Is selenium intake associated with the presence of depressive symptoms among US adults? Findings from National Health and Nutrition Examination Survey (NHANES) 2011–2014

Ghimire, Saruna; Baral, Binaya Kurmar; Du, Feng; Sy, Francisco S.; Rodríguez, R. M. García

doi:10.1016/j.nut.2018.12.007

Cited by 27 publications

(28 citation statements)

References 38 publications

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“…It should be noted that excessive selenium consumption also seems to be related to a higher risk of developing depression, corroborating the hypothesis of a U-association between these two variables ( 15 ). Considering that, among the evaluated farmers, no individual exceeded the intake above the UL established for selenium (400 μg/day), the evaluation of the effects of excessive consumption of this nutrient cannot be performed in this study.…”

Section: Discussionsupporting

confidence: 77%

“…In contrast, the results of two cross-sectional studies conducted among a geriatric population in rural China ( 7 ), as well as a population of patients on hemodialysis ( 49 ), found no significant association between selenium levels and depression scores after controlling for chronic kidney disease and cognitive function. Research with the American adult population also found no association between these variables ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

“…In rats, higher levels of selenium have been shown to be protective against the development of depressive symptoms in response to stress ( 13 ). Despite this, the evidence is still contradictory ( 9 – 11 , 14 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

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Association of Selenium Intake and Development of Depression in Brazilian Farmers

et al. 2021

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Introduction: Depression and deficiency in the consumption of micronutrients are a public health problem, especially in the rural population. The deficiency in selenium consumption affects mental health, contributing to the development of major depressive disorders. Thus, this study aimed to evaluate selenium intake and its association with depressive symptoms in farmers in southeastern Brazil.Material and Methods: Epidemiological, cross-sectional, and analytical study with 736 farmers aged between 18 and 59. A semistructured questionnaire was used to collect sociodemographic, lifestyle and clinical condition data. For evaluation of food intake, three 24-h recalls were applied, and for identification of depressive episodes, the Mini-International Neuropsychiatric Interview was conducted.Results: A total of 16.1% (n = 119) of the farmers presented symptoms of major depressive episodes, 5.8% (n = 43) presented symptoms of current depressive episodes, and 10.3% (n = 76) presented symptoms of recurrent major depressive episodes. Sociodemographic factors associated with depression were gender (p < 0.001), marital status (p = 0.004), and socioeconomic class (p = 0.015). The consumption of high doses of selenium was associated with a reduction of ~54% in the chances of occurrence of depression (OR = 0.461; 95% CI = 0.236–0.901).Conclusion: High selenium intake is associated with a lower prevalence of depression even after adjusting for sociodemographic variables, lifestyle, and pesticide intoxication. The findings of this study contributed to highlighting the high prevalence of depression in rural areas and its relationship with selenium intake.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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Association of Selenium Intake and Development of Depression in Brazilian Farmers

et al. 2021

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“…1b). This indicated these grapes were very low in selenium and lithium contents, in consideration of the recommended dietary allowance of 55 μg day −1 for selenium (Ghimire et al ., 2019) and dietary intake of 0.6 to 3.1 mg day −1 for lithium (Schrauzer, 2002). Overall, Edelweiss (#2) had the richest selenium and lithium content in skin and juice, except that, there was no significant difference ( P < 0.05) among these cultivars.…”

Section: Resultsmentioning

confidence: 99%

Biofortification with selenium and lithium improves nutraceutical properties of major winery grapes in the Midwestern United States

Zhao

Xie

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et al. 2020

Int J of Food Sci Tech

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“…According to data published by the World Health Organization, the prevalence of depression worldwide is about 3% [24], and the prevalence of depression in patients with papillary thyroid cancer is as high as 30% [25]. A retrospective study by British scholars found that major depression may increase the incidence of thyroid disease [26].…”

Section: Papillary Thyroid Carcinoma and Serotonin Transporter Genementioning

confidence: 99%

Progress in Research on 5-HTTLPR under Stress and Thyroid Papillary Carcinoma

Luo¹,

Guo²,

Chen³

et al. 2019

JBBS

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The central nervous system plays an important role in regulating thyroid hormone homeostasis. 5-HT is one of the important neurotransmitters involved in energy balance regulation. 5-HT transporters affect 5-HT function by regulating SERT protein expression and transcriptional activity. Based on the biological correlation between thyroid hormone and thyroid tumors, 5-HTTLPR is associated with thyroid tumors under stress. Animal models of thyroid disease have shown that some of the transmitters in the brain's monoaminergic nervous system have changed, and when the monoamine transporter gene expression is altered, it is found that this disorder is more pronounced. This article discusses whether thyroid papillary carcinoma patients are associated with 5-HTTLPR and whether the mechanism of thyroid papillary carcinoma "gene x environment" has an effect. Briefly describe the role of 5-HTTLPR in the development of patients with papillary thyroid carcinoma, and provide a basis for clinical diagnosis and treatment of papillary thyroid cancer.

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Is selenium intake associated with the presence of depressive symptoms among US adults? Findings from National Health and Nutrition Examination Survey (NHANES) 2011–2014

Cited by 27 publications

References 38 publications

Association of Selenium Intake and Development of Depression in Brazilian Farmers

Association of Selenium Intake and Development of Depression in Brazilian Farmers

Biofortification with selenium and lithium improves nutraceutical properties of major winery grapes in the Midwestern United States

Progress in Research on 5-HTTLPR under Stress and Thyroid Papillary Carcinoma

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