Is the penetration of clindamycin into the masseter muscle really enough to treat odontogenic infections?

Faggion, Paula I; Isoton, Gabriela; Possa, Eduarda; Tasso, Leandro

doi:10.1007/s00784-020-03656-z

Cited by 1 publication

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“…It is mostly absorbed upon oral administration, with peak concentrations within one hour, and concomitant administration of food does not visibly modify serum concentrations [ 9 ]. It has also been proven that even at doses below the minimal inhibitory concentration (MIC), the use of clindamycin may result in inhibition of the synthesis of bacterial toxins [ 10 ], which is exceptionally significant from a clinical point of view since it limits the adverse effects of bacterial toxins even before the antibiotic impedes the actual proliferation of bacteria. Another study [ 11 ] further demonstrated that clindamycin was able to retard the synthesis of streptolysin S and M, produced by Streptococcus pyogenes , a significant majority of exotoxins produced by Staphylococcus aureus (i.e., alpha-hemolysin or protease), and extracellular lipase produced by Propionibacterium acnes and granulosum .…”

Section: Introductionmentioning

confidence: 99%

Comparative Efficacy of Different Oral Doses of Clindamycin in Preventing Post-Operative Sequelae of Lower Third Molar Surgery—A Randomized, Triple-Blind Study

et al. 2022

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Background and Objectives. Antibiotic regimen optimization is a major concern in post extraction sequelae management following third molar surgery, mostly owing to the absence of universal guidelines. Hence, this study aimed to determine the effect of antibiotic prophylaxis using three different doses of clindamycin on the prevention of infection and other complications following mandibular third molar disimpaction. The secondary outcome was testing whether clindamycin exhibits activity in acute or chronic models of pain using the visual analog scale of pain and the necessity for post-operative rescue analgesia. The tertiary outcome was to assess clindamycin penetration into the saliva by measuring its concentration using liquid chromatography/electrospray ionization tandem mass spectrometry. Materials and Methods. A randomized, two-center, triple-blind, controlled clinical trial was conducted, in which the patients were randomly allocated to three groups: I, receiving 150 mg clindamycin every 8 h; II, receiving 300 mg clindamycin every 8 h; and III, receiving 600 mg clindamycin every 12 h. Each group continued the therapy for five days. Results. An overall decrease in the risk of infection and other post-operative complications, such as trismus, edema, dysphagia, and lymphadenopathy, was achieved, with the best results in group I. Conclusion. As no statistical association was observed between clindamycin concentration in saliva and degree of post-operative inflammation, clindamycin concentration, or pain intensity, smaller doses of clindamycin administered over shorter time periods is recommended.

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Section: Introductionmentioning

confidence: 99%