoneal dialysis an answer for the lower prevalence of valve calcification compared to hemodialysis patients?

Cited by 32 publications

References 43 publications

Differences in Dental Calculus Indices and Salivary Calcium and Phosphate Levels in Children With Chronic Kidney Disease Undergoing Hemodialysis and Peritoneal Dialysis Therapy

Differences in Dental Calculus Indices and Salivary Calcium and Phosphate Levels in Children With Chronic Kidney Disease Undergoing Hemodialysis and Peritoneal Dialysis Therapy

Coronary Artery Calcification in Hemodialysis and Peritoneal Dialysis

Valvular calcification and left ventricular modifying in peritoneal dialysis patients

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