Is the Adrenergic Control of Renin Release Dominant in Man?

Davies, R.; Slater, J. D. H.

doi:10.1016/s0140-6736(76)90665-6

Cited by 35 publications

(14 citation statements)

References 19 publications

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“…We have recently shown that isosmolar hypovolemia achieved by an 850 head-up tilt provokes the release of both renin and vasopressin in normal subjects (10), and we have also shown that renin release provoked in this way can be abolished by intravenous propranolol administered just before tilt (12). It is to the question of the possible role of renin in promoting vasopressin release that this present study is addressed, for if indeed the release of vasopressin which follows orthostasis is stimulated by renin, then propranolol should abolish the response of both of these hormones.…”

Section: Introductionmentioning

confidence: 86%

The interrelationship between the release of renin and vasopressin as defined by orthostasis and propranolol.

Davies¹,

Forsling²,

Slater³

1977

J. Clin. Invest.

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A B S T R A C T The concentration of both plasma renin and plasma arginine vasopressin rose in normal subjects after an 850 head-up tilt. Plasma renin activity, which increased 70-80% above the supine value, was maximal at 15 or 30 min, whereas the six-to sevenfold increase of plasma arginine vasopressin concentration was observed between 30 and 45 min. Intravenous propranolol administered just before tilt was used to investigate the possibility that the delayed rise of arginine vasopressin was stimulated by renin. Although the response of plasma renin was completely abolished by propranolol, the response of vasopressin was unaffected. These findings suggest that the release of vasopressin that follows isosmolar hypovolemia achieved by orthostasis may occur independently of changes in the renin-angiotensin system in the presence of propranolol.

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Section: Introductionmentioning

confidence: 86%

The interrelationship between the release of renin and vasopressin as defined by orthostasis and propranolol.

Davies¹,

Forsling²,

Slater³

1977

J. Clin. Invest.

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“…We report a detailed study of its haemodynamic effects during exercise and passive tilting in six healthy young men. Measurements were also made of plasma renin activity before and during passive tilting, since the latter is known to stimulate renin release by a /-adrenergic mechanism (Davies & Slater, 1976;Cunningham et al, 1981). Measurements were continued for 24 h after a single oral dose of the drug, in order to assess its duration of action.…”

Section: Introductionmentioning

confidence: 99%

Bopindolol: a new long acting beta‐receptor antagonist; its effects on haemodynamics, and on the renin response to tilting.

Turner¹,

Fj²,

Knight³

et al. 1984

Brit J Clinical Pharma

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1Oral administration of single doses of bopindolol (1-4mg) caused significant reductions in the rises of systolic blood pressure and heart rate produced by exercise; only the reduction in the rise of heart rate was significantly dose-related. 2 Resting heart rate was reduced by bopindolol. There were small effects on resting blood pressure. 3 Bopindolol caused a significant attenuation of the rise in plasma renin activity produced by passive head-up tilting to 75-85 degrees. 4 Bopindolol produced a dose-related attenuation of the increase in pulse rate evoked by passive tilting. 5 All effects 1-4 were maintained for at least 24 h. 6 There was no measurable effect on plasma potassium concentration, peak flow rate or forced expiratory volume (FEV,).

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“…Renin release provoked by orthostasis and by isoprenaline infusion is mediated by activation of intrarenal P-adrenoceptors (Inoue, 1973;Sabto, Grunfeld & Moreau, 1975;Davies & Slater, 1976) and we have shown that an 850 tilt (Davies & Slater, 1976) and a low-dose isoprenaline infusion (Davies, Slater, Rudolf & Geddes, 1977) both give a highly reproducible and graded response in normal subjects. To characterize the adrenoceptor which mediates renin release, we have recently compared the effect of intravenous isoprenaline and salbutamol on plasma renin activity (PRA) in doses which produce similar haemodynamic effects (Davies, Geddes, Slater, Wiggins & Payne, 1975;Davies, Wiggins, Slater & Geddes, 1977).…”

Section: Introductionmentioning

confidence: 59%

“…To characterize the adrenoceptor which mediates renin release, we have recently compared the effect of intravenous isoprenaline and salbutamol on plasma renin activity (PRA) in doses which produce similar haemodynamic effects (Davies, Geddes, Slater, Wiggins & Payne, 1975;Davies, Wiggins, Slater & Geddes, 1977). Although in the dose-ratio of isoprenaline to salbutamol 1 to 10, comparable agonist effects were seen when judged haemodynamically, isoprenaline provoked a brisk, dose-related release of renin, whereas salbutamol was without effect.…”

Section: Introductionmentioning

confidence: 99%

The inhibiton of adrenergically provoked renin release by salbutamol in man.

Wiggins¹,

Davies²,

Başar³

et al. 1978

Brit J Clinical Pharma

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1 The /-adrenoceptor agonist salbutamol is shown to have antagonist properties by its effect on adrenergically provoked renin release in normal people. 2 It significantly reduces the rate of renin secretion provoked by either endogenous (85 0 head-up tilt) or exogenous (isoprenaline infusion) adrenergic stimulation. 3 Because renin is relatively simple to measure, and because in acute studies its release is relatively uninfluenced by the vagaries of direct and reflex cardiovascular effects, we suggest that, in the characterization of drugs which act on adrenergic f-receptors, an assessment of their effects on renin release would be useful.

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Is the Adrenergic Control of Renin Release Dominant in Man?

Cited by 35 publications

References 19 publications

The interrelationship between the release of renin and vasopressin as defined by orthostasis and propranolol.

The interrelationship between the release of renin and vasopressin as defined by orthostasis and propranolol.

Bopindolol: a new long acting beta‐receptor antagonist; its effects on haemodynamics, and on the renin response to tilting.

The inhibiton of adrenergically provoked renin release by salbutamol in man.

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