Is the polycystic ovary syndrome the causative of the increase in inflammatory markers and metabolic risk?

Rey-Roldán, Estela; Lana, Maria Belén Perez; Galluzzo, Liliana; Blanco, G; Onetto, Claudia; Straminsky, Vanesa; Nolting, Manuel

doi:10.3109/09513590.2012.730581

Cited by 12 publications

(10 citation statements)

References 27 publications

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“…Circulating IL-6 was measured in 16 articles, of which five reported significantly higher levels in PCOS women compared to healthy controls (Table 3) [53,55,70,73,116]. The remaining 11 studies found no significant difference in circulating IL-6 between PCOS and non-PCOS women [45,[48][49][50]56,59,63,67,82,92,96].…”

Section: Il-6 Resultsmentioning

confidence: 99%

“…Of these, 45 studies provided data on other inflammatory markers such as IL-6, TNF-α, adiponectin, etc., as summarised in Table 2. Mean ± SD CRP values were not provided in 22 studies [42,46,60,62,63,65,66,68,72,73,78,82,83,92,93,99,108,110,112,118,119,121]. Authors of these articles were contacted to provide the missing data, but no response was received despite several reminders.…”

Section: Included Studiesmentioning

confidence: 99%

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The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Aboeldalyl

James

Seyam

et al. 2021

IJMS

101

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Although the current literature associates polycystic ovarian syndrome (PCOS) with chronic inflammation, the evidence for this link remains inconclusive and its causal nature remains unclear. The purpose of this systematic review was to assess the inflammatory status in PCOS women and to determine whether it is related to PCOS or to its associated adiposity. We searched electronic databases including PUBMED, EMBASE and MEDLINE, SCOPUS, DynaMed plus, TRIP, ScienceDirect and Cochrane Library, for studies investigating C-reactive protein (CRP) and other inflammatory makers in PCOS women versus healthy controls. Quality and risk of bias for selected studies were assessed using the modified Newcastle–Ottawa scale. CRP data were extracted and pooled using RevMan for calculation of the standardized mean difference (SMD) and 95% confidence interval (CI). Eighty-five eligible studies were included in the systematic review, of which 63 were included in the meta-analysis. Pooled analysis of the 63 studies revealed significantly higher circulating CRP in PCOS women (n = 4086) versus controls (n = 3120) (SMD 1.26, 95%CI, 0.99, 1.53). Sensitivity meta-analysis of 35 high quality studies including non-obese women showed significantly higher circulating CRP in PCOS women versus controls (SMD 1.80, 95%CI, 1.36, 2.25). In conclusion, circulating CRP is moderately elevated in PCOS women independent of obesity, which is indicative of low-grade chronic inflammation.

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Section: Il-6 Resultsmentioning

confidence: 99%

Section: Included Studiesmentioning

confidence: 99%

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Aboeldalyl

James

Seyam

et al. 2021

IJMS

101

View full text Add to dashboard Cite

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“…Due to the nature of the study, this could have encouraged some students experiencing PCOS-like symptoms to come forward for this study, while others without PCOS were not involved in PCOS screening, which could have had an impact on the results of this present study. On the contrary, previous studies have often used hospital settings such as blood donation centers19 and in vitro fertilization (IVF) clinic patients,20 who might be considered as biased samples. Females who donate blood are generally healthy, which could account for the low frequency of PCOS in those study groups.…”

Section: Discussionmentioning

confidence: 99%

The frequency of polycystic ovary syndrome in young reproductive females in Qatar

Sharif

Rahman

Zia

et al. 2016

IJWH

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This was a prospective cross-sectional study in which 126 female students between the ages of 18 and 30 years were evaluated for the frequency of polycystic ovary syndrome (PCOS) through clinical interview, questionnaire, and anthropometric measurements. The diagnostic criteria of the US National Institutes of Health criteria were used. Menstrual irregularities (MI) were identified, and clinical hyperandrogenism was evaluated by self-assessment of hirsutism using modified Ferriman–Gallwey score. Blood analysis was done for measurement of prolactin, thyroid-stimulating hormone, and the androgen hormones. Of all the students, 37 (30.8%) had MI, 38 (31.7%) had clinical hirsutism, 37 (30.8%) had acne, and 76 (63.3%) had a family history of type 2 diabetes. The estimated frequency of PCOS was 18.33% according to the US National Institutes of Health definition. Hormonal analysis demonstrated a significant increase in androgens (total testosterone, dehydroepiandrosterone sulfate, and free testosterone), and a significant decrease in sex hormone-binding globulin in our PCOS group, with a P-value <0.05. This study revealed a higher level of the androgen hormones among PCOS subjects with a frequency of PCOS (18.33%) similar to the global estimates of 10%–20%.

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“…Data concerning C-reactive protein (CRP), a classic inflammation marker, are controversial. Several studies showed higher CRP concentrations in PCOS women than in controls 12,13 , while other authors report no significant differences when comparing both groups of women 14,15 .…”

Section: Introductionmentioning

confidence: 92%

Association Between Vitamin D and Adrenal Parameters with Metabolic and Inflammatory Markers in Polycystic Ovary Syndrome

Maidana

Fritzler

Mocarbel

et al. 2019

Sci Rep

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Vitamin D deficiency has been related with metabolic alterations in polycystic ovary syndrome (PCOS). As well, hyperactivation of adrenal axis can be programmed early in life and could be related later with PCOS development. Our aim was to establish the relationship between vitamin D and adrenal parameters with metabolic alterations and inflammation markers in PCOS. In 73 patients and 33 controls, 25-hydroxyvitamin D (25-OH-D), total and bioavailable testosterone (TT and bioT), androstenedione (A4), SHBG, cortisol, insulin, and C-reactive protein (hs-CRP) were determined; HOMA and lipid accumulation product (LAP) index were calculated. All parameters were higher in patients than in controls, except for SHBG and 25-OH-D which were lower. Binary regression analysis showed that differences in TT, bioT, A4, insulin and HOMA were independent of body mass index and waist circumference but SHBG, hs-CRP, LAP and 25-OH-D were related to body weight and fat distribution. Binary logistic regression analysis showed that cortisol and 25-OH-D could be associated to PCOS development. Correlations found between LAP and insulin, HOMA and hs-CRP confirm it is a good indicator of metabolic complications. Vitamin D and cortisol association to PCOS development justifies future research to understand the role of vitamin D in PCOS and analyze patient’s perinatal history and its possible relationship with hyperactivation of adrenal axis in adult life.

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Is the polycystic ovary syndrome the causative of the increase in inflammatory markers and metabolic risk?

Abstract: The present study demonstrates the presence of a chronic inflammation status in young women with PCO. These parameters are mainly related to obesity and, to a lesser extent, to IR.

Cited by 12 publications

References 27 publications

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

The frequency of polycystic ovary syndrome in young reproductive females in Qatar

Association Between Vitamin D and Adrenal Parameters with Metabolic and Inflammatory Markers in Polycystic Ovary Syndrome

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