1979
DOI: 10.1073/pnas.76.1.348
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Is the product of the src gene a promoter?

Abstract: Addition of a potent promotor, 12-O-tetradecanoylphorbol 13-acetate (TPA), to primary avian tendon or chicken embryo fibroblast cells infected with a temperaturesensitive mutant of Rous sarcoma virus produced a complete transformed phenocopy at the non rmissive temperature by the criteria tested. While normal, uninfected cultures also shifted towards a transformed phenotype after TPA addition, they did not achieve the same degree of morphological and biochemical alteration seen in virus-infected, TPAtreated ce… Show more

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Cited by 42 publications
(14 citation statements)
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“…These TPA-induced alterations were enhanced in ts-RSV-infected cells kept at nonpermissive temperatures as reported (16) and were found to be sensitive to cycloheximide in both types of cells (Fig. 3).…”
Section: Resultssupporting
confidence: 56%
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“…These TPA-induced alterations were enhanced in ts-RSV-infected cells kept at nonpermissive temperatures as reported (16) and were found to be sensitive to cycloheximide in both types of cells (Fig. 3).…”
Section: Resultssupporting
confidence: 56%
“…However, in vitro assays do not always reflect the state of enzymatic activity in the intact cell (27). The (5), and that increased levels of phosphotyrosine are not found in all virally or chemically transformed cells (27) (16).…”
Section: Discussionmentioning
confidence: 99%
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“…Tumor promoters induce many of the changes which accompany malignant transformation (5,6,23,47,64). The phorbol ester TPA is mitogenic for several types of cells in culture (21,22,54).…”
Section: Resultsmentioning
confidence: 99%
“…Wounding is also a tumor promoter because it can cause cancer to develop at the edges of wounds inflicted in areas that have been exposed previously to a carcinogen (10 -15). The v-src oncogene, which is the transforming protein of the Rous sarcoma virus (a retrovirus that causes tumors in chickens), also has been shown to be a tumor promoter (16). The 9E3 gene and its product, the chicken chemotactic and angiogenic factor (cCAF), 1 are stimulated to high levels by the v-src oncogene and also by phorbol esters and wounding/inflammation (17)(18)(19)(20)(21).…”
mentioning
confidence: 99%