Is Shock-Induced Lung Fibrosis Reversible? A Report on Recovery from „Shock-Lung”

Mittermayer, Ch.; J, Hassenstein; Riede, U. N.

doi:10.1016/s0344-0338(78)80131-9

Cited by 23 publications

(8 citation statements)

References 7 publications

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“…There seems to be some evidence for this in a single case report, with sequential morphological analysis, of a patient who survived acute post-traumatic pulmonary fibrosis. 32 In this instance the newly synthesised and only loosely cross linked collagen (with its increased solubility properties) may be removed more readily by degrading enzymes. On the other hand, in ongoing chronic pulmonary fibrosis recurrent "injuries" to the lung tissue may be assumed to result in a progressive and irreversible process.…”

Section: Discussionmentioning

confidence: 99%

Pattern of collagen types and molecular structure of collagen in acute post-traumatic pulmonary fibrosis.

Nerlich

Müller

1987

Thorax

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Analyses of collagen types and their amino acid structures have been made with lungs obtained from eight patients who died from the adult respiratory distress syndrome after nonpulmonary trauma. Collagen in lungs from patients with the adult respiratory distress syndrome was twice as soluble as that in control lungs (p < 0 01). The proportion of type III collagen in the whole organ as well as in the pepsin solubilised fraction was slightly but significantly raised (net increase of about 5-10% type III collagen (p < 0 05)). Both type I and type III collagen from the patients contained less hydroxylysine than collagen from control lungs. The alterations in tissue composition described here and observed in normal wound healing support the notion that acute post-traumatic pulmonary fibrosis resembles a wound healing process in the lungs.

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Section: Discussionmentioning

confidence: 99%

Pattern of collagen types and molecular structure of collagen in acute post-traumatic pulmonary fibrosis.

Nerlich

Müller

1987

Thorax

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“…A systemic reaction of connective tissue leading to fibrosis can be observed in protracted shock of man and animals [2,3,11,12,17,18,211. The initiating factors are not known.…”

Section: Discussionmentioning

confidence: 99%

Mesangium in Rats after E. coli Neurotoxin Shock: A Morphometric and Light Microscopic Analysis

Queisser

Drommer

1982

Vet Pathol

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Abstract. The renal corpuscles of 28 specific-pathogen-free Wistar rats fixed by perfusion were examined light microscopically and morphometrically following experimental protracted neurotoxin shock. The mean diameter of the center sections of 420 renal corpuscles was 1 13.0 pm. The mesangial portion occupied 9.5% of the total area of the renal corpuscle in control rats and increased to a maximum of 17.25% in experimental rats. The number of mesangial nuclei per renal corpuscle in rats with protracted shock showed that expansion of the mesangium with compression of capillary loops was not caused solely by an increase in the number of cells. Furthermore, there was an enlargement of the mesangial cytoplasm and matrix. Activation and proliferation of connective tissue in rats with protracted shock could be observed in the interstitium of various organs as well as in the mesangium of the glomerulus.Many publications exist on shock [l, lo], however, little attention has been given to an increase in the mesangium of the glomerulus of the kidney following shock. Morphometric data of mesangial changes after protracted neurotoxin shock in pigs are available [2, 41. Several authors show that in protracted shock a reaction of connective tissue in various organs can be detected [3,18, 221. This study will clarify the reaction of the mesangium as mesenchymal tissue in the rat in long-lasting shock situations. This investigation assesses various parameters of the renal corpuscle of the rat by a quantitative-morphologic method. The rats in this experiment were submitted to various shock intensities and duration by the application of one to four Escherichiu coZi neurotoxin injections. As parameters for a possible mesangial reaction, we determined the area of the glomerulus capsule, the corresponding mesangial area, and the number of mesangial nuclei. In addition to normal values in the rat, we intended to ascertain possible changes in the mesangium. As an alternative to the point-counting method, a simpler, more direct, and thereby faster technique for morphometric evaluations of the glomerulus was used. Materials and MethodsTwenty-eight specific-pathogen-free Wistar rats (13 male, 15 female) were analyzed. Eight of them comprised the control group. The initial body weight of the 55-to 74-day-old rats was between 156 and 218 g. The rats were kept in separate metabolism cages and fed a commercial

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“…Septic shock plays an important role not only in man, but also in animals. As known from shock patients (15,16,20,21) and from animal experiments (4, 9, 23), the protracted shock leads to a severe interstitial cell infiltration and after some weeks to focal fibrosis in various organs. The glomeruli show distinct alterations (17, 18) but these findings have mostly been described by light microscopy only, or they have dealt with changes during the early stages of shock (14).…”

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confidence: 90%

“…Alteraciones glomerulares ultraestructurales en choques neurotoxinicos inducidos experimentalmente en ratas Se indujo un choque en 37 ratas Wistar SPF-Han mediante inyecciones endovenosas de neurotoxina d e E. coli. 16 animales testigos recibieron soluci6n salina fisiol6gica. Las lesiones glomerulares m i s importantes se mostraron en el mesangio y en las celulas epiteliales viscerales y eran menos marcadas que las modificaciones intersticiales tras el choque neurotoxinico.…”

Section: Introductionunclassified

Ultrastructural glomerular alterations in experimentally induced neurotoxin shock in rats

Martin

Drommer

Kaup

1984

Zentralblatt für Veterinärmedizin Reihe B

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Summary Shock was induced in 37 SPF‐Han Wistar rats by intravenous injections of E. coli neurotoxin; 16 control animals received physiological saline solution. The main glomerular lesions were present in the mesangium and the visceral epithelial cells and were less pronounced than the interstitial alterations after neurotoxin shock. The mesangial lesions appear to be similar to those in chronic interstitial nephritis in dogs and the visceral epithelial cells show comparable alterations to those, for example, in acute renal failure in man and acute hog cholera in swine. Zusammenfassung Ultrastrukturelle glomeruläre Veränderungen bei einem experimentell induzierten Neurotoxinschock an Ratten Ein Schock wurde bei 37 SPF‐Han Wistar Ratten durch intravenöse Injektionen von E. coli Neurotoxin induziert. 16 Kontrolltiere erhielten physiologische Kochsalzlösung. Die wichtigsten glomerulären Schädigungen zeigten sich im Mesangium und in den viszeralen Epithelzellen und waren weniger ausgeprägt als die interstitiellen Veränderungen nach Neurotoxinschock. Die mesangialen Schädigungen schienen ähnlich denjenigen einer chronischen interstitiellen Nephritis bei Hunden, und die viszeralen Epithelzellen zeigten Veränderungen, wie beim akuten Nierenversagen des Menschen und akuter Schweinepest. Résumé Lésions ultrastructurelles glomérulaires lors d'un choc neurotoxique induit expérimentalement chez des rats Un choc a été induit par des injections intraveineuses de neurotoxine de E. coli chez 37 rats SPF‐Han Wistar. 16 animaux de contrôle ont reçu une solution physiologique. Les principales lésions glomérulaires se sont manifestées dans le Mesangium et dans les cellules épithéliales viscérales et furent moins étendues que les lésions interstitielles après un choc dû à une néphrite interstitielle chronique chez des chiens et les cellules épithéliales viscérales présentèrent des lésions comparables par exemple à celles rencontrées lors d'un blocage rénal aigu chez l'être humain et d'une peste porcine aiguë. Resumen Alteraciones glomerulares ultraestructurales en choques neurotoxínicos inducidos experimentalmente en ratas Se indujo un choque en 37 ratas Wistar SPF‐Han mediante inyecciones endovenosas de neurotoxina de E. coli. 16 animales testigos recibieron solución salina fisiológica. Las lesiones glomerulares más importantes se mostraron en el mesangio y en las células epiteliales viscerales y eran menos marcadas que las modificaciones intersticiales tras el choque neurotoxínico. Las lesions mesangiales se asemejaban a las de una nefritis intersticial crónica en perros, y las células epiteliales viscerales ostentaban modificaciones comparables, por ej. con la insuficiencia renal aguda en el ser humano y con la peste porcina aguda.

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Is Shock-Induced Lung Fibrosis Reversible? A Report on Recovery from „Shock-Lung”

Cited by 23 publications

References 7 publications

Pattern of collagen types and molecular structure of collagen in acute post-traumatic pulmonary fibrosis.

Pattern of collagen types and molecular structure of collagen in acute post-traumatic pulmonary fibrosis.

Mesangium in Rats after E. coli Neurotoxin Shock: A Morphometric and Light Microscopic Analysis

Ultrastructural glomerular alterations in experimentally induced neurotoxin shock in rats

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