Is Sex an Independent Prognostic Factor in Esthesioneuroblastoma?

Stokes, William A; Camilon, P. Ryan; Banglawala, Sarfaraz M.; Nguyen, Shaun A.; Harvey, Richard J.; Vandergrift, William A.; Schlosser, Rodney J.

doi:10.2500/ajra.2015.29.4204

Cited by 13 publications

(8 citation statements)

References 19 publications

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“…CRC is one of the most common cancers all over the world (1). There are many differences between males and females in morbidity, mortality, prognosis, and biological behaviour for most cancers (19)(20)(21)(22)(23)(24). The sex differences in cancer survival have attracted great attention because they may be a signal of basic biological differences between males and females in cancer pathogenesis and treatment response, which can be incorporated into management strategies (25,26).…”

Section: Discussionmentioning

confidence: 99%

The predictive and prognostic value of sex in localized colorectal cancer: a SEER-based analysis

Ma¹,

Li²,

Meng³

2021

Transl Cancer Res TCR

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Background: Although the influence of sex on different cancer survival has been investigated, the predictive and prognostic value of sex in localized colorectal cancer (CRC) still remain controversial.Methods: Survival was evaluated in patients who diagnosed with localized CRC in the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2016. Overall survival (OS) outcomes were estimated with the Kaplan-Meier method, and multivariable Cox regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).Results: We obtained a dataset that included 70,836 males and 69,705 females of localized CRC patients.Compared with males, females more often had age ≥75 years (55.1% vs. 44%), right-sided colon cancer (56.8% vs. 45.4%), and more advanced pT stage cancer (75.5% vs. 72%). In addition, we found that females had better OS than males and that sex could be an independent factor of OS in T1-3N0M0 (Stage I-II) colon cancer (regardless of right/left-sided tumour) and T1-2N0M0 (Stage I) rectal cancer (each HR <1, each P<0.05). Although a significant OS benefit was not observed in T3N0M0 rectal cancer in the overall analysis (P=0.183), females who underwent postoperative chemotherapy had better OS than males among T3N0M0 (Stage II) rectal cancer patients significantly (P<0.001).Conclusions: In our study, sex was shown to be a prognostic factor in localized-CRC. In particular, females may benefit more from postoperative chemotherapy than males with T3N0M0 (Stage II) rectal cancer.

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Section: Discussionmentioning

confidence: 99%

The predictive and prognostic value of sex in localized colorectal cancer: a SEER-based analysis

Ma¹,

Li²,

Meng³

2021

Transl Cancer Res TCR

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“…The nomogram is a new form of disease risk estimation that can aid clinical decision making (Botticelli et al, 2019). Studies based on the Surveillance, Epidemiology, and End Results Program (SEER) database showed that gender had no significant difference in the OS of neuroblastoma in children (Stokes et al, 2015). These results were consistent with our findings.…”

Section: Discussionmentioning

confidence: 99%

A prognostic nomogram for neuroblastoma in children

Meng

2019

PeerJ

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Introduction Neuroblastoma is one of the most common extracranial solid tumors in children, which accounts for about 7–10% in children’s tumors. The prognosis group of patients with neuroblastoma could not only improve the efficacy of high-risk patients, but also reduce the effects of drug complications for surviving patients. Material and Methods Patients diagnosed with neuroblastoma between 1986 and 2012 were selected form the TARGET database. The nomogram was built with potential risk factors based on COX regression analysis. The precision of the 3-year and 5-year survival of the nomograms was evaluated by the area under receiver operating characteristic (ROC) curve (AUC). Results A total of 757 child neuroblastoma patients were selected from the TARGET database. Univariate analysis showed that age of diagnosis (>520 day), race of American Indian or Alaska Native, stage 4 in International Neuroblastoma Staging System (INSS), MYCN status, DNA ploidy, and high mitosis-karyorrhexis index were associated with overall survival (OS). Multivariate analysis showed age of diagnosis (>520 day), stage 4 in INSS and DNA ploidy were independent risk factors of OS. The concordance index (C-index) of the nomogram was 0.704 (95% CI [0.686–0.722]) in the training cohort while the C-index in the validation cohort was 0.672 (95% CI [0.644–0.700]). AUC values of ROC curves for 3-year OS and 5-year OS in the training cohort were 0.732 and 0.772, respectively. The nomogram performed better compared with INSS staging system, tumor histology and children’s oncology group (COG) risk group with C-indexes of 0.662 (95% CI [0.648–0.676]), 0.637 (95% CI [0.622–0.652]) and 0.651 (95% CI [0.637–0.665]), respectively. Conclusions The nomogram showed stronger predictive power than the INSS staging system, tumor histology and COG risk group. Precise estimates of the prognosis of childhood neuroblastoma might help doctors make better treatment decisions.

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“…Identifying patients at risk of poor outcome can potentially help to guide the need for adjuvant treatment. These studies have found improved survival with age less than 60 years, female sex, having private health insurance, lower tumor grade, lower Kadish stage, N0 neck status, and margin‐negative resection . Furthermore, male patients were found to present with higher‐grade disease and a trend toward higher stage .…”

Section: Sinonasal Malignanciesmentioning

confidence: 96%

ICAR: endoscopic skull‐base surgery

Wang

Zanation

Gardner

et al. 2019

Int Forum Allergy Rhinol

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157

279

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Background Endoscopic skull‐base surgery (ESBS) is employed in the management of diverse skull‐base pathologies. Paralleling the increased utilization of ESBS, the literature in this field has expanded rapidly. However, the rarity of these diseases, the inherent challenges of surgical studies, and the continued learning curve in ESBS have resulted in significant variability in the quality of the literature. To consolidate and critically appraise the available literature, experts in skull‐base surgery have produced the International Consensus Statement on Endoscopic Skull‐Base Surgery (ICAR:ESBS). Methods Using previously described methodology, topics spanning the breadth of ESBS were identified and assigned a literature review, evidence‐based review or evidence‐based review with recommendations format. Subsequently, each topic was written and then reviewed by skull‐base surgeons in both neurosurgery and otolaryngology. Following this iterative review process, the ICAR:ESBS document was synthesized and reviewed by all authors for consensus. Results The ICAR:ESBS document addresses the role of ESBS in primary cerebrospinal fluid (CSF) rhinorrhea, intradural tumors, benign skull‐base and orbital pathology, sinonasal malignancies, and clival lesions. Additionally, specific challenges in ESBS including endoscopic reconstruction and complication management were evaluated. Conclusion A critical review of the literature in ESBS demonstrates at least the equivalency of ESBS with alternative approaches in pathologies such as CSF rhinorrhea and pituitary adenoma as well as improved reconstructive techniques in reducing CSF leaks. Evidence‐based recommendations are limited in other pathologies and these significant knowledge gaps call upon the skull‐base community to embrace these opportunities and collaboratively address these shortcomings.

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Is Sex an Independent Prognostic Factor in Esthesioneuroblastoma?

Cited by 13 publications

References 19 publications

The predictive and prognostic value of sex in localized colorectal cancer: a SEER-based analysis

The predictive and prognostic value of sex in localized colorectal cancer: a SEER-based analysis

A prognostic nomogram for neuroblastoma in children

ICAR: endoscopic skull‐base surgery

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