Is sclerosing hemangioma of lung an alveolar mixed tumour?

Immunohistochemical and ultrastructural markers suggest different origins for cuboidal and polygonal cells in pulmonary sclerosing hemangioma

“…It reported that ultrastructurally the tumor is comprised of a mixture of epithelial and mesenchymal elements in varying stages of differentiation, including type II pneumocytes and primitive mesenchymal cells. 13 Another potential explanation for disputation on SH histogenesis is tumor transdifferentiation as hypothesized by Zhang et al 14 SH cells may commit to particular specialization changes, which result in transition between neoplastic epithelia and neuroendocrine cells, between neoplastic epithelia and mesenchyme, as well as transition between nonneuroectodermal and neuroectodermal cells. In addition to clear morphological differences in the major SH cells, we also observed the transitional phenomenon between cuboidal cells and glandular cells.…”

Multiple sclerosing hemangioma of the right lung in a 23‑year‑old female patient: A case report and review of the literature

“…Pulmonary sclerosing hemangioma (PSH) is an uncommon benign tumor of the lungs, first reported by Liebow and Hubbell in 1956 (1). Its origin has been suggested to be vascular, mesothelial, mesenchymal, epithelial and neuroendocrine (1)(2)(3)(4)(5), but immunohistochemical examination suggests that PSH is derived from primitive respiratory epithelium. It primarily affects Asian women and the female: Male ratio is 5:1 (6,7).…”