Is the mean platelet volume a predictive marker for the diagnosis of acute pyelonephritis in children?

Tekin, Mehmet; Konca, Çapan; Gülyüz, Abdulgani; Üçkardeş, Fatih; Turğut, Mehmet

doi:10.1007/s10157-014-1049-z

Cited by 34 publications

(46 citation statements)

References 21 publications

(20 reference statements)

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“…9 This is in accordance with Catal et al who demonstrated that the platelet counts were higher in patients with upper UTI and MPV values were higher in Gram-positive infections compared with Gram-negative infections. 10 He speculated that the rise in MPV in UTI can be caused by increased production of larger and /or younger platelets as a reaction to infection related platelet destruction, and increased level of beta-thromboglobulin in bacterial infection might activate and release platelet.…”

Section: Discussionsupporting

confidence: 82%

Platelet indices in children with urinary tract infection

Srinivasa

Dhingra

2018

Int J Contemp Pediatr

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Background: Urinary tract infection is one of the most common infection in children and may lead to serious morbidity like chronic pyelonephritis and renal scarring. Our hypothesis is that alteration of the platelet morphology can be a reliable index for early diagnosis and management of UTI without waiting for urine culture results. We try to demonstrate a link between the platelet indices and the type of organism, whether gram positive or gram negative to allow proper selection of the antibiotic regimen.Methods: It is a retrospective case control study where 35 urine culture proven cases and 35 cases of non UTI cases was taken as control. Children with haematological diseases affecting platelet were excluded. Platelet indices were taken including for MPV, PDW and platelet count and statistically analysed.Results: MPV and PDW were higher in patient with culture proven especially with gram positive organism.Conclusions: Although urine culture is considered as golden standard for diagnosis of urinary culture, it is time consuming. But early diagnosis can prevent renal parenchymal complications. Hence, we tried to find out other early, easy and sensitive method for detection of urinary tract infections in children. Platelet parameters (thrombocytosis, mean platelet volume, platelet distribution width) is available in analyser report of any complete blood count with no added value. It was also found that gram positive organism has higher mean platelet volume and platelet distribution width as compared to gram negative organism.

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Section: Discussionsupporting

confidence: 82%

Platelet indices in children with urinary tract infection

Srinivasa

Dhingra

2018

Int J Contemp Pediatr

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“…Tekin M investigated the MPV role in acute pyelonephritis (APN) and found that MPV is a fast, reliable standard that can adequately predict the APN diagnosis and renal scars. MPV is a better predictive factor than CRP, ESR, and WBC values (15). In our study, MPV was lower in the patients with AKI with criteria of loss and failure than in patients with other criteria of AKI.…”

Section: Discussionsupporting

confidence: 38%

Complete Blood Cell and HCO3 as a Predictor of Developing Acute Kidney Injury in Children

et al. 2016

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Background: Acute kidney injury (AKI) due to hypovolemia and gastroenteritis is still a common disease, especially among children in developing countries. The risk, injury, failure, loss, and end-stage renal disease (RIFLE) classification is used as the estimated indicator of outcomes and incidence of AKI. Leukocytosis may be seen with systemic infectious, inflammatory diseases, and pyelonephritis. However, the cell blood count is unspecific. Some studies have shown the role of complete blood count in AKI as a useful predictive factor for mortality. We aimed at investigating cell blood count indexes and HCO3 in the prognosis of children with RIFLE criteria of AKI. Methods: In this prospective study, 206 patients with AKI, who were admitted to Amir-Kabir emergency department, were investigated. The complete blood count, erythrocyte sedimentation rate, serum HCO3, and electrolytes of the patients were measured and compared. All patients were followed monthly for 4 months for renal function test and clinical manifestation. Data analysis was performed by SPSS Version 18 (IBM Corp., NY, US.). Mean, standard deviation, standard error, and frequency were used for descriptive analysis; and t-test, Chi-square, Mann-Whitney and Friedman tests were used for data analysis. Results: There were no significant differences between the 4 groups in white blood cell count, hemoglobin, hematocrit, and ESR at baseline (P > 0.05). The number of platelet units was remarkably higher, but the number of MPV and HCO3 was considerably lower in patients with loss/ failure criteria. Conclusions: MPV is higher in the case of platelets destruction, and this is commonly observed in inflammatory diseases. Metabolic acidosis is related to AKI and may lead to disorders such as hypotension, cardiac dysfunction, and mortality. HCO3, and MPV are likely to act as a predictor of the development of AKI. Conducting a multicenter study with a larger sample size and longer follow-up is suggested to examine the predictive factor of AKI.

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“…MPV and Some Other Infectious Diseases: MPV levels were higher in children with APN than in those with lower urinary tract infection, but its predictive capacity compared with CRP in children with APN is debated [13,15]. MPV levels have been found higher in cirrhotic patients with AFI than in those without bacterial infection or in healthy controls [16,28].…”

Section: Mpv and Brucellosismentioning

confidence: 99%

“…myocardial infarction, ischemic stroke, mesenteric ischemia, deep vein trombosis, decompansated heart failure) or infectious diseases [e.g. sepsis, infective endocarditis, pneumonia, brucellosis, cellulitis, acute pyelonephritis (APN), ascites fluid infection (AFI), hepatitis B or hepatitis C] [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16].…”

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confidence: 99%

Could mean platelet volume be a useful marker for infectious diseases? a review of literature

Afyon¹,

Artuk²

2016

Med-Science

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Mean platelet volume (MPV), a parameter of complete blood count analysis, measures the average size of platelets. The alterations of MPV levels have been described as a diagnostic or prognostic predictor in patients with infectious diseases including sepsis, infective endocarditis, pneumonia, brucellosis, cellulitis, acute pyelonephritis, ascites fluid infection, hepatitis B or hepatitis C in recent studies. Although some matters still remain unclear, it can be said that MPV, especially in a scoring system, may be a cost-effective and useful marker for monitoring and predicting outcomes in patients with some infectious diseases in the future.

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Is the mean platelet volume a predictive marker for the diagnosis of acute pyelonephritis in children?

Abstract: The MPV is a fast and reliable measurement with considerable predictive value for the diagnosis of APN and renal scars, and its predictive capacity is better than that of CRP, ESR, and WBC values.

Cited by 34 publications

References 21 publications

Platelet indices in children with urinary tract infection

Platelet indices in children with urinary tract infection

Complete Blood Cell and HCO3 as a Predictor of Developing Acute Kidney Injury in Children

Could mean platelet volume be a useful marker for infectious diseases? a review of literature

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