Is serum brain-derived neurotrophic factor related to craving for or use of alcohol, cocaine, or methamphetamine?

Hilburn, Craig; Nejtek, Vicki A.; Underwood, Wendy; Singh, Meharvan; Patel, Gauravkumar; Gangwani, Pooja; Forster, Michael J.

doi:10.2147/ndt.s18953

Cited by 13 publications

(11 citation statements)

References 35 publications

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“…These results indicate cocaine and methamphetamine users respond similarly to individual craving items. The significantly higher latent mean for the methamphetamine group supports earlier work (Hilburn, et al, 2011) that this group experiences more intense craving. Latent mean differences are commonly found and still allow meaningful group comparisons.…”

Section: Discussionsupporting

confidence: 83%

“…Despite possible differences in how craving is experienced by cocaine- and methamphetamine-dependent individuals (e.g., Hilburn et al, 2011), research often assumes the construct is measured equivalently (e.g., factor loadings are invariant). Measurement invariance exists when item content has the same meaning across groups, which allows score comparison.…”

Section: Introductionmentioning

confidence: 99%

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On the invariance of the Stimulant Craving Questionnaire (STCQ) across cocaine and methamphetamine users

Northrup¹,

Green²,

Walker³

et al. 2015

Addictive Behaviors

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Background The rapid rise in the number of methamphetamine users, relative to cocaine users, has brought the number of each to nearly equal levels, making research on similarities and differences across these groups a needed area of exploration. Craving is postulated to play a significant role in relapse for both user types, yet group differences on observed scale scores have been reported without first assessing the prerequisite measurement equivalence (invariance) of the items, which is essential for meaningful group comparisons. Methods/design Baseline data from stimulant users in residential treatment (N=301; n=177 cocaine; n=124 methamphetamine) were used to assess the measurement invariance of the 10-item Stimulant Craving Questionnaire (STCQ), which was adapted from a cocaine-specific measure. Results The unifactorial STCQ demonstrated measurement invariance across cocaine and methamphetamine users for factor loadings (metric), common residual covariances between item pairs, and item intercepts (scalar), as determined by fit indices (RMSEA<0.05; CFI & TLI>0.95; SRMR<0.10). The latent mean, as well as 5 (out of 10) item means and the overall composite scale score, were significantly greater for methamphetamine users compared to cocaine users. Discussion Results indicate the STCQ is an invariant tool for the assessment of stimulant craving across the two most prevalent user types. Methamphetamine users had significantly higher levels of observed and latent craving than cocaine users, demonstrating a potentially meaningful difference in craving between users of these two stimulants. Future research will determine if treatments and statistical models need to account for craving variations across methamphetamine and cocaine users.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

On the invariance of the Stimulant Craving Questionnaire (STCQ) across cocaine and methamphetamine users

Northrup¹,

Green²,

Walker³

et al. 2015

Addictive Behaviors

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“…However, in the current study, female rats that self-administered METH did not have changes in BDNF levels. Of clinical relevance, male recently abstinent human psychostimulant users (cocaine or METH users) had higher serum BDNF levels than females when the number of abstinence days was controlled for (Hilburn et al, 2011). Further, recently abstinent female METH users but not males had decreased hippocampal volumes compared to sex-matched controls (Du et al, 2015).…”

Section: 0 Discussionmentioning

confidence: 99%

The neurochemical consequences of methamphetamine self-administration in male and female rats

Johansen

McFadden

2017

Drug and Alcohol Dependence

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Background Methamphetamine (METH) is an addictive substance that is used in both males and females. Few preclinical studies have focused on understanding sex-differences in the neurochemical consequences of contingent METH. The purpose of the current study was to investigate potential sex-differences in the neurochemical consequences of METH self-administration. Methods Male and female adult rats were given extended access to METH or saline self-administration for 7 d. Following self-administration, hippocampal brain-derived neurotrophic factor (BDNF) and striatal dopamine transporter (DAT) were assessed via western blotting. Results Male and female rats had similar METH intake. METH self-administration reduced striatal DAT in both sexes, but only males that self-administered METH had elevated hippocampal BDNF levels. Conclusions Sex-differences exist in the neurochemical consequences of METH self-administration. These differences may lead to sex-specific vulnerability to the toxic effects of METH.

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“…Similarly, human METH users often have elevated blood serum levels of BDNF (Kim et al, 2005). Of note, BDNF levels decreased with prolonged abstinence in human psychostimulant users (Hilburn et al, 2011). These findings suggest that BDNF may play a role in the neurochemical changes following METH use.…”

Section: Introductionmentioning

confidence: 99%

Methamphetamine self-administration attenuates hippocampal serotonergic deficits: role of brain-derived neurotrophic factor

McFadden

Vieira-Brock

Hanson

et al. 2014

Int. J. Neuropsychopharm.

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Preclinical studies suggest that prior treatment with escalating doses of methamphetamine (METH) attenuates the persistent deficits in hippocampal serotonin (5-hydroxytryptamine; 5HT) transporter (SERT) function resulting from a subsequent “binge” METH exposure. Previous work also demonstrates that brain derived neurotrophic factor (BDNF) exposure increases SERT function. The current study investigated changes in hippocampal BDNF protein and SERT function in rats exposed to saline or METH self-administration prior to a binge exposure to METH or saline. Results revealed that METH self-administration increased hippocampal mature BDNF (mBDNF) immunoreactivity compared to saline-treated rats as assessed 24 h after the start of the last session. Further, mBDNF immunoreactivity was increased and SERT function was not altered at this timepoint in rats that self-administered METH prior to the binge METH exposure. These results suggest that prior exposure to contingent METH increases hippocampal mBDNF, and this may contribute to attenuated deficits in SERT function.

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Is serum brain-derived neurotrophic factor related to craving for or use of alcohol, cocaine, or methamphetamine?

Cited by 13 publications

References 35 publications

On the invariance of the Stimulant Craving Questionnaire (STCQ) across cocaine and methamphetamine users

On the invariance of the Stimulant Craving Questionnaire (STCQ) across cocaine and methamphetamine users

The neurochemical consequences of methamphetamine self-administration in male and female rats

Methamphetamine self-administration attenuates hippocampal serotonergic deficits: role of brain-derived neurotrophic factor

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