Is serum albumin a good marker for malnutrition in the physically impaired elderly?

Kuzuya, Masafumi; Izawa, Sachiko; Enoki, Hiromi; Okada, K.; Iguchi, Akihisa

doi:10.1016/j.clnu.2006.07.009

Cited by 124 publications

(92 citation statements)

References 25 publications

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“…In contrast, decreased physical activity is reported to decrease serum albumin in the elderly (Kumagai et al 2005). Furthermore, Kuzuya et al (2007) suggested that impaired physical function reduced serum albumin concentration. Although causality remains unclear, ADL and serum albumin levels are considered to be closely associated with each other in relation to mortality.…”

Section: Discussionmentioning

confidence: 99%

“…Serum albumin is not only an indicator of nutritional risk, but also of inflammation. Hypoalbuminemia is suggested to result from the combined effects of inflammation and inadequate protein and caloric intake in patients with chronic disease (Don and Kaysen 2004;Kuzuya et al 2007). We did not measure inflammation markers and were unable to determine interrelationships between serum albumin and inflammation.…”

Section: Discussionmentioning

confidence: 99%

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Low Body Mass Index and Low Serum Albumin Are Predictive Factors for Short-Term Mortality in Elderly Japanese Requiring Home Care

Kitamura

Nakamura

Nishiwaki

et al. 2010

Tohoku J. Exp. Med.

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Japan has a rapidly growing elderly population. The proportion of citizens aged 65 years and over was 22.1% in 2008, and is projected to as high as 27% by 2015 (Health and Welfare Statistics Association 2009). In accordance, elderly individuals requiring care are also increasing. To cope with this situation, the long term care service system was implemented in Japan in 2000. Since then, the number of elderly requiring care doubled from 2.2 to 4.4 million (Health and Welfare Statistics Association 2008).One of the important challenges for people requiring care is how to prevent a decrease in activities of daily living (ADL). To address this issue, we initiated the Yamato Study, a population-based study of individuals utilizing the long term care service system, to develop preventive methods for diminishing ADL levels (Nishiwaki et al. 2005(Nishiwaki et al. , 2007.Another critical risk for people requiring care is increased mortality. Kuzuya et al. (2006) demonstrated that decreased ADL is associated with higher mortality rates while Takeda (2004) showed that higher requisite care levels are associated with higher mortality rates. These studies suggest that ADL level is an important predictor of mortality in elderly requiring care. A number of studies targeting independent elderly people in the community have also indicated that body stature (Grabowski and Ellis 2001;Al Snih et al. 2007), muscle strength (Al Snih et al. 2002), and serum albumin levels (Sahyoun et al. 1996;Okamura et al. 2008) are significant predictors of mortality. To date, however, only a few studies have explored risk factors for mortality other than ADL in elderly people requiring care to date (Enoki et al. 2007a(Enoki et al. , 2007b. This study aimed to clarify multiple risk factors for two-year mortality through follow-up of the Yamato Study elderly cohort who utilize the long term care service system.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Low Body Mass Index and Low Serum Albumin Are Predictive Factors for Short-Term Mortality in Elderly Japanese Requiring Home Care

Kitamura

Nakamura

Nishiwaki

et al. 2010

Tohoku J. Exp. Med.

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“…In addition, its value is limited by the long half-life (14-20 days), hydration, posture, hepatic and renal impairment, and possibly ageing itself (Omran and Morley, 2000b). The usage of serum albumin levels in frail elderly even without inflammation has been questioned (Kuzuya et al, 2007). Nevertheless, it has considerable prognostic impact (Phillips et al, 1989;Ferguson et al, 1993;Corti et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Comparison of two malnutrition risk screening methods (MNA and NRS 2002) and their association with markers of protein malnutrition in geriatric hospitalized patients

et al. 2010

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Background: Malnutrition occurs frequently in the elderly and is associated with increased morbidity and mortality. The mininutritional assessment (MNA) has been used most frequently in the geriatric literature. The nutritional risk screening 2002 (NRS) has been proposed as universal screening method for hospitalized patients. The aim of our study was to compare both tools as they are correlated with protein malnutrition. Methods: MNA, NRS, and markers of protein malnutrition were measured in 104 consecutive inpatients admitted to an acute geriatric ward. Results: The median age was 84 years (IQR: 78-89), 81 were females. The median body mass index was 23.1 kg/m 2 (IQR: 20-27.3), the median upper-arm and calf circumferences were 25 cm (IQR: 23-29) and 33 cm (IQR: 29-36). According to MNA, 23 patients were malnourished, 50 at risk of malnutrition, and 31 had a normal nutritional status. The NRS indicated that 35 were at moderate to severe risk of malnutrition and 69 at low risk. Serum prealbumin and retinol-binding protein concentrations were inversely associated with the severity of malnutrition as indicated by the NRS (P ¼ 0.06 and o0.01, respectively), whereas the MNA was not associated with these serum proteins. After adjustment for C-reactive protein and creatinine clearance, only retinol-binding protein concentrations were consistently associated with both malnutrition scores. Conclusions: The NRS seems to be superior compared with the MNA and serum proteins in identifying elderly patients at risk of malnutrition during acute intercurrent illness.

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“…Although malnutrition has been associated with increased hospitalization, increased susceptibility to infection, reduced QOL, and increased mortality [49][50][51], nutritional status evaluation may not be afforded sufficient attention in the field of chemotherapy-induced toxicity in patients with NSCLC, who themselves represent a considerable risk factor for complications and co-morbidities. Albumin is habitually included among parameters utilized for nutritional assessment and has recently become more widespread [52].…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Chemotherapy-induced Alopecia Treated with Bojungikki-tang

Lee¹

2017

J Int Korean Med

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Background: A frequent manifestation of advanced NSCLC is malnutrition, even though there are many studies which relate it with a poor survival, its relation with toxicity has not yet been consistently reported. The aim of this study was to associate malnutrition and albumin serum levels with the occurrence of chemotherapy-induced toxicity in cisplatin plus paclitaxel chemotherapy-treated NSCLC. Methods: We prospectively evaluated 100 stage IV NSCLC patients treated with paclitaxel (175 mg/m

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Is serum albumin a good marker for malnutrition in the physically impaired elderly?

Cited by 124 publications

References 25 publications

Low Body Mass Index and Low Serum Albumin Are Predictive Factors for Short-Term Mortality in Elderly Japanese Requiring Home Care

Low Body Mass Index and Low Serum Albumin Are Predictive Factors for Short-Term Mortality in Elderly Japanese Requiring Home Care

Comparison of two malnutrition risk screening methods (MNA and NRS 2002) and their association with markers of protein malnutrition in geriatric hospitalized patients

A Case Report of Chemotherapy-induced Alopecia Treated with Bojungikki-tang

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