Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis?

S, Sunitha; Rajappa, Medha; Thappa, Devinder Mohan; Chandrashekar, Laxmisha; Munisamy, Malathi; Revathy, G.

doi:10.5001/omj.2016.78

Cited by 11 publications

(13 citation statements)

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“…Among 45 patients with moderate psoriasis severity (mean PASI: 14.0 ±8.3), Sunitha et al found a correlation between the PASI and anti-oxLDL and oxLDL concentrations. Moreover, compared to controls, patients with psoriasis had a higher anti-ox-LDL : oxLDL ratio, which indicated greater oxidative stress [ 32 ]. Patients with psoriasis were found to have oxLDLs in the epidermis and serum [ 5 , 8 , 11 , 24 , 25 , 32 ], as well as antibodies against HDLs or apolipoprotein AI [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

Pietrzak

Chabros

Grywalska

et al. 2019

aoms

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IntroductionPsoriasis and psoriatic arthritis (PSA) are chronic, inflammatory, systemic diseases characterized by metabolic abnormalities, including an increased cardiovascular risk and an oxidative imbalance. This study assessed blood parameters of lipid metabolism and markers of oxidative stress in patients with psoriasis and PSA.Material and methodsThe study included 93 patients with psoriasis (31 patients with PSA and psoriasis, 62 patients with psoriasis vulgaris), and 60 healthy, age-matched controls. Serum concentrations of the glucose and the following lipid metabolism parameters were measured: triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), high-density lipoproteins (HDL), and apolipoproteins A and B (ApoA, ApoB). Oxidative status was determined as serum concentrations of ox-LDL/MDA Adduct. The Psoriasis Area and Severity Index (PASI) was used to determine disease severity.ResultsAmong the three studied groups, controls had the highest HDL concentration (p < 0.001), patients with PSA had the highest ApoB concentration (p < 0.05), ApoA : ApoB ratio (p < 0.05), ox-LDL/MDA adduct concentration (p < 0.001), and TC: HDL and LDL : HDL ratios (accordingly p < 0.05, p < 0.01). In patients with psoriasis or PSA, oxidative status correlated positively with TC and ApoB concentrations.ConclusionsIn line with previous research, among patients with psoriasis and PSA, we found lipid metabolism abnormalities and an oxidative imbalance, which might be due to chronic inflammation in these conditions. Effective treatment of patients with psoriasis or PSA could reduce the risk of cardiovascular diseases.

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Section: Discussionmentioning

confidence: 99%

Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

Pietrzak

Chabros

Grywalska

et al. 2019

aoms

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“…It showed that the anti-ox-LDL/ox-LDL ratio correlated significantly with disease severity, its levels increasing linearly with increasing severity. 35 Nakhwa et al did not find a statistically significant correlation between PASI score determined severity of disease and lipid profile abnormalities. At the same time, they found a reduced HDL-C level in patients with severe form of psoriasis.…”

Section: Discussionmentioning

confidence: 92%

The role of high-dose vitamin D supplementation on disease severity and lipid profile in psoriatic patients: A pilot study

Prtina¹,

Grabež²,

Vujnic³

et al. 2020

Scripta Medica

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Background/Aim: Psoriasis is a chronic inflammatory skin disease that is associated with a higher prevalence of cardiovascular (CV) risk factors. The effect of vitamin D on bone health has been long known, but its extraskeletal role especially in cardiovascular disease and skin disease, is the subject of recent research. This study aimed to assess the influence of high-dose vitamin D supplementation on the Psoriasis Area and Severity Index (PASI) score and lipid profile in patients with psoriasis. Methods: The study included 20 adult patients with chronic plaque psoriasis. They received vitamin D capsules in a daily dose of 5,000 IU over 12 weeks. Measured serum concentrations of lipid metabolism parameters were triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL) and high-density lipoproteins (HDL). PASI was used to determine the severity of the disease. Results: High-doses vitamin D supplementation had a significant influence on reduction in PASI score in all patients (17.99 ± 12.42 vs 10.27 ± 8.53; p < 0.001). The supplementation of high dose vitamin D induced statistically significant lowering of the TC, LDL-C and TG in the psoriatic patients (p < 0.05). Furthermore, significant increase in serum HDL-C level was observed. The change of PASI score showed week positive correlation with the changes in serum TC and LDL-C (r = 0.303, p = 0.03 and r = 0.357 p = 0.013). Conclusion: High-dose vitamin D supplementation had a positive impact on clinical status of the chronic plaque psoriasis patients, measured by PASI score. It also improved the serum lipid profile of these patients. Double-blinded prospective studies are needed in order to get more comprehensive data related to vitamin D, lipid metabolism and severity of psoriasis.

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“…Chronic inflammation in psoriatic lesions affects the formation of reactive oxygen species (ROS) leading to 'oxidative stress.' 45 They cause damage to endothelial cells, increase permeability of small blood and allow the migration of inflammatory cells. Oxidative stress increases the production of eicosanoids (by activation of phospholipase A) which have proinflammatory and chemoattractant properties.…”

Section: Cyclitols and Oxidative Stressmentioning

confidence: 99%