Is the Outcome of Pulmonary Resections due to Non-Small Cell Lung Cancer in Octogenarian Patients Worse?

Abstract

Purpose: Lung cancer is one of the major sources of mortality in the elderly. This study was undertaken to assess the early and long-term results of surgical resection in patients older than 70 years of age by comparing the results of patients aged 70–79 years (group 1) with patients older than 80 years of age (group 2). Methods: Data on patient age, gender, spirometry values, side, size, histology and stage of the tumor, surgical procedures, postoperative complications, Charlson comorbidity scores (CCS), and survival were collected. Results: After 1–2 propensity score matching group 1 (70–79 years) included 84 and group 2 (age over 80) 42 cases. The multivariate analysis showed that CCS was the only significant factor affecting the development of complications (p = 0.003). The overall median and 5-year survival of all patients were 55 months and 42.5%, respectively. Although the survival of the elderly group 2 was higher than the first group, the difference did not reach significance (50 vs. 49 months, respectively). Conclusion: The outcomes of surgery in terms of morbidity and mortality rates do not differ between the two age groups. The safety of pulmonary resections in the elderly group is comparable to patients under 70 years if the comorbidities are appropriately controlled. In addition, surgery provides satisfactory survival rates in both age groups.

Peri- and postoperative morbidity and mortality in elderly patients with non-small cell lung cancer: a matched-pair study

“…However, differences in patient populations, particularly with respect to T category, sex and surgical approach, may have biased the conclusions. We demonstrate an association between male sex, loss of FEV (21,27). Others such as Amer et al described a signi cantly higher rate of postoperative arrhythmias and need for intensive care in patients over 80 years of age (12).…”

“…In younger male sex (HR CI Several publications have reported varied 30-day mortality rates following lung resection in patients with NSCLC, ranging from 0-9% (11)(12)(13)(14)(15)(16)(17)(18)(19). The reported 90-day mortality rates ranged from 1.5-10% (5,9,13,(19)(20)(21). These variations in mortality data may be attributed to the heterogeneity of the study populations.…”

Gamma-Glutamyl Transpeptidase to Platelet Ratio Is a Novel and Independent Prognostic Marker for Resectable Lung Cancer: A Propensity Score Matching Study

“…PSM is well known as a validated alternative that matches each subject between study groups with comparable baseline parameters to minimize potential confounding influence within observational investigations. 2,3,5,21) We further matched the propensity score of perioperative clinic-pathologic parameters between the low GPR group and the high GPR group, and then, a total of 84 well-matched pairs were generated for subsequent survival analyses.…”