Is the C<sub>60</sub> Fullerene Molecule Toxic?!

Andrievsky, G. V.; Klochkov, Vladimir K.; Derevyanchenko, L. I.

doi:10.1080/15363830500237267

Cited by 186 publications

(119 citation statements)

References 26 publications

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“…This suggests that C6fl fullerene by itself does not exhibit any noticeable damaging effect on the cell membrane or nucleus under these experimental conditions. These results agree with the widespread opinion that pristine C6fl fuller ene is non-toxic (Andrievsky et al 2005).…”

Section: Individual Action Of the Drugssupporting

confidence: 83%

“…It has been shown previously that C6fl fullerene is able to penetrate through the cell membrane (Foley et al 2002;Prylutska et al 2012;Qiao et al 2007) and exhib its antioxidant properties (Prylutska et al 2008). Being non-toxic, at least at low concentrations (Andrievsky et al 2005;Aschberger et al 2010;Kolosnjaj et al 2007;Prylut ska et al 2007a), pristine C6fl fullerenes are able to suppress the growth of malignant tumors (Prylutska et al 2011a, b).…”

Section: Introductionmentioning

confidence: 99%

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Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules

et al. 2014

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C60 fullerenes are spherical molecules com posed purely of carbon atoms. They inspire a particularly strong scientific interest because of their specific physico chemical properties and potential medical and nanotech nological applications. In this work we are focusing on studying the influence of the pristine C60 fullerene on bio logical activity of some aromatic drug molecules in human buccal epithelial cells. Assessment of the heterochromatin structure in the cell nucleus as well as the barrier function of the cell membrane was performed. The methods of cell microelectrophoresis and atomic force microscopy were also applied. A concentration-dependent restoration of the functional activity of the cellular nucleus after exposure to DNA-binding drugs (doxorubicin, proflavine and ethidium bromide) has been observed in human buccal epithelial cells upon addition of C60 fullerene at a concentration of -1СГ5 M. The results were shown to follow the framework of interceptor/protector action theory, assuming that noncovalent complexation between C60 fullerene and the drugs (i.e., hetero-association) is the major process responsible for the observed biological effects. An independent con firmation of this hypothesis was obtained via investigation of the cellular response of buccal epithelium to the coad ministration of the aromatic drugs and caffeine, and it is based on the well-established role of hetero-association in drug-caffeine systems. The results indicate that C60 fuller ene may reverse the effects caused by the aromatic drugs, thereby pointing out the potential possibility of the use of aromatic drugs in combination with C60 fullerene for regu lation of their medico-biological action.

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Section: Individual Action Of the Drugssupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules

et al. 2014

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“…T he p u rity o f prepared C 60FA S sam ple (i.e., the presen ce/ absence o f any residual im purities, for exam ple carb o n black, toluene phase) is an im p o rta n t factor, w hich influ ences its toxicity (8,13). T he p u rity o f p repared C 60FA S sam ple w as determ ined by H P L C and G C /M S using stan d ard program s. Insoluble im purities were determ ined by u ltra-centrifugation.…”

Section: Chemical Analysis O F C60 Fullerene Aqueous Colloid Solutionmentioning

confidence: 99%

“…D ue to its nanom eter size, the pristine C60 fullerenes are able to interact w ith biom ole cules (3,4) an d penetrate th ro u g h the cell m em brane (5,6). They exhibit antioxidant properties (7) and, being non-toxic (at low concentration at least) (8)(9)(10)(11)(12)(13), exert specific health effects (e.g., suppress the grow th o f m alignant tum ors (14,15)). A lthough these molecules have extrem ely low w ater solubility (16), they form stable colloid solutions containing individual C60 fullerenes as well as C60 fullerene aggregates (clusters) in w ater (17,18), w hen subjected to extended m ix ing, sonication, or solvent exchange (19,20).…”

Section: Introductionmentioning

confidence: 99%

Structural Features of Highly Stable Reproducible C₆₀Fullerene Aqueous Colloid Solution Probed by Various Techniques

Ritter

Prylutskyy

Evstigneev

et al. 2014

Fullerenes, Nanotubes and Carbon Nanostructures

113

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“…Some reports indicate that pristine fullerenes are non-toxic, and that fullerene water systems have a wide spectrum of positive and unique biological activities [44] . For instance, there are studies showing that water-soluble fullerenes scavenge reactive oxygen species (ROS) in human skin cells [45] and that they are powerful antioxidants with no acute or sub-acute toxicity [46] .…”

Section: Introductionmentioning

confidence: 99%

Characterisation and determination of fullerenes: A critical review

Astefanei

Núñez

Galcerán

2015

Analytica Chimica Acta

169

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Highlights Methodologies for fullerene aggregate characterization are discussed.  Chromatographic and electrophoretic techniques for fullerene analysis are presented.  Accurate identification and detection of fullerenes by LC-MS is critically reviewed. Graphical abstract AbstractA prominent sector of nanotechnology is occupied by a class of carbon-based nanoparticles known as fullerenes. Fullerene particle size and shape impact in how easily these particles are transported into and throughout the environment and living tissues. Currently, there is a lack of adequate methodology for their size and shape characterisation, identification and quantitative detection in environmental and biological samples. The most commonly used methods for their size measurements (aggregation, size distribution, shape, etc.), the effect of sampling and sample treatment on these characteristics and the analytical methods proposed for their determination in complex matrices are discussed in this review. For the characterisation and analysis of fullerenes in real samples, different analytical techniques including microscopy, spectroscopy, flow field-flow fractionation, electrophoresis, light scattering, liquid chromatography and mass spectrometry have been reported. The existing limitations and knowledge gaps in the use of these techniques are discussed and the necessity to hyphenate complementary ones for the accurate characterisation, identification and quantitation of these nanoparticles is highlighted.

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Is the C₆₀ Fullerene Molecule Toxic?!

Cited by 186 publications

References 26 publications

Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules

Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules

Structural Features of Highly Stable Reproducible C₆₀Fullerene Aqueous Colloid Solution Probed by Various Techniques

Characterisation and determination of fullerenes: A critical review

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Is the C60 Fullerene Molecule Toxic?!

Cited by 186 publications

References 26 publications

Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules

Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules

Structural Features of Highly Stable Reproducible C60Fullerene Aqueous Colloid Solution Probed by Various Techniques

Characterisation and determination of fullerenes: A critical review

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Is the C₆₀ Fullerene Molecule Toxic?!

Structural Features of Highly Stable Reproducible C₆₀Fullerene Aqueous Colloid Solution Probed by Various Techniques